ID TDT_MOUSE STANDARD; PRT; 529 AA. AC P09838; DT 01-MAR-1989 (REL. 10, CREATED) DT 01-MAR-1989 (REL. 10, LAST SEQUENCE UPDATE) DT 01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE) DE DNA NUCLEOTIDYLEXOTRANSFERASE (EC 2.7.7.31) (TERMINAL ADDITION ENZYME) DE (TERMINAL DEOXYNUCLEOTIDYLTRANSFERASE) (TDT) (TERMINAL TRANSFERASE). OS MUS MUSCULUS (MOUSE). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RM 86286588 RA KOIWAI O., YOKOTA T., KAGEYAMA T., HIROSE T., YOSHIDA S., ARAI K.; RL NUCLEIC ACIDS RES. 14:5777-5792(1986). CC -!- FUNCTION: TEMPLATE-INDEPENDENT DNA POLYMERASE WHICH CATALYZES THE CC RANDOM ADDITION OF DEOXYNUCLEOSIDE 5'-TRIPHOSPHATE TO THE 3'END OF CC A DNA INITIATOR. ONE OF THE IN-VIVO FUNCTION OF THIS ENZYME IS THE CC ADDITION OF NUCLEOTIDES AT THE JUNCTION OF REARRANGED IG HEAVY CC CHAIN AND T CELL RECEPTOR GENE SEGMENTS DURING THE MATURATION OF CC B AND T CELLS. CC -!- COFACTOR: REQUIRES MAGNESIUM. CC -!- CATALYTIC ACTIVITY: N DEOXYNUCLEOSIDE TRIPHOSPHATE + (DEOXY CC NUCLEOTIDE)(M) = N PYROPHOSPHATE + (DEOXYNUCLEOTIDE)(M+N). CC -!- SIMILARITY: BELONGS TO FAMILY X OF DNA POLYMERASES. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X04123; MMTDTR. DR PIR; B23595; B23595. DR PROSITE; PS00522; DNA_POLYMERASE_X. KW TRANSFERASE; NUCLEOTIDYLTRANSFERASE; TERMINAL ADDITION; MAGNESIUM. SQ SEQUENCE 529 AA; 60014 MW; 1425180 CN; MDPLQAVHLG PRKKRPRQLG TPVASTPYDI RFRDLVLFIL EKKMGTTRRA FLMELARRKG FRVENELSDS VTHIVAENNS GSDVLEWLQL QNIKASSELE LLDISWLIEC MGAGKPVEMM GRHQLVVNRN SSPSPVPGSQ NVPAPAVKKI SQYACQRRTT LNNYNQLFTD ALDILAENDE LRENEGSCLA FMGASSVLKS LPFPITSMKD TEGIPCLGDK VKSIIEGIIE DGESSEAKAV LNDERYKSFK LFTSVFGVGL KTAEKWFRMG FRTLSKIQSD KSLRFTKMQK AGFLYYEDLV SCVNRPEAQA VSMLVKEAVV TFLPDALVTM TGGFRRGKMT GHDVDFLITS PEATEDEEQQ LLHKVTHFWK QQGLLLYCDI LESTFEKFKQ PSRKVDALDH FQKCFLILKL DHGRVHSEKS GQQEGKGWKA IRVDLVMCPY ECACALLGWT GSRQFERDLR RYATHERKMM LDNHALYDRT KGKTVTISPL DGKVSKLQKA LRVFLEAESE EEIFAHLGLD YIEPWERNA //