ID   TX5A_DINQU              Reviewed;          53 AA.
AC   P0DSL6;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   08-MAY-2019, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=U1-poneritoxin-Dq5a {ECO:0000303|PubMed:26805882};
DE            Short=U1-PONTX-Dq5a {ECO:0000303|PubMed:26805882};
DE   AltName: Full=Dinoponera ICK-like toxin {ECO:0000303|PubMed:24498135};
DE   AltName: Full=Poneratoxin {ECO:0000305};
DE   Flags: Precursor;
OS   Dinoponera quadriceps (South American ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Ponerinae; Ponerini; Dinoponera.
OX   NCBI_TaxID=609295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=24498135; DOI=10.1371/journal.pone.0087556;
RA   Torres A.F., Huang C., Chong C.M., Leung S.W., Prieto-da-Silva A.R.,
RA   Havt A., Quinet Y.P., Martins A.M., Lee S.M., Radis-Baptista G.;
RT   "Transcriptome analysis in venom gland of the predatory giant ant
RT   Dinoponera quadriceps: insights into the polypeptide toxin arsenal of
RT   hymenopterans.";
RL   PLoS ONE 9:E87556-E87556(2014).
RN   [2]
RP   REVIEW, AND NOMENCLATURE.
RX   PubMed=26805882; DOI=10.3390/toxins8010030;
RA   Touchard A., Aili S.R., Fox E.G., Escoubas P., Orivel J., Nicholson G.M.,
RA   Dejean A.;
RT   "The biochemical toxin arsenal from ant venoms.";
RL   Toxins 8:1-28(2016).
CC   -!- FUNCTION: May have neurotoxic activity. {ECO:0000250|UniProtKB:Q26443}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:24498135}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:24498135}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin.
CC       {ECO:0000250|UniProtKB:P0C201}.
CC   -!- WEB RESOURCE: Name=National Center for Biotechnology Information
CC       (NCBI);
CC       URL="https://www.ncbi.nlm.nih.gov/nuccore/GANS01000017";
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DR   AlphaFoldDB; P0DSL6; -.
DR   SMR; P0DSL6; -.
DR   Proteomes; UP000515204; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Disulfide bond; Knottin; Neurotoxin; Reference proteome; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         24..53
FT                   /note="U1-poneritoxin-Dq5a"
FT                   /evidence="ECO:0000305|PubMed:24498135"
FT                   /id="PRO_0000447111"
FT   DISULFID        25..42
FT                   /evidence="ECO:0000250|UniProtKB:P0C201,
FT                   ECO:0000250|UniProtKB:Q26443"
FT   DISULFID        32..47
FT                   /evidence="ECO:0000250|UniProtKB:P0C201,
FT                   ECO:0000250|UniProtKB:Q26443"
FT   DISULFID        41..52
FT                   /evidence="ECO:0000250|UniProtKB:P0C201,
FT                   ECO:0000250|UniProtKB:Q26443"
SQ   SEQUENCE   53 AA;  5835 MW;  F03A276E0126FF66 CRC64;
     MNIRLMFTLI ALLVLTVSFS GANSCFKRNR QCKGSFLKSA CCEGLKCVNG RCT
//