ID TDT$MOUSE STANDARD; PRT; 529 AA. AC P09838; DT 01-MAR-1989 (REL. 10, CREATED) DT 01-MAR-1989 (REL. 10, LAST SEQUENCE UPDATE) DT 01-AUG-1991 (REL. 19, LAST ANNOTATION UPDATE) DE DNA NUCLEOTIDYLEXOTRANSFERASE (EC 2.7.7.31) (TERMINAL ADDITION DE ENZYME) (TERMINAL DEOXYNUCLEOTIDYLTRANSFERASE) (TDT) (TERMINAL DE TRANSFERASE). OS MUS MUSCULUS (MOUSE). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RC MEDLINE=86286588; RA KOIWAI O., YOKOTA T., KAGEYAMA T., HIROSE T., YOSHIDA S., ARAI K.; RL NUCLEIC ACIDS RES. 14:5777-5792(1986). CC -!- FUNCTION: TDT IS A MAGNESIUM-REQUIRING ENZYME WHICH CATALYZES THE CC POLYMERIZATION OF DEOXYNUCLEOSIDE TRIPHOSPHATES, ELONGATING CC POLYDEOXYNUCLEOTIDE CHAINS BY TERMINAL ADDITION; IT IS DISTINCT CC FROM THE REPLICATIVE DEOXYNUCLEOTIDYLTRANSFERASE (DNA POLYMERASE), CC WHICH IS ABLE TO COPY A TEMPLATE. CC -!- CATALYTIC ACTIVITY: N DEOXYNUCLEOSIDE TRIPHOSPHATE + (DEOXY CC NUCLEOTIDE)(M) = N PYROPHOSPHATE + (DEOXYNUCLEOTIDE)(M+N). CC -!- SIMILARITY: BELONGS TO FAMILY X OF DNA POLYMERASES. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X04123; MMTDTR. DR PIR; B23595; B23595. DR PROSITE; PS00522; DNA_POLYMERASE_X. KW TRANSFERASE; NUCLEOTIDYLTRANSFERASE; TERMINAL ADDITION; MAGNESIUM. SQ SEQUENCE 529 AA; 60014 MW; 1425180 CN; MDPLQAVHLG PRKKRPRQLG TPVASTPYDI RFRDLVLFIL EKKMGTTRRA FLMELARRKG FRVENELSDS VTHIVAENNS GSDVLEWLQL QNIKASSELE LLDISWLIEC MGAGKPVEMM GRHQLVVNRN SSPSPVPGSQ NVPAPAVKKI SQYACQRRTT LNNYNQLFTD ALDILAENDE LRENEGSCLA FMGASSVLKS LPFPITSMKD TEGIPCLGDK VKSIIEGIIE DGESSEAKAV LNDERYKSFK LFTSVFGVGL KTAEKWFRMG FRTLSKIQSD KSLRFTKMQK AGFLYYEDLV SCVNRPEAQA VSMLVKEAVV TFLPDALVTM TGGFRRGKMT GHDVDFLITS PEATEDEEQQ LLHKVTHFWK QQGLLLYCDI LESTFEKFKQ PSRKVDALDH FQKCFLILKL DHGRVHSEKS GQQEGKGWKA IRVDLVMCPY ECACALLGWT GSRQFERDLR RYATHERKMM LDNHALYDRT KGKTVTISPL DGKVSKLQKA LRVFLEAESE EEIFAHLGLD YIEPWERNA //