ID RL7_SALTY Reviewed; 121 AA. AC P0A299; P18081; DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 2. DT 12-AUG-2020, entry version 94. DE RecName: Full=50S ribosomal protein L7/L12 {ECO:0000255|HAMAP-Rule:MF_00368}; DE AltName: Full=L8; GN Name=rplL {ECO:0000255|HAMAP-Rule:MF_00368}; OrderedLocusNames=STM4152; GN ORFNames=STMF1.11; OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720). OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Salmonella. OX NCBI_TaxID=99287; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=LT2; RX PubMed=2201953; DOI=10.1093/nar/18.15.4620; RA Zhyvoloup A.N., Woodmaska M.I., Kroupskaya I.V., Paton E.B.; RT "Nucleotide sequence of the rplJL operon and the deduced primary structure RT of the encoded L10 and L7/L12 proteins of Salmonella typhimurium compared RT to that of Escherichia coli."; RL Nucleic Acids Res. 18:4620-4620(1990). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=LT2; RX PubMed=2194828; DOI=10.1016/0014-5793(90)80901-t; RA Paton E.B., Woodmaska M.I., Kroupskaya I.V., Zhyvoloup A.N., Matsuka G.K.; RT "Evidence for the ability of L10 ribosomal proteins of Salmonella RT typhimurium and Klebsiella pneumoniae to regulate rplJL gene expression in RT Escherichia coli."; RL FEBS Lett. 265:129-132(1990). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=LT2 / SGSC1412 / ATCC 700720; RX PubMed=11677609; DOI=10.1038/35101614; RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E., RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., RA Wilson R.K.; RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."; RL Nature 413:852-856(2001). CC -!- FUNCTION: Forms part of the ribosomal stalk which helps the ribosome CC interact with GTP-bound translation factors. Is thus essential for CC accurate translation. {ECO:0000255|HAMAP-Rule:MF_00368}. CC -!- SUBUNIT: Homodimer. Part of the ribosomal stalk of the 50S ribosomal CC subunit. Forms a multimeric L10(L12)X complex, where L10 forms an CC elongated spine to which 2 to 4 L12 dimers bind in a sequential CC fashion. Binds GTP-bound translation factors. {ECO:0000255|HAMAP- CC Rule:MF_00368}. CC -!- PTM: Acetylation of Ser-2 converts L12 to L7. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the bacterial ribosomal protein bL12 family. CC {ECO:0000255|HAMAP-Rule:MF_00368}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X53072; CAA37246.1; -; Genomic_DNA. DR EMBL; AF170176; AAF33498.1; -; Genomic_DNA. DR EMBL; AE006468; AAL22980.1; -; Genomic_DNA. DR PIR; S12828; R5EB12. DR RefSeq; NP_463021.1; NC_003197.2. DR RefSeq; WP_000028882.1; NC_003197.2. DR PaxDb; P0A299; -. DR PRIDE; P0A299; -. DR EnsemblBacteria; AAL22980; AAL22980; STM4152. DR GeneID; 1255678; -. DR GeneID; 48351069; -. DR KEGG; stm:STM4152; -. DR PATRIC; fig|99287.12.peg.4364; -. DR HOGENOM; CLU_086499_3_2_6; -. DR KO; K02935; -. DR OMA; VDNAPKP; -. DR PhylomeDB; P0A299; -. DR BioCyc; SENT99287:STM4152-MONOMER; -. DR PRO; PR:P0A299; -. DR Proteomes; UP000001014; Chromosome. DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central. DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro. DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule. DR CDD; cd00387; Ribosomal_L7_L12; 1. DR Gene3D; 1.20.5.710; -; 1. DR Gene3D; 3.30.1390.10; -; 1. DR HAMAP; MF_00368; Ribosomal_L7_L12; 1. DR InterPro; IPR000206; Ribosomal_L7/12. DR InterPro; IPR014719; Ribosomal_L7/12_C/ClpS-like. DR InterPro; IPR013823; Ribosomal_L7/L12_C. DR InterPro; IPR008932; Ribosomal_L7/L12_oligo. DR InterPro; IPR036235; Ribosomal_L7/L12_oligo_N_sf. DR PANTHER; PTHR45987; PTHR45987; 1. DR Pfam; PF00542; Ribosomal_L12; 1. DR Pfam; PF16320; Ribosomal_L12_N; 1. DR SUPFAM; SSF48300; SSF48300; 1. DR SUPFAM; SSF54736; SSF54736; 1. DR TIGRFAMs; TIGR00855; L12; 1. PE 3: Inferred from homology; KW Acetylation; Reference proteome; Ribonucleoprotein; Ribosomal protein. FT INIT_MET 1 FT /note="Removed" FT /evidence="ECO:0000250" FT CHAIN 2..121 FT /note="50S ribosomal protein L7/L12" FT /id="PRO_0000157572" FT MOD_RES 2 FT /note="N-acetylserine; in form L7" FT /evidence="ECO:0000250" SQ SEQUENCE 121 AA; 12299 MW; 7FE04E5B79802D51 CRC64; MSITKDQIIE AVSAMSVMDV VELISAMEEK FGVSAAAAVA VAAGPAEAAE EKTEFDVILK AAGANKVAVI KAVRGATGLG LKEAKDLVES APAALKEGVS KDDAEALKKS LEEAGAEVEV K //