ID PO2F2_HUMAN Reviewed; 479 AA. AC P09086; Q16648; Q7M4M8; Q9BRS4; DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 3. DT 22-NOV-2017, entry version 194. DE RecName: Full=POU domain, class 2, transcription factor 2; DE AltName: Full=Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; DE AltName: Full=Octamer-binding protein 2; DE Short=Oct-2; DE AltName: Full=Octamer-binding transcription factor 2; DE Short=OTF-2; GN Name=POU2F2; Synonyms=OCT2, OTF2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE [MRNA] RP OF 450-479 (ISOFORM 1). RX PubMed=3265124; DOI=10.1101/gad.2.12a.1570; RA Clerc R.G., Corcoran L.M., Lebowitz J.H., Baltimore D., Sharp P.A.; RT "The B-cell-specific Oct-2 protein contains POU box- and homeo box- RT type domains."; RL Genes Dev. 2:1570-1581(1988). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, AND TISSUE RP SPECIFICITY. RC TISSUE=B-cell lymphoma; RX PubMed=2904654; DOI=10.1038/336551a0; RA Scheidereit C., Cromlish J.A., Gerster T., Kawakami K., RA Balmaceda C.-G., Currie R.A., Roder R.G.; RT "A human lymphoid-specific transcription factor that activates RT immunoglobulin genes is a homoeobox protein."; RL Nature 336:551-557(1988). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) system donor RT vector."; RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). RC TISSUE=Lymph; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] OF 2-479 (ISOFORM 1). RC TISSUE=B-cell; RX PubMed=2904653; DOI=10.1038/336544a0; RA Mueller M.M., Ruppert S., Schaffner W., Matthias P.; RT "A cloned octamer transcription factor stimulates transcription from RT lymphoid-specific promoters in non-B cells."; RL Nature 336:544-551(1988). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] OF 99-161, AND FUNCTION. RX PubMed=2328728; RA Muller-Immergluck M.M., Schaffner W., Matthias P.; RT "Transcription factor Oct-2A contains functionally redundant RT activating domains and works selectively from a promoter but not from RT a remote enhancer position in non-lymphoid (HeLa) cells."; RL EMBO J. 9:1625-1634(1990). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 168-377. RX PubMed=7888080; DOI=10.1515/bchm3.1994.375.10.675; RA Matsuo K., Clay O., Kuenzler P., Georgiev O., Urbanek P., RA Schaffner W.; RT "Short introns interrupting the Oct-2 POU domain may prevent RT recombination between POU family genes without interfering with RT potential POU domain 'shuffling' in evolution."; RL Biol. Chem. Hoppe-Seyler 375:675-683(1994). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] OF 240-387, AND FUNCTION. RX PubMed=2901913; DOI=10.1016/0092-8674(88)90016-5; RA Ko H.-S., Fast P., McBride W., Staudt L.M.; RT "A human protein specific for the immunoglobulin octamer DNA motif RT contains a functional homeobox domain."; RL Cell 55:135-144(1988). RN [9] RP NUCLEOTIDE SEQUENCE [MRNA] OF 468-479 (ISOFORM 5), AND FUNCTION. RX PubMed=1739980; DOI=10.1016/0092-8674(92)90150-B; RA Tanaka M., Lai J.-S., Herr W.; RT "Promoter-selective activation domains in Oct-1 and Oct-2 direct RT differential activation of an snRNA and mRNA promoter."; RL Cell 68:755-767(1992). RN [10] RP IDENTIFICATION (ISOFORM 5), AND TISSUE SPECIFICITY. RX PubMed=3072196; RA Schreiber E., Matthias P., Mueller M.M., Schaffner W.; RT "Identification of a novel lymphoid specific octamer binding protein RT (OTF-2B) by proteolytic clipping bandshift assay (PCBA)."; RL EMBO J. 7:4221-4229(1988). RN [11] RP INTERACTION WITH NR3C1; AR AND PGR. RX PubMed=10480874; DOI=10.1074/jbc.274.38.26713; RA Prefontaine G.G., Walther R., Giffin W., Lemieux M.E., Pope L., RA Hache R.J.G.; RT "Selective binding of steroid hormone receptors to octamer RT transcription factors determines transcriptional synergism at the RT mouse mammary tumor virus promoter."; RL J. Biol. Chem. 274:26713-26719(1999). RN [12] RP STRUCTURE BY NMR OF 297-359. RX PubMed=7914745; DOI=10.1021/bi00199a005; RA Sivaraja M., Botfield M.C., Mueller M., Jancso A., Weiss M.A.; RT "Solution structure of a POU-specific homeodomain: 3D-NMR studies of RT human B-cell transcription factor Oct-2."; RL Biochemistry 33:9845-9855(1994). CC -!- FUNCTION: Transcription factor that specifically binds to the CC octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a CC number of tissues in addition to activating immunoglobulin gene CC expression. Modulates transcription transactivation by NR3C1, AR CC and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) CC promoter. {ECO:0000269|PubMed:1739980, ECO:0000269|PubMed:2328728, CC ECO:0000269|PubMed:2901913, ECO:0000269|PubMed:2904654}. CC -!- SUBUNIT: Interacts with NR3C1, AR and PGR. CC {ECO:0000269|PubMed:10480874}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=5; CC Name=1; CC IsoId=P09086-1; Sequence=Displayed; CC Name=2; CC IsoId=P09086-2; Sequence=VSP_002325; CC Name=3; CC IsoId=P09086-3; Sequence=VSP_002324; CC Name=4; CC IsoId=P09086-4; Sequence=VSP_002324, VSP_007848, VSP_007849; CC Name=5; Synonyms=Oct-2B; CC IsoId=P09086-5; Sequence=VSP_032187; CC Note=Incomplete sequence.; CC -!- TISSUE SPECIFICITY: Isoform 3 is B-cell specific. Isoform 5 is CC expressed in B-cells and the immunoglobulin-expressing T-cell line CC MOLT-4, but not in the T-cell line BW5147. CC {ECO:0000269|PubMed:2904654, ECO:0000269|PubMed:3072196}. CC -!- SIMILARITY: Belongs to the POU transcription factor family. Class- CC 2 subfamily. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=CAA32039.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M36653; AAA36389.1; -; mRNA. DR EMBL; X53468; CAA37562.1; -; mRNA. DR EMBL; X53469; CAA37565.1; -; mRNA. DR EMBL; M36542; AAA36732.1; -; mRNA. DR EMBL; X13810; CAA32040.1; -; mRNA. DR EMBL; BT007438; AAP36106.1; -; mRNA. DR EMBL; BC006101; AAH06101.1; -; mRNA. DR EMBL; M36718; AAA59978.1; -; mRNA. DR EMBL; X13809; CAA32039.1; ALT_INIT; mRNA. DR EMBL; X81030; CAA56933.1; -; Genomic_DNA. DR CCDS; CCDS33035.1; -. [P09086-3] DR CCDS; CCDS56094.1; -. [P09086-2] DR CCDS; CCDS56095.1; -. [P09086-1] DR CCDS; CCDS58665.1; -. [P09086-4] DR PIR; A31753; A31753. DR PIR; A42098; A42098. DR RefSeq; NP_001193954.1; NM_001207025.2. [P09086-1] DR RefSeq; NP_001193955.1; NM_001207026.1. [P09086-2] DR RefSeq; NP_001234923.1; NM_001247994.1. [P09086-4] DR RefSeq; NP_002689.1; NM_002698.4. [P09086-3] DR UniGene; Hs.147381; -. DR PDB; 1HDP; NMR; -; A=297-359. DR PDBsum; 1HDP; -. DR ProteinModelPortal; P09086; -. DR SMR; P09086; -. DR BioGrid; 111448; 19. DR CORUM; P09086; -. DR DIP; DIP-51N; -. DR IntAct; P09086; 6. DR MINT; MINT-194986; -. DR STRING; 9606.ENSP00000431603; -. DR BindingDB; P09086; -. DR ChEMBL; CHEMBL3509582; -. DR DrugBank; DB08930; Dolutegravir. DR iPTMnet; P09086; -. DR PhosphoSitePlus; P09086; -. DR BioMuta; POU2F2; -. DR DMDM; 123402; -. DR MaxQB; P09086; -. DR PaxDb; P09086; -. DR PeptideAtlas; P09086; -. DR PRIDE; P09086; -. DR DNASU; 5452; -. DR Ensembl; ENST00000389341; ENSP00000373992; ENSG00000028277. [P09086-3] DR Ensembl; ENST00000526816; ENSP00000431603; ENSG00000028277. [P09086-1] DR Ensembl; ENST00000529067; ENSP00000437224; ENSG00000028277. [P09086-4] DR Ensembl; ENST00000529952; ENSP00000436988; ENSG00000028277. [P09086-2] DR GeneID; 5452; -. DR KEGG; hsa:5452; -. DR UCSC; uc002osn.4; human. [P09086-1] DR CTD; 5452; -. DR DisGeNET; 5452; -. DR EuPathDB; HostDB:ENSG00000028277.20; -. DR GeneCards; POU2F2; -. DR HGNC; HGNC:9213; POU2F2. DR HPA; CAB002513; -. DR HPA; HPA040368; -. DR HPA; HPA062096; -. DR HPA; HPA064404; -. DR MIM; 164176; gene. DR neXtProt; NX_P09086; -. DR OpenTargets; ENSG00000028277; -. DR PharmGKB; PA33537; -. DR eggNOG; KOG3802; Eukaryota. DR eggNOG; ENOG410XQ7X; LUCA. DR GeneTree; ENSGT00760000118935; -. DR HOGENOM; HOG000220842; -. DR HOVERGEN; HBG052783; -. DR InParanoid; P09086; -. DR KO; K09364; -. DR PhylomeDB; P09086; -. DR TreeFam; TF316413; -. DR Reactome; R-HSA-6807505; RNA polymerase II transcribes snRNA genes. DR SIGNOR; P09086; -. DR ChiTaRS; POU2F2; human. DR EvolutionaryTrace; P09086; -. DR GenomeRNAi; 5452; -. DR PRO; PR:P09086; -. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000028277; -. DR CleanEx; HS_POU2F2; -. DR ExpressionAtlas; P09086; baseline and differential. DR Genevisible; P09086; HS. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA. DR GO; GO:0005654; C:nucleoplasm; IDA:HPA. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl. DR GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Ensembl. DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI. DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; TAS:ProtInc. DR GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IEA:Ensembl. DR GO; GO:0048469; P:cell maturation; IEA:Ensembl. DR GO; GO:0006959; P:humoral immune response; TAS:ProtInc. DR GO; GO:0002380; P:immunoglobulin secretion involved in immune response; IEA:Ensembl. DR GO; GO:0002335; P:mature B cell differentiation; IEA:Ensembl. DR GO; GO:0042795; P:snRNA transcription from RNA polymerase II promoter; TAS:Reactome. DR GO; GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. DR CDD; cd00086; homeodomain; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf. DR InterPro; IPR013847; POU. DR InterPro; IPR000327; POU_dom. DR InterPro; IPR000972; TF_octamer. DR Pfam; PF00046; Homeobox; 1. DR Pfam; PF00157; Pou; 1. DR PRINTS; PR00029; OCTAMER. DR PRINTS; PR00028; POUDOMAIN. DR SMART; SM00389; HOX; 1. DR SMART; SM00352; POU; 1. DR SUPFAM; SSF46689; SSF46689; 1. DR SUPFAM; SSF47413; SSF47413; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. DR PROSITE; PS00035; POU_1; 1. DR PROSITE; PS00465; POU_2; 1. DR PROSITE; PS51179; POU_3; 1. PE 1: Evidence at protein level; KW 3D-structure; Activator; Alternative splicing; Complete proteome; KW Cytoplasm; DNA-binding; Homeobox; Nucleus; Reference proteome; KW Transcription; Transcription regulation. FT CHAIN 1 479 POU domain, class 2, transcription factor FT 2. FT /FTId=PRO_0000100714. FT DOMAIN 195 269 POU-specific. {ECO:0000255|PROSITE- FT ProRule:PRU00530}. FT DNA_BIND 297 356 Homeobox. {ECO:0000255|PROSITE- FT ProRule:PRU00108}. FT REGION 389 410 Leucine-zipper. FT COMPBIAS 417 424 Gly-rich. FT VAR_SEQ 168 183 Missing (in isoform 3 and isoform 4). FT {ECO:0000303|PubMed:15489334, FT ECO:0000303|PubMed:2904654, FT ECO:0000303|Ref.3}. FT /FTId=VSP_002324. FT VAR_SEQ 400 416 VTTLSSAVGTLHPSRTA -> AQTPALKAATRLSACQA FT (in isoform 4). FT {ECO:0000303|PubMed:15489334, FT ECO:0000303|Ref.3}. FT /FTId=VSP_007848. FT VAR_SEQ 417 479 Missing (in isoform 4). FT {ECO:0000303|PubMed:15489334, FT ECO:0000303|Ref.3}. FT /FTId=VSP_007849. FT VAR_SEQ 468 479 Missing (in isoform 2). FT {ECO:0000303|PubMed:3265124}. FT /FTId=VSP_002325. FT VAR_SEQ 468 479 PGLWWNPAPYQP -> STMVGLSSGLSPALMSNNPLATIQA FT LASGGTLPLTSLDGSGNLVLGAAGAAPGSPSLVTSPLFLNH FT TGLPLLSAPPGVGLVSAAAAAVAASISSKSPGLSSSSSSSS FT SSSSSTCSDVAAQTPGGPGGPEAGSKAE (in isoform FT 5). {ECO:0000303|PubMed:1739980}. FT /FTId=VSP_032187. FT MUTAGEN 340 342 VIR->FNP: Suppresses DNA-binding ability. FT HELIX 307 318 {ECO:0000244|PDB:1HDP}. FT HELIX 324 331 {ECO:0000244|PDB:1HDP}. FT TURN 332 335 {ECO:0000244|PDB:1HDP}. FT HELIX 338 350 {ECO:0000244|PDB:1HDP}. FT TURN 356 358 {ECO:0000244|PDB:1HDP}. SQ SEQUENCE 479 AA; 51209 MW; 8DA661DC07644D43 CRC64; MVHSSMGAPE IRMSKPLEAE KQGLDSPSEH TDTERNGPDT NHQNPQNKTS PFSVSPTGPS TKIKAEDPSG DSAPAAPLPP QPAQPHLPQA QLMLTGSQLA GDIQQLLQLQ QLVLVPGHHL QPPAQFLLPQ AQQSQPGLLP TPNLFQLPQQ TQGALLTSQP RAGLPTQAVT RPTLPDPHLS HPQPPKCLEP PSHPEEPSDL EELEQFARTF KQRRIKLGFT QGDVGLAMGK LYGNDFSQTT ISRFEALNLS FKNMCKLKPL LEKWLNDAET MSVDSSLPSP NQLSSPSLGF DGLPGRRRKK RTSIETNVRF ALEKSFLANQ KPTSEEILLI AEQLHMEKEV IRVWFCNRRQ KEKRINPCSA APMLPSPGKP ASYSPHMVTP QGGAGTLPLS QASSSLSTTV TTLSSAVGTL HPSRTAGGGG GGGGAAPPLN SIPSVTPPPP ATTNSTNPSP QGSHSAIGLS GLNPSTGPGL WWNPAPYQP //