ID   CC175_HUMAN             Reviewed;         793 AA.
AC   P0C221; G3V5J7;
DT   14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   14-MAY-2014, sequence version 2.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Coiled-coil domain-containing protein 175;
GN   Name=CCDC175; Synonyms=C14orf38;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA   Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA   Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA   Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA   Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA   Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA   Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA   Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA   Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA   Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA   Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA   Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA   Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA   Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
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DR   EMBL; AL121694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS53898.1; -.
DR   RefSeq; NP_001157871.1; NM_001164399.1.
DR   AlphaFoldDB; P0C221; -.
DR   SMR; P0C221; -.
DR   BioGRID; 610063; 4.
DR   STRING; 9606.ENSP00000453940; -.
DR   iPTMnet; P0C221; -.
DR   PhosphoSitePlus; P0C221; -.
DR   BioMuta; CCDC175; -.
DR   DMDM; 117940155; -.
DR   EPD; P0C221; -.
DR   jPOST; P0C221; -.
DR   MassIVE; P0C221; -.
DR   PaxDb; P0C221; -.
DR   PeptideAtlas; P0C221; -.
DR   PRIDE; P0C221; -.
DR   ProteomicsDB; 33544; -.
DR   ProteomicsDB; 52300; -.
DR   Antibodypedia; 100; 8 antibodies from 7 providers.
DR   DNASU; 729665; -.
DR   Ensembl; ENST00000537690.7; ENSP00000453940.1; ENSG00000151838.12.
DR   GeneID; 729665; -.
DR   KEGG; hsa:729665; -.
DR   MANE-Select; ENST00000537690.7; ENSP00000453940.1; NM_001164399.2; NP_001157871.1.
DR   UCSC; uc021rtw.2; human.
DR   CTD; 729665; -.
DR   DisGeNET; 729665; -.
DR   GeneCards; CCDC175; -.
DR   HGNC; HGNC:19847; CCDC175.
DR   HPA; ENSG00000151838; Tissue enriched (brain).
DR   neXtProt; NX_P0C221; -.
DR   OpenTargets; ENSG00000151838; -.
DR   VEuPathDB; HostDB:ENSG00000151838; -.
DR   eggNOG; ENOG502RXX0; Eukaryota.
DR   GeneTree; ENSGT00390000001277; -.
DR   InParanoid; P0C221; -.
DR   OrthoDB; 1137420at2759; -.
DR   TreeFam; TF351236; -.
DR   PathwayCommons; P0C221; -.
DR   BioGRID-ORCS; 729665; 12 hits in 1068 CRISPR screens.
DR   ChiTaRS; CCDC175; human.
DR   GenomeRNAi; 729665; -.
DR   Pharos; P0C221; Tdark.
DR   PRO; PR:P0C221; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   RNAct; P0C221; protein.
DR   Bgee; ENSG00000151838; Expressed in right hemisphere of cerebellum and 72 other tissues.
DR   ExpressionAtlas; P0C221; baseline and differential.
DR   InterPro; IPR038834; CCDC175.
DR   PANTHER; PTHR35347; PTHR35347; 1.
PE   4: Predicted;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..793
FT                   /note="Coiled-coil domain-containing protein 175"
FT                   /id="PRO_0000259927"
FT   COILED          131..163
FT                   /evidence="ECO:0000255"
FT   COILED          205..377
FT                   /evidence="ECO:0000255"
FT   COILED          431..535
FT                   /evidence="ECO:0000255"
FT   COILED          562..679
FT                   /evidence="ECO:0000255"
FT   COILED          716..745
FT                   /evidence="ECO:0000255"
FT   VARIANT         164
FT                   /note="G -> R (in dbSNP:rs17834244)"
FT                   /id="VAR_050871"
FT   VARIANT         507
FT                   /note="G -> E (in dbSNP:rs4261431)"
FT                   /id="VAR_050872"
FT   VARIANT         689
FT                   /note="S -> N (in dbSNP:rs12887189)"
FT                   /id="VAR_050873"
FT   VARIANT         689
FT                   /note="S -> R (in dbSNP:rs4394993)"
FT                   /id="VAR_050874"
SQ   SEQUENCE   793 AA;  93626 MW;  550A4313A3FB487F CRC64;
     MALSPWTPGL GAGEKLVQAA AVSTGPSLEL CTLPSTLGSS VAVEALEQLF VVEQSLQSDY
     FKCNEEAKIF LKDIAVAVKK LEEMRKATID LLEIESMELN KLYYLLETLP NSIKRELEEC
     VRDARRLNLF EINTIKMRIT RTENEIELLK KKITDLTKYN EALGEKQEEL ARKHARFVLS
     LNQTMEKKAT TTVYINETYT KINLKREDIA LQKKCIQEAE ELMEKERAEY LIRKQELTAQ
     INEFENTREV KRMETYQKKK ELDKLQTKMS KIKETVTVSA AVLSDHNLEI ARLHESIRYW
     EQEVSELKKD LAILEAKLCF FTDNKEKLDD ISNDEKNEFL NKIKQLVETL HAARMEYKDL
     REKMKTLARQ YKIVLSEEEK AFLQKQKIHD ENQKQLTFIS QKEYFLSQKR VDIKNMEEGL
     ITLQELQQAT KTVYQQQIKI LSANLERESQ RCVITQWKMA CLRKKHARWT AKIKAEIQAI
     TEKIQNAEVR RIELLNETSF RQQEISGFVA QIEKLTTELK EEEKAFVNKE KMLMKELSKY
     EEIFVKETQI NKEKEEELVE YLPQLQVAEQ EYKEKRRKLE ELSNIITAQR QEEDLLNNHI
     FLFTRDFSRY ISNMEDVKQE LQQLRDQESK KNKDHFETLK NLENGFYIND QKADLLLLEN
     KKLKEYILYL KNNIEKYREG QEALMHTSSD LSRQLIAQEA QYKDLWAEFQ TTVKILVDNG
     EETLQDINNL TDKLRERDEK MQHVSTWLRG SLEGLRLLVE QESPMDLLKK KKHIRTRVHF
     PVVKCTEKNT LTK
//