ID US27_HCMVA Reviewed; 362 AA. AC P09703; Q7M6H4; DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1989, sequence version 1. DT 02-MAR-2010, entry version 73. DE RecName: Full=G-protein coupled receptor homolog US27; DE AltName: Full=HHRF2; GN Name=US27; OS Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5). OC Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; OC Betaherpesvirinae; Cytomegalovirus. OX NCBI_TaxID=10360; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=87169717; PubMed=3031311; DOI=10.1016/0022-2836(86)90359-1; RA Weston K.M., Barrell B.G.; RT "Sequence of the short unique region, short repeats, and part of the RT long repeats of human cytomegalovirus."; RL J. Mol. Biol. 192:177-208(1986). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=90269039; PubMed=2161319; RA Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., RA Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., RA Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.; RT "Analysis of the protein-coding content of the sequence of human RT cytomegalovirus strain AD169."; RL Curr. Top. Microbiol. Immunol. 154:125-169(1990). RN [3] RP SIMILARITY TO G-PROTEIN COUPLED RECEPTORS. RX MEDLINE=90231415; PubMed=2158627; DOI=10.1038/344774a0; RA Chee M.S., Satchwell S.C., Preddie E., Weston K.M., Barrell B.G.; RT "Human cytomegalovirus encodes three G protein-coupled receptor RT homologues."; RL Nature 344:774-777(1990). RN [4] RP GENOME REANNOTATION. RX MEDLINE=22421467; PubMed=12533697; DOI=10.1099/vir.0.18606-0; RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., RA Alcendor D.J., McGeoch D.J., Hayward G.S.; RT "The human cytomegalovirus genome revisited: comparison with the RT chimpanzee cytomegalovirus genome."; RL J. Gen. Virol. 84:17-28(2003). RN [5] RP ERRATUM. RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., RA Alcendor D.J., McGeoch D.J., Hayward G.S.; RL J. Gen. Virol. 84:1053-1053(2003). RN [6] RP IDENTIFICATION. RX PubMed=15452216; DOI=10.1128/JVI.78.20.10960-10966.2004; RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., RA Shenk T., Smith R.D., Nelson J.A.; RT "Identification of proteins in human cytomegalovirus (HCMV) particles: RT the HCMV proteome."; RL J. Virol. 78:10960-10966(2004). RN [7] RP ERRATUM. RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., RA Shenk T., Smith R.D., Nelson J.A.; RL J. Virol. 78:13395-13395(2004). CC -!- FUNCTION: Regulation of HCMV latency or reactivation; potential CC pathway for virally transformed cell proliferation. CC -!- SUBCELLULAR LOCATION: Virion. Host cell membrane; Multi-pass CC membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X17403; CAA35259.1; -; Genomic_DNA. DR EMBL; X04650; CAA28337.1; -; Genomic_DNA. DR EMBL; BK000394; DAA00214.1; -; Genomic_DNA. DR PIR; B27216; QQBED2. DR SMR; P09703; 35-335. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell. DR GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; IEA:UniProtKB-KW. DR InterPro; IPR000276; 7TM_GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_supfam. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Complete proteome; G-protein coupled receptor; Glycoprotein; KW Host cell membrane; Host membrane; Membrane; Receptor; Transducer; KW Transmembrane; Virion. FT CHAIN 1 362 G-protein coupled receptor homolog US27. FT /FTId=PRO_0000070245. FT TOPO_DOM 1 34 Extracellular (Potential). FT TRANSMEM 35 58 1 (Potential). FT TOPO_DOM 59 67 Cytoplasmic (Potential). FT TRANSMEM 68 90 2 (Potential). FT TOPO_DOM 91 104 Extracellular (Potential). FT TRANSMEM 105 126 3 (Potential). FT TOPO_DOM 127 148 Cytoplasmic (Potential). FT TRANSMEM 149 167 4 (Potential). FT TOPO_DOM 168 193 Extracellular (Potential). FT TRANSMEM 194 213 5 (Potential). FT TOPO_DOM 214 233 Cytoplasmic (Potential). FT TRANSMEM 234 257 6 (Potential). FT TOPO_DOM 258 274 Extracellular (Potential). FT TRANSMEM 275 298 7 (Potential). FT TOPO_DOM 299 362 Cytoplasmic (Potential). FT CARBOHYD 7 7 N-linked (GlcNAc...); by host FT (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...); by host FT (Potential). FT CARBOHYD 18 18 N-linked (GlcNAc...); by host FT (Potential). FT CARBOHYD 22 22 N-linked (GlcNAc...); by host FT (Potential). SQ SEQUENCE 362 AA; 41994 MW; D4C22064001EFECA CRC64; MTTSTNNQTL TQVSNMTNHT LNSTEIYQLF EYTRLGVWLM CIVGTFLNVL VITTILYYRR KKKSPSDTYI CNLAVADLLI VVGLPFFLEY AKHHPKLSRE VVCSGLNACF YICLFAGVCF LINLSMDRYC VIVWGVELNR VRNNKRATCW VVIFWILAVL MGMPHYLMYS HTNNECVGEF ANETSGWFPV FLNTKVNICG YLAPIALMAY TYNRMVRFII NYVGKWHMQT LHVLLVVVVS FASFWFPFNL ALFLESIRLL AGVYNDTLQN VIIFCLYVGQ FLAYVRACLN PGIYILVGTQ MRKDMWTTLR VFACCCVKQE IPYQDIDIEL QKDIQRRAKH TKRTHYDRKN APMESGEEEF LL //