ID APOC1_URSMA Reviewed; 88 AA. AC P0DPH6; DT 20-JUN-2018, integrated into UniProtKB/Swiss-Prot. DT 20-JUN-2018, sequence version 1. DT 08-MAY-2019, entry version 9. DE RecName: Full=Apolipoprotein C-I; DE Short=Apo-CI; DE Short=ApoC-I; DE AltName: Full=Apolipoprotein C1; DE Contains: DE RecName: Full=Truncated apolipoprotein C-I; DE Flags: Precursor; GN Name=APOC1; OS Ursus maritimus (Polar bear) (Thalarctos maritimus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; OC Ursus. OX NCBI_TaxID=29073; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=24813606; DOI=10.1016/j.cell.2014.03.054; RA Liu S., Lorenzen E.D., Fumagalli M., Li B., Harris K., Xiong Z., RA Zhou L., Korneliussen T.S., Somel M., Babbitt C., Wray G., Li J., RA He W., Wang Z., Fu W., Xiang X., Morgan C.C., Doherty A., RA O'Connell M.J., McInerney J.O., Born E.W., Dalen L., Dietz R., RA Orlando L., Sonne C., Zhang G., Nielsen R., Willerslev E., Wang J.; RT "Population genomics reveal recent speciation and rapid evolutionary RT adaptation in polar bears."; RL Cell 157:785-794(2014). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Malenfant R.M., Coltman D.W., Richardson E.S., Lunn N.J., RA Andriashek D.S., Davis C.S.; RT "Transcriptome assembly and SNP discovery in polar bears (Ursus RT maritimus) of Western Hudson Bay."; RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases. RN [3] RP IDENTIFICATION. RA Puppione D.L.; RL Unpublished observations (MAY-2018). CC -!- FUNCTION: Inhibitor of lipoprotein binding to the low density CC lipoprotein (LDL) receptor, LDL receptor-related protein, and very CC low density lipoprotein (VLDL) receptor. Associates with high CC density lipoproteins (HDL) and the triacylglycerol-rich CC lipoproteins in the plasma and makes up about 10% of the protein CC of the VLDL and 2% of that of HDL. Appears to interfere directly CC with fatty acid uptake and is also the major plasma inhibitor of CC cholesteryl ester transfer protein (CETP). Binds free fatty acids CC and reduces their intracellular esterification. Modulates the CC interaction of APOE with beta-migrating VLDL and inhibits binding CC of beta-VLDL to the LDL receptor-related protein. CC {ECO:0000250|UniProtKB:P02654, ECO:0000250|UniProtKB:P33047}. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- SIMILARITY: Belongs to the apolipoprotein C1 family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AVOR01000000; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; GAJD01000000; -; NOT_ANNOTATED_CDS; Transcribed_RNA. DR RefSeq; XP_008682671.1; XM_008684449.1. DR Ensembl; ENSUMAT00000038279; ENSUMAP00000032380; ENSUMAG00000023318. DR GeneID; 103657040; -. DR KEGG; umr:103657040; -. DR CTD; 341; -. DR GeneTree; ENSGT00390000011584; -. DR KO; K22286; -. DR Proteomes; UP000261680; Genome assembly. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:Ensembl. DR GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW. DR GO; GO:0005504; F:fatty acid binding; IEA:Ensembl. DR GO; GO:0004859; F:phospholipase inhibitor activity; IEA:Ensembl. DR GO; GO:0033344; P:cholesterol efflux; IEA:Ensembl. DR GO; GO:0008203; P:cholesterol metabolic process; IEA:Ensembl. DR GO; GO:0034382; P:chylomicron remnant clearance; IEA:Ensembl. DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro. DR GO; GO:0032375; P:negative regulation of cholesterol transport; IEA:Ensembl. DR GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:Ensembl. DR GO; GO:0051005; P:negative regulation of lipoprotein lipase activity; IEA:Ensembl. DR GO; GO:0010900; P:negative regulation of phosphatidylcholine catabolic process; IEA:Ensembl. DR GO; GO:0048261; P:negative regulation of receptor-mediated endocytosis; IEA:Ensembl. DR GO; GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IEA:Ensembl. DR GO; GO:0033700; P:phospholipid efflux; IEA:Ensembl. DR GO; GO:0034369; P:plasma lipoprotein particle remodeling; IEA:Ensembl. DR GO; GO:0006641; P:triglyceride metabolic process; IEA:Ensembl. DR GO; GO:0034447; P:very-low-density lipoprotein particle clearance; IEA:Ensembl. DR InterPro; IPR006781; ApoC-I. DR PANTHER; PTHR16565; PTHR16565; 1. DR Pfam; PF04691; ApoC-I; 1. PE 3: Inferred from homology; KW Complete proteome; Lipid transport; Reference proteome; Secreted; KW Signal; Transport; VLDL. FT SIGNAL 1 26 {ECO:0000255}. FT CHAIN 27 88 Apolipoprotein C-I. FT /FTId=PRO_0000444596. FT CHAIN 29 88 Truncated apolipoprotein C-I. FT {ECO:0000250|UniProtKB:P86336}. FT /FTId=PRO_0000444597. SQ SEQUENCE 88 AA; 9676 MW; 9BED258A50CE3A0B CRC64; MRLFLSLPVW VAVLAMVLEG PAPAQAAPEI SSTLGSIPDK LKEFGNTLED KARAAIESIK QSDIPAKTRN WFSETFNKVK EQLKTAFS //