ID APOC1_ATEGE Reviewed; 86 AA. AC P0DKV3; DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot. DT 06-FEB-2013, sequence version 1. DT 18-SEP-2013, entry version 5. DE RecName: Full=Apolipoprotein C-I; DE AltName: Full=Apolipoprotein C1; DE Contains: DE RecName: Full=Truncated apolipoprotein C-I; DE Flags: Precursor; GN Name=APOC1; OS Ateles geoffroyi (Black-handed spider monkey) (Geoffroy's spider OS monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Atelidae; Atelinae; Ateles. OX NCBI_TaxID=9509; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Cheng J.-F., Hamilton M., Peng Y., Hosseini R., Peng Z., Malinov I., RA Rubin E.M.; RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases. RN [2] RP IDENTIFICATION. RA Puppione D.L.; RL Unpublished observations (NOV-2012). CC -!- FUNCTION: Appears to modulate the interaction of APOE with beta- CC migrating VLDL and inhibit binding of beta-VLDL to the LDL CC receptor-related protein. Binds free fatty acids and reduces their CC intracellular esterification (By similarity). CC -!- SUBCELLULAR LOCATION: Secreted (By similarity). CC -!- MISCELLANEOUS: Apolipoprotein C-I is present in acidic (APOC1A) CC and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes CC and perhaps also in baboons and macaques. In human, the acidic CC form has become a pseudogene. CC -!- SIMILARITY: Belongs to the apolipoprotein C1 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC188244; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW. DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW. DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro. DR Gene3D; 4.10.260.30; -; 1. DR InterPro; IPR006781; ApoC-I. DR PANTHER; PTHR16565; PTHR16565; 1. DR Pfam; PF04691; ApoC-I; 1. PE 3: Inferred from homology; KW Lipid transport; Secreted; Signal; Transport; VLDL. FT SIGNAL 1 26 By similarity. FT CHAIN 27 86 Apolipoprotein C-I. FT /FTId=PRO_0000420976. FT CHAIN 29 86 Truncated apolipoprotein C-I (By FT similarity). FT /FTId=PRO_0000420977. SQ SEQUENCE 86 AA; 9716 MW; 0B7E4CAB7A4DFB08 CRC64; MRLFLSLPVL VVVLLMILEG PGPAQGAPEA LDTSSGLDKL KEFGNTLEDK VREFFNRVKE SDIPAKTRNW FSETLQKVKE KLRIES //