ID TOR2X_MOUSE Reviewed; 231 AA. AC P0C7W3; DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot. DT 22-JUL-2008, sequence version 1. DT 04-NOV-2008, entry version 3. DE RecName: Full=Prosalusin; DE AltName: Full=Torsin-2A; DE AltName: Full=Torsin family 2 member A; DE Contains: DE RecName: Full=Salusin-beta; DE Flags: Precursor; GN Name=Tor2a; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J; RG The mouse genome sequencing consortium; RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases. RN [2] RP REGION. RX PubMed=16697365; DOI=10.1016/j.ejphar.2006.03.064; RA Wang Z., Takahashi T., Saito Y., Nagasaki H., Ly N.K., RA Nothacker H.-P., Reinscheid R.K., Yang J., Chang J.K., Shichiri M., RA Civelli O.; RT "Salusin beta is a surrogate ligand of the mas-like G protein-coupled RT receptor MrgA1."; RL Eur. J. Pharmacol. 539:145-150(2006). CC -!- FUNCTION: Salusin may be a endocrine and/or paracrine factor able CC to increase intracellular calcium concentrations and induce cell CC mitogenesis. Salusin may also be a potent hypotensive peptide (By CC similarity). CC -!- SUBCELLULAR LOCATION: Secreted (By similarity). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=3; CC IsoId=P0C7W3-1; Sequence=Displayed; CC Note=Salusin-beta peptide is derived from isoform 3; CC Name=1; CC IsoId=Q8R1J9-1; Sequence=External; CC Name=2; CC IsoId=Q8R1J9-2; Sequence=External; CC -!- SIMILARITY: Belongs to the clpA/clpB family. Torsin subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL772271; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR MGI; MGI:1353596; Tor2a. DR CleanEx; MM_TOR2A; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW. DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW. PE 2: Evidence at transcript level; KW Alternative splicing; ATP-binding; Cleavage on pair of basic residues; KW Glycoprotein; Hormone; Nucleotide-binding; Secreted; Signal. FT SIGNAL 1 27 Potential. FT CHAIN 28 231 Prosalusin. FT /FTId=PRO_0000345614. FT PROPEP 28 189 Potential. FT /FTId=PRO_0000345615. FT PEPTIDE 192 231 Salusin-beta (By similarity). FT /FTId=PRO_0000345616. FT NP_BIND 93 100 ATP (Potential). FT REGION 192 211 Partial activation of MRGPRA1. FT CARBOHYD 149 149 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 231 AA; 25377 MW; 56DC8F6C09F5EFC5 CRC64; MAVARHGYRP WGSILGLLGL ALAAAAAWDV ASLRCTFGSF CECDFWPDLP GLECDLAQHL AGQHLAKALV VKSLKAFVQD PAPSKPLVLS LHGWTGTGKS YVSSLLAQHL FRDGLRSPHV HHFSPIIHFP HPSRTEQYKK ELKSWVQGNL TACGRSLFLF DEMDKLPPGL MEVLQPFLGP SWVVYGTNYR KAIFIFIRWL LAVWHHGGAP AGRCGALPPA PAASRAPLRT Q //