ID NDB5A_CHATY Reviewed; 91 AA. AC P0DMF1; DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot. DT 16-APR-2014, sequence version 1. DT 01-OCT-2014, entry version 4. DE RecName: Full=Peptide Ctry2146; DE AltName: Full=Non-disulfide-bridged peptide 5; DE Short=NDBP-5; DE Flags: Precursor; OS Chaerilus tryznai (Scorpion). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; OC Scorpiones; Chaerilida; Chaeriloidea; Chaerilidae; Chaerilus. OX NCBI_TaxID=1464547; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND SYNTHESIS OF 24-33. RC TISSUE=Venom gland; RX PubMed=23415044; DOI=10.1016/j.biomaterials.2013.01.075; RA Hong W., Zhang R., Di Z., He Y., Zhao Z., Hu J., Wu Y., Li W., Cao Z.; RT "Design of histidine-rich peptides with enhanced bioavailability and RT inhibitory activity against hepatitis C virus."; RL Biomaterials 34:3511-3522(2013). CC -!- FUNCTION: Antimicrobial peptide. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Target cell membrane CC {ECO:0000250}. Note=Forms an alpha-helical membrane channel in the CC prey. {ECO:0000250}. CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. CC -!- MISCELLANEOUS: Shows a low ability to inhibit hepatitis C virus CC (HCV) infection in Huh7.5.1 cells. {ECO:0000305|PubMed:23415044}. CC -!- SIMILARITY: Belongs to the scorpion NDBP 5 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0050688; P:regulation of defense response to virus; IEA:UniProtKB-KW. PE 2: Evidence at transcript level; KW Amidation; Antimicrobial; Antiviral protein; Membrane; Secreted; KW Signal; Target cell membrane; Target membrane. FT SIGNAL 1 23 {ECO:0000255}. FT PEPTIDE 24 33 Peptide Ctry2146. FT /FTId=PRO_0000428693. FT PROPEP 37 91 {ECO:0000250}. FT /FTId=PRO_0000428694. FT MOD_RES 33 33 Leucine amide. {ECO:0000250}. SQ SEQUENCE 91 AA; 9953 MW; B13564795B0E0778 CRC64; MKTQTLLVTF LVVLLMVATQ TEAGIADILK GLLGKRGLLD GLLGKRGLLF GKRGPLFGKR ALTNQDFLDF AYDPSLSAAD MDALEMLFED Y //