ID APOC1_URSMA Reviewed; 88 AA. AC P0DPH6; DT 20-JUN-2018, integrated into UniProtKB/Swiss-Prot. DT 20-JUN-2018, sequence version 1. DT 10-FEB-2021, entry version 15. DE RecName: Full=Apolipoprotein C-I; DE Short=Apo-CI; DE Short=ApoC-I; DE AltName: Full=Apolipoprotein C1; DE Contains: DE RecName: Full=Truncated apolipoprotein C-I; DE Flags: Precursor; GN Name=APOC1; OS Ursus maritimus (Polar bear) (Thalarctos maritimus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus. OX NCBI_TaxID=29073; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=24813606; DOI=10.1016/j.cell.2014.03.054; RA Liu S., Lorenzen E.D., Fumagalli M., Li B., Harris K., Xiong Z., Zhou L., RA Korneliussen T.S., Somel M., Babbitt C., Wray G., Li J., He W., Wang Z., RA Fu W., Xiang X., Morgan C.C., Doherty A., O'Connell M.J., McInerney J.O., RA Born E.W., Dalen L., Dietz R., Orlando L., Sonne C., Zhang G., Nielsen R., RA Willerslev E., Wang J.; RT "Population genomics reveal recent speciation and rapid evolutionary RT adaptation in polar bears."; RL Cell 157:785-794(2014). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Malenfant R.M., Coltman D.W., Richardson E.S., Lunn N.J., Andriashek D.S., RA Davis C.S.; RT "Transcriptome assembly and SNP discovery in polar bears (Ursus maritimus) RT of Western Hudson Bay."; RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases. RN [3] RP IDENTIFICATION. RA Puppione D.L.; RL Unpublished observations (MAY-2018). CC -!- FUNCTION: Inhibitor of lipoprotein binding to the low density CC lipoprotein (LDL) receptor, LDL receptor-related protein, and very low CC density lipoprotein (VLDL) receptor. Associates with high density CC lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the CC plasma and makes up about 10% of the protein of the VLDL and 2% of that CC of HDL. Appears to interfere directly with fatty acid uptake and is CC also the major plasma inhibitor of cholesteryl ester transfer protein CC (CETP). Binds free fatty acids and reduces their intracellular CC esterification. Modulates the interaction of APOE with beta-migrating CC VLDL and inhibits binding of beta-VLDL to the LDL receptor-related CC protein. {ECO:0000250|UniProtKB:P02654, ECO:0000250|UniProtKB:P33047}. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- SIMILARITY: Belongs to the apolipoprotein C1 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AVOR01000000; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; GAJD01000000; -; NOT_ANNOTATED_CDS; Transcribed_RNA. DR RefSeq; XP_008682671.1; XM_008684449.1. DR SMR; P0DPH6; -. DR Ensembl; ENSUMAT00000038279; ENSUMAP00000032380; ENSUMAG00000023318. DR GeneID; 103657040; -. DR KEGG; umr:103657040; -. DR CTD; 341; -. DR GeneTree; ENSGT00390000011584; -. DR OMA; RSWFSET; -. DR Proteomes; UP000261680; Genome assembly. DR Proteomes; UP000291021; Unassembled WGS sequence. DR GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW. DR GO; GO:0008203; P:cholesterol metabolic process; IEA:Ensembl. DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW. DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro. DR GO; GO:0006641; P:triglyceride metabolic process; IEA:Ensembl. DR Gene3D; 4.10.260.30; -; 1. DR InterPro; IPR043081; ApoC-1_sf. DR InterPro; IPR006781; ApoC-I. DR PANTHER; PTHR16565; PTHR16565; 1. DR Pfam; PF04691; ApoC-I; 1. PE 3: Inferred from homology; KW Lipid transport; Reference proteome; Secreted; Signal; Transport; VLDL. FT SIGNAL 1..26 FT /evidence="ECO:0000255" FT CHAIN 27..88 FT /note="Apolipoprotein C-I" FT /id="PRO_0000444596" FT CHAIN 29..88 FT /note="Truncated apolipoprotein C-I" FT /evidence="ECO:0000250|UniProtKB:P86336" FT /id="PRO_0000444597" SQ SEQUENCE 88 AA; 9676 MW; 9BED258A50CE3A0B CRC64; MRLFLSLPVW VAVLAMVLEG PAPAQAAPEI SSTLGSIPDK LKEFGNTLED KARAAIESIK QSDIPAKTRN WFSETFNKVK EQLKTAFS //