ID IE4_VZVD Reviewed; 452 AA. AC P09269; DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1989, sequence version 1. DT 01-JUL-2008, entry version 33. DE Transcriptional transactivator IE4 (Immediate-early protein 4) (IE4). GN Name=4; OS Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3). OC Viruses; dsDNA viruses, no RNA stage; Herpesviridae; OC Alphaherpesvirinae; Varicellovirus. OX NCBI_TaxID=10338; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=86306657; PubMed=3018124; RA Davison A.J., Scott J.E.; RT "The complete DNA sequence of varicella-zoster virus."; RL J. Gen. Virol. 67:1759-1816(1986). RN [2] RP INTERACTION WITH IE62. RX PubMed=10873781; DOI=10.1006/viro.2000.0389; RA Spengler M.L., Ruyechan W.T., Hay J.; RT "Physical interaction between two varicella zoster virus gene RT regulatory proteins, IE4 and IE62."; RL Virology 272:375-381(2000). CC -!- SUBUNIT: Interacts with transcriptional transactivator IE62. CC -!- INDUCTION: Immediate early (EI) protein. CC -!- SIMILARITY: Belongs to the herpesviridae UL69 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X04370; CAA27887.1; -; Genomic_DNA. DR PIR; D27212; WZBE4. DR RefSeq; NP_040127.1; -. DR GeneID; 1487672; -. DR InterPro; IPR008648; Herpes_UL69. DR Pfam; PF05459; Herpes_UL69; 1. PE 1: Evidence at protein level; KW Host-virus interaction; Transcription; Transcription regulation. FT CHAIN 1 452 Transcriptional transactivator IE4. FT /FTId=PRO_0000115831. SQ SEQUENCE 452 AA; 51543 MW; 42926E4A71E380B4 CRC64; MASASIPTDP DVSTICEDFM NLLPDEPSDD FALEVTDWAN DEAIGSTPGE DSTTSRTVYV ERTADTAYNP RYSKRRHGRR ESYHHNRPKT LVVVLPDSNH HGGRDVETGY ARIERGHRRS SRSYNTQSSR KHRDRSLSNR RRRPTTPPAM TTGERNDQTH DESYRLRFSK RDARRERIRK EYDIPVDRIT GRAIEVVSTA GASVTIDSVR HLDETIEKLV VRYATIQEGD SWASGGCFPG IKQNTSWPEL MLYGHELYRT FESYKMDSRI ARALRERVIR GESLIEALES ADELLTWIKM LAAKNLPIYT NNPIVATSKS LLENLKLKLG PFVRCLLLNR DNDLGSRTLP ELLRQQRFSD ITCITTYMFV MIARIANIVV RGSKFVEYDD ISCNVQVLQE YTPGSCLAGV LEALITHQRE CGRVECTLST WAGHLSDARP YGKYFKCSTF NC //