ID TOR2X_MOUSE Reviewed; 231 AA. AC P0C7W3; DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot. DT 22-JUL-2008, sequence version 1. DT 15-MAR-2017, entry version 56. DE RecName: Full=Prosalusin; DE AltName: Full=Torsin family 2 member A; DE AltName: Full=Torsin-2A; DE Contains: DE RecName: Full=Salusin-beta; DE Flags: Precursor; GN Name=Tor2a; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] RP REGION. RX PubMed=16697365; DOI=10.1016/j.ejphar.2006.03.064; RA Wang Z., Takahashi T., Saito Y., Nagasaki H., Ly N.K., RA Nothacker H.-P., Reinscheid R.K., Yang J., Chang J.K., Shichiri M., RA Civelli O.; RT "Salusin beta is a surrogate ligand of the mas-like G protein-coupled RT receptor MrgA1."; RL Eur. J. Pharmacol. 539:145-150(2006). CC -!- FUNCTION: Salusin may be a endocrine and/or paracrine factor able CC to increase intracellular calcium concentrations and induce cell CC mitogenesis. Salusin may also be a potent hypotensive peptide (By CC similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=3; CC IsoId=P0C7W3-1; Sequence=Displayed; CC Note=Salusin-beta peptide is derived from isoform 3.; CC Name=1; CC IsoId=Q8R1J9-1; Sequence=External; CC Name=2; CC IsoId=Q8R1J9-2; Sequence=External; CC Note=No experimental confirmation available.; CC -!- SIMILARITY: Belongs to the ClpA/ClpB family. Torsin subfamily. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL772271; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR UniGene; Mm.200695; -. DR ProteinModelPortal; P0C7W3; -. DR SMR; P0C7W3; -. DR STRING; 10090.ENSMUSP00000009707; -. DR PaxDb; P0C7W3; -. DR PeptideAtlas; P0C7W3; -. DR PRIDE; P0C7W3; -. DR MGI; MGI:1353596; Tor2a. DR eggNOG; KOG2170; Eukaryota. DR eggNOG; ENOG410XR06; LUCA. DR HOVERGEN; HBG094082; -. DR ChiTaRS; Tor2a; mouse. DR Proteomes; UP000000589; Unplaced. DR CleanEx; MM_TOR2A; -. DR GO; GO:0005788; C:endoplasmic reticulum lumen; IDA:MGI. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0051260; P:protein homooligomerization; IDA:MGI. DR Gene3D; 3.40.50.300; -; 1. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR010448; Torsin. DR PANTHER; PTHR10760; PTHR10760; 1. DR Pfam; PF06309; Torsin; 1. DR SUPFAM; SSF52540; SSF52540; 1. PE 3: Inferred from homology; KW Alternative splicing; ATP-binding; Cleavage on pair of basic residues; KW Complete proteome; Glycoprotein; Hormone; Nucleotide-binding; KW Reference proteome; Secreted; Signal. FT SIGNAL 1 27 {ECO:0000255}. FT CHAIN 28 231 Prosalusin. FT /FTId=PRO_0000345614. FT PROPEP 28 189 {ECO:0000255}. FT /FTId=PRO_0000345615. FT PEPTIDE 192 231 Salusin-beta. {ECO:0000250}. FT /FTId=PRO_0000345616. FT NP_BIND 93 100 ATP. {ECO:0000255}. FT REGION 192 211 Partial activation of MRGPRA1. FT CARBOHYD 149 149 N-linked (GlcNAc...). {ECO:0000255}. SQ SEQUENCE 231 AA; 25377 MW; 56DC8F6C09F5EFC5 CRC64; MAVARHGYRP WGSILGLLGL ALAAAAAWDV ASLRCTFGSF CECDFWPDLP GLECDLAQHL AGQHLAKALV VKSLKAFVQD PAPSKPLVLS LHGWTGTGKS YVSSLLAQHL FRDGLRSPHV HHFSPIIHFP HPSRTEQYKK ELKSWVQGNL TACGRSLFLF DEMDKLPPGL MEVLQPFLGP SWVVYGTNYR KAIFIFIRWL LAVWHHGGAP AGRCGALPPA PAASRAPLRT Q //