ID US27_HCMVA STANDARD; PRT; 362 AA. AC P09703; Q7M6H4; DT 01-MAR-1989 (Rel. 10, Created) DT 01-MAR-1989 (Rel. 10, Last sequence update) DT 01-MAY-2005 (Rel. 47, Last annotation update) DE G-protein coupled receptor homolog US27 (HHRF2). GN Name=US27; OS Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5). OC Viruses; dsDNA viruses, no RNA stage; Herpesviridae; OC Betaherpesvirinae; Cytomegalovirus. OX NCBI_TaxID=10360; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=87169717; PubMed=3031311; RA Weston K.M., Barrell B.G.; RT "Sequence of the short unique region, short repeats, and part of the RT long repeats of human cytomegalovirus."; RL J. Mol. Biol. 192:177-208(1986). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=90269039; PubMed=2161319; RA Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., RA Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., RA Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.; RT "Analysis of the protein-coding content of the sequence of human RT cytomegalovirus strain AD169."; RL Curr. Top. Microbiol. Immunol. 154:125-169(1990). RN [3] RP SIMILARITY TO G-PROTEIN COUPLED RECEPTORS. RX MEDLINE=90231415; PubMed=2158627; DOI=10.1038/344774a0; RA Chee M.S., Satchwell S.C., Preddie E., Weston K.M., Barrell B.G.; RT "Human cytomegalovirus encodes three G protein-coupled receptor RT homologues."; RL Nature 344:774-777(1990). RN [4] RP GENOME REANNOTATION. RX MEDLINE=22421467; PubMed=12533697; DOI=10.1099/vir.0.18606-0; RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., RA Alcendor D.J., McGeoch D.J., Hayward G.S.; RT "The human cytomegalovirus genome revisited: comparison with the RT chimpanzee cytomegalovirus genome."; RL J. Gen. Virol. 84:17-28(2003). RN [5] RP ERRATUM. RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., RA Alcendor D.J., McGeoch D.J., Hayward G.S.; RL J. Gen. Virol. 84:1053-1053(2003). RN [6] RP IDENTIFICATION. RX PubMed=15452216; DOI=10.1128/JVI.78.20.10960-10966.2004; RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., RA Shenk T., Smith R.D., Nelson J.A.; RT "Identification of proteins in human cytomegalovirus (HCMV) particles: RT the HCMV proteome."; RL J. Virol. 78:10960-10966(2004). RN [7] RP ERRATUM. RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., RA Shenk T., Smith R.D., Nelson J.A.; RL J. Virol. 78:13395-13395(2004). CC -!- FUNCTION: Regulation of HCMV latency or reactivation?; potential CC pathway for virally transformed cell proliferation. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- MISCELLANEOUS: Found in the virion. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X17403; CAA35259.1; -. DR EMBL; X04650; CAA28337.1; -. DR EMBL; BK000394; DAA00214.1; -. DR PIR; B27216; QQBED2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR011040; Sialidase. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Receptor; KW Structural protein; Transducer; Transmembrane. FT DOMAIN 1 34 Extracellular (Potential). FT TRANSMEM 35 58 1 (Potential). FT DOMAIN 59 67 Cytoplasmic (Potential). FT TRANSMEM 68 90 2 (Potential). FT DOMAIN 91 104 Extracellular (Potential). FT TRANSMEM 105 126 3 (Potential). FT DOMAIN 127 148 Cytoplasmic (Potential). FT TRANSMEM 149 167 4 (Potential). FT DOMAIN 168 193 Extracellular (Potential). FT TRANSMEM 194 213 5 (Potential). FT DOMAIN 214 233 Cytoplasmic (Potential). FT TRANSMEM 234 257 6 (Potential). FT DOMAIN 258 274 Extracellular (Potential). FT TRANSMEM 275 298 7 (Potential). FT DOMAIN 299 362 Cytoplasmic (Potential). FT CARBOHYD 7 7 N-linked (GlcNAc...) (Potential). FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential). FT CARBOHYD 18 18 N-linked (GlcNAc...) (Potential). FT CARBOHYD 22 22 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 362 AA; 41994 MW; D4C22064001EFECA CRC64; MTTSTNNQTL TQVSNMTNHT LNSTEIYQLF EYTRLGVWLM CIVGTFLNVL VITTILYYRR KKKSPSDTYI CNLAVADLLI VVGLPFFLEY AKHHPKLSRE VVCSGLNACF YICLFAGVCF LINLSMDRYC VIVWGVELNR VRNNKRATCW VVIFWILAVL MGMPHYLMYS HTNNECVGEF ANETSGWFPV FLNTKVNICG YLAPIALMAY TYNRMVRFII NYVGKWHMQT LHVLLVVVVS FASFWFPFNL ALFLESIRLL AGVYNDTLQN VIIFCLYVGQ FLAYVRACLN PGIYILVGTQ MRKDMWTTLR VFACCCVKQE IPYQDIDIEL QKDIQRRAKH TKRTHYDRKN APMESGEEEF LL //