ID   S35G6_HUMAN             Reviewed;         338 AA.
AC   P0C7Q6;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   28-JUN-2023, entry version 93.
DE   RecName: Full=Solute carrier family 35 member G6;
DE   AltName: Full=Acyl-malonyl-condensing enzyme 1-like protein 3;
DE   AltName: Full=Transmembrane protein 21B;
GN   Name=SLC35G6; Synonyms=AMAC1L3, TMEM21B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2]
RP   TISSUE SPECIFICITY, AND GENE EVOLUTION.
RX   PubMed=17101974; DOI=10.1073/pnas.0603224103;
RA   Xing J., Wang H., Belancio V.P., Cordaux R., Deininger P.L., Batzer M.A.;
RT   "Emergence of primate genes by retrotransposon-mediated sequence
RT   transduction.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:17608-17613(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in placenta and testis.
CC       {ECO:0000269|PubMed:17101974}.
CC   -!- MISCELLANEOUS: This gene appears to be the source locus of an SVA-
CC       mediated retrotransposition event that gave rise to SLC35G3, SLC35G4
CC       and SLC35G5 genes.
CC   -!- SIMILARITY: Belongs to the SLC35G solute transporter family.
CC       {ECO:0000305}.
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DR   EMBL; AC113189; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS45603.1; -.
DR   RefSeq; NP_001096084.1; NM_001102614.1.
DR   AlphaFoldDB; P0C7Q6; -.
DR   SMR; P0C7Q6; -.
DR   STRING; 9606.ENSP00000396523; -.
DR   TCDB; 2.A.7.28.6; the drug/metabolite transporter (dmt) superfamily.
DR   iPTMnet; P0C7Q6; -.
DR   PhosphoSitePlus; P0C7Q6; -.
DR   BioMuta; SLC35G6; -.
DR   DMDM; 193806690; -.
DR   PaxDb; P0C7Q6; -.
DR   Antibodypedia; 82013; 2 antibodies from 2 providers.
DR   DNASU; 643664; -.
DR   Ensembl; ENST00000412468.4; ENSP00000396523.2; ENSG00000259224.3.
DR   Ensembl; ENST00000639889.1; ENSP00000491424.1; ENSG00000284515.1.
DR   GeneID; 643664; -.
DR   KEGG; hsa:643664; -.
DR   MANE-Select; ENST00000412468.4; ENSP00000396523.2; NM_001102614.2; NP_001096084.1.
DR   UCSC; uc010cmj.2; human.
DR   AGR; HGNC:31351; -.
DR   CTD; 643664; -.
DR   GeneCards; SLC35G6; -.
DR   HGNC; HGNC:31351; SLC35G6.
DR   HPA; ENSG00000259224; Tissue enriched (testis).
DR   neXtProt; NX_P0C7Q6; -.
DR   PharmGKB; PA134919830; -.
DR   VEuPathDB; HostDB:ENSG00000259224; -.
DR   eggNOG; ENOG502RCFC; Eukaryota.
DR   GeneTree; ENSGT00940000153249; -.
DR   HOGENOM; CLU_055637_0_0_1; -.
DR   InParanoid; P0C7Q6; -.
DR   OMA; GCAYSSF; -.
DR   OrthoDB; 5265412at2759; -.
DR   PhylomeDB; P0C7Q6; -.
DR   TreeFam; TF331838; -.
DR   PathwayCommons; P0C7Q6; -.
DR   SignaLink; P0C7Q6; -.
DR   BioGRID-ORCS; 643664; 134 hits in 1047 CRISPR screens.
DR   GenomeRNAi; 643664; -.
DR   Pharos; P0C7Q6; Tdark.
DR   PRO; PR:P0C7Q6; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; P0C7Q6; protein.
DR   Bgee; ENSG00000259224; Expressed in right testis and 18 other tissues.
DR   Genevisible; P0C7Q6; HS.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   PANTHER; PTHR22911; ACYL-MALONYL CONDENSING ENZYME-RELATED; 1.
DR   PANTHER; PTHR22911:SF110; SOLUTE CARRIER FAMILY 35 MEMBER G3-RELATED; 1.
DR   SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 2.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..338
FT                   /note="Solute carrier family 35 member G6"
FT                   /id="PRO_0000342676"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          49..174
FT                   /note="EamA 1"
FT   DOMAIN          272..325
FT                   /note="EamA 2"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         51
FT                   /note="A -> T (in dbSNP:rs3760422)"
FT                   /id="VAR_044335"
FT   VARIANT         251
FT                   /note="P -> L (in dbSNP:rs4491591)"
FT                   /id="VAR_044336"
FT   VARIANT         263
FT                   /note="A -> T (in dbSNP:rs7209977)"
FT                   /id="VAR_059581"
SQ   SEQUENCE   338 AA;  35103 MW;  5E5E5D10245050C3 CRC64;
     MAGSHPYLNP PDSTHPSPPS APPSLRWHQC CQPSDATNGL LVALLGGGLP AGFVGPLSHM
     AYQASNLPSL ELLICRCLFH LPIALLLKLR GDPLLGPPDI RGRAYFYALL NVLSIGCAYS
     AVQVVPAGNA ATVRKGSSTV CSAVLTLCLE SQGLSGYDWC GLLGSILGLI IIVGPGLWTL
     QEGITGVYTA LGYGQAFVGG LALSLGLLVY RSLHFPSCLP TVAFLSGLVG LLGSVPGLFV
     LQPPVLPSDL PSWSCVGAVG ILALVSFTCV SYAVTKAHPA LVCAVLHSEV VVALILQYYM
     LHETVAPSDI VGAGVVLGSI AIITAWNLSC EREGKVEE
//