ID RL7_SALTY Reviewed; 121 AA. AC P0A299; P18081; DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 2. DT 15-MAR-2017, entry version 80. DE RecName: Full=50S ribosomal protein L7/L12 {ECO:0000255|HAMAP-Rule:MF_00368}; DE AltName: Full=L8; GN Name=rplL {ECO:0000255|HAMAP-Rule:MF_00368}; GN OrderedLocusNames=STM4152; ORFNames=STMF1.11; OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720). OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Salmonella. OX NCBI_TaxID=99287; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=LT2; RX PubMed=2201953; DOI=10.1093/nar/18.15.4620; RA Zhyvoloup A.N., Woodmaska M.I., Kroupskaya I.V., Paton E.B.; RT "Nucleotide sequence of the rplJL operon and the deduced primary RT structure of the encoded L10 and L7/L12 proteins of Salmonella RT typhimurium compared to that of Escherichia coli."; RL Nucleic Acids Res. 18:4620-4620(1990). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=LT2; RX PubMed=2194828; DOI=10.1016/0014-5793(90)80901-T; RA Paton E.B., Woodmaska M.I., Kroupskaya I.V., Zhyvoloup A.N., RA Matsuka G.K.; RT "Evidence for the ability of L10 ribosomal proteins of Salmonella RT typhimurium and Klebsiella pneumoniae to regulate rplJL gene RT expression in Escherichia coli."; RL FEBS Lett. 265:129-132(1990). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=LT2 / SGSC1412 / ATCC 700720; RX PubMed=11677609; DOI=10.1038/35101614; RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E., RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., RA Waterston R., Wilson R.K.; RT "Complete genome sequence of Salmonella enterica serovar Typhimurium RT LT2."; RL Nature 413:852-856(2001). CC -!- FUNCTION: Forms part of the ribosomal stalk which helps the CC ribosome interact with GTP-bound translation factors. Is thus CC essential for accurate translation. {ECO:0000255|HAMAP- CC Rule:MF_00368}. CC -!- SUBUNIT: Homodimer. Part of the ribosomal stalk of the 50S CC ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 CC forms an elongated spine to which 2 to 4 L12 dimers bind in a CC sequential fashion. Binds GTP-bound translation factors. CC {ECO:0000255|HAMAP-Rule:MF_00368}. CC -!- PTM: Acetylation of Ser-2 converts L12 to L7. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the ribosomal protein L7/L12P family. CC {ECO:0000255|HAMAP-Rule:MF_00368}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X53072; CAA37246.1; -; Genomic_DNA. DR EMBL; AF170176; AAF33498.1; -; Genomic_DNA. DR EMBL; AE006468; AAL22980.1; -; Genomic_DNA. DR PIR; S12828; R5EB12. DR RefSeq; NP_463021.1; NC_003197.2. DR RefSeq; WP_000028882.1; NC_003197.2. DR ProteinModelPortal; P0A299; -. DR SMR; P0A299; -. DR STRING; 99287.STM4152; -. DR PaxDb; P0A299; -. DR PRIDE; P0A299; -. DR EnsemblBacteria; AAL22980; AAL22980; STM4152. DR GeneID; 1255678; -. DR GeneID; 23336125; -. DR KEGG; stm:STM4152; -. DR PATRIC; 32387185; VBISalEnt20916_4364. DR eggNOG; ENOG4105KBC; Bacteria. DR eggNOG; COG0222; LUCA. DR HOGENOM; HOG000248813; -. DR KO; K02935; -. DR OMA; GLKETWG; -. DR PhylomeDB; P0A299; -. DR Proteomes; UP000001014; Chromosome. DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW. DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro. DR GO; GO:0006412; P:translation; IEA:InterPro. DR CDD; cd00387; Ribosomal_L7_L12; 1. DR Gene3D; 3.30.1390.10; -; 1. DR HAMAP; MF_00368; Ribosomal_L7_L12; 1. DR InterPro; IPR000206; Ribosomal_L7/12. DR InterPro; IPR014719; Ribosomal_L7/12_C/ClpS-like. DR InterPro; IPR013823; Ribosomal_L7/L12_C. DR InterPro; IPR008932; Ribosomal_L7/L12_oligo. DR PANTHER; PTHR24089:SF404; PTHR24089:SF404; 1. DR Pfam; PF00542; Ribosomal_L12; 1. DR Pfam; PF16320; Ribosomal_L12_N; 1. DR ProDom; PD001326; Ribosomal_L7/L12_C; 1. DR SUPFAM; SSF48300; SSF48300; 1. DR SUPFAM; SSF54736; SSF54736; 1. DR TIGRFAMs; TIGR00855; L12; 1. PE 3: Inferred from homology; KW Acetylation; Complete proteome; Reference proteome; Ribonucleoprotein; KW Ribosomal protein. FT INIT_MET 1 1 Removed. {ECO:0000250}. FT CHAIN 2 121 50S ribosomal protein L7/L12. FT /FTId=PRO_0000157572. FT MOD_RES 2 2 N-acetylserine; in form L7. FT {ECO:0000250}. SQ SEQUENCE 121 AA; 12299 MW; 7FE04E5B79802D51 CRC64; MSITKDQIIE AVSAMSVMDV VELISAMEEK FGVSAAAAVA VAAGPAEAAE EKTEFDVILK AAGANKVAVI KAVRGATGLG LKEAKDLVES APAALKEGVS KDDAEALKKS LEEAGAEVEV K //