ID KKX32_HETPE Reviewed; 62 AA. AC P0DJ37; DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot. DT 18-APR-2012, sequence version 1. DT 06-MAR-2013, entry version 5. DE RecName: Full=Potassium channel toxin kappa-KTx 3.2; DE AltName: Full=HSP040C.3; DE Flags: Precursor; OS Heterometrus petersii (Asian forest scorpion). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; OC Scorpiones; Iurida; Scorpionoidea; Scorpionidae; Scorpioninae; OC Heterometrus. OX NCBI_TaxID=754296; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND IDENTIFICATION BY MASS SPECTROMETRY. RC TISSUE=Venom, and Venom gland; RX PubMed=20443192; DOI=10.1002/pmic.200900763; RA Ma Y., Zhao Y., Zhao R., Zhang W., He Y., Wu Y., Cao Z., Guo L., RA Li W.; RT "Molecular diversity of toxic components from the scorpion RT Heterometrus petersii venom revealed by proteomic and transcriptome RT analysis."; RL Proteomics 10:2471-2485(2010). RN [2] RP NOMENCLATURE. RX PubMed=22305749; DOI=10.1016/j.bcp.2012.01.021; RA Vandendriessche T., Kopljar I., Jenkins D.P., Diego-Garcia E., RA Abdel-Mottaleb Y., Vermassen E., Clynen E., Schoofs L., Wulff H., RA Snyders D., Tytgat J.; RT "Purification, molecular cloning and functional characterization of RT HelaTx1 (Heterometrus laoticus): the first member of a new kappa-KTX RT subfamily."; RL Biochem. Pharmacol. 83:1307-1317(2012). CC -!- FUNCTION: Potassium channel inhibitor (Kv) (By similarity). CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. CC -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. CC Potassium channel inhibitor kappa-KTx family. Kappa-KTx 3 CC subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0019870; F:potassium channel inhibitor activity; IEA:UniProtKB-KW. PE 1: Evidence at protein level; KW Disulfide bond; Ion channel impairing toxin; Neurotoxin; KW Potassium channel inhibitor; Secreted; Signal; Toxin. FT SIGNAL 1 26 Potential. FT PROPEP 27 36 By similarity. FT /FTId=PRO_0000416804. FT PEPTIDE 38 62 Potassium channel toxin kappa-KTx 3.2. FT /FTId=PRO_0000416805. FT DISULFID 43 61 By similarity. FT DISULFID 47 57 By similarity. SQ SEQUENCE 62 AA; 7029 MW; EEC3DBCD004A5519 CRC64; MKSTLMTASL LILVLLSIVD YASVYAELID SEISMERHWI NACFNICMKI SSDQKYCKSF CG //