ID   HXC4_HUMAN              Reviewed;         264 AA.
AC   P09017;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2009, sequence version 2.
DT   02-DEC-2020, entry version 195.
DE   RecName: Full=Homeobox protein Hox-C4;
DE   AltName: Full=Homeobox protein CP19;
DE   AltName: Full=Homeobox protein Hox-3E;
GN   Name=HOXC4; Synonyms=HOX3E;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2898768; DOI=10.1093/nar/16.12.5379;
RA   Simeone A., Pannese M., Acampora D., D'Esposito M., Boncinelli E.;
RT   "At least three human homeoboxes on chromosome 12 belong to the same
RT   transcription unit.";
RL   Nucleic Acids Res. 16:5379-5390(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11857506; DOI=10.1002/tera.10009;
RA   Kosaki K., Kosaki R., Suzuki T., Yoshihashi H., Takahashi T., Sasaki K.,
RA   Tomita M., McGinnis W., Matsuo N.;
RT   "Complete mutation analysis panel of the 39 human HOX genes.";
RL   Teratology 65:50-62(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA   Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA   Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA   Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA   Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA   Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA   Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA   Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA   Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA   Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA   Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA   Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA   Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA   David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA   D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA   Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA   Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA   Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA   LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA   Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA   Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA   Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA   Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA   Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA   Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA   Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA   Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA   Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA   Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA   Gibbs R.A.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 156-221.
RX   PubMed=2576652; DOI=10.1139/g89-133;
RA   Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R.,
RA   Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.;
RT   "Organization of human class I homeobox genes.";
RL   Genome 31:745-756(1989).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- INTERACTION:
CC       P09017; P49761: CLK3; NbExp=3; IntAct=EBI-3923226, EBI-745579;
CC       P09017; P68400: CSNK2A1; NbExp=3; IntAct=EBI-3923226, EBI-347804;
CC       P09017; Q9NQT4: EXOSC5; NbExp=3; IntAct=EBI-3923226, EBI-371876;
CC       P09017; O43639: NCK2; NbExp=3; IntAct=EBI-3923226, EBI-713635;
CC       P09017; Q9BZ95: NSD3; NbExp=2; IntAct=EBI-3923226, EBI-3390132;
CC       P09017; Q9NQG5: RPRD1B; NbExp=3; IntAct=EBI-3923226, EBI-747925;
CC       P09017; O43463: SUV39H1; NbExp=2; IntAct=EBI-3923226, EBI-349968;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Deformed subfamily.
CC       {ECO:0000305}.
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DR   EMBL; X07495; CAA30376.1; -; mRNA.
DR   EMBL; AY014298; AAG42145.1; -; Genomic_DNA.
DR   EMBL; AY014297; AAG42145.1; JOINED; Genomic_DNA.
DR   EMBL; AC023794; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS8873.1; -.
DR   PIR; S01030; WJHU3E.
DR   RefSeq; NP_055435.2; NM_014620.5.
DR   RefSeq; NP_705897.1; NM_153633.2.
DR   SMR; P09017; -.
DR   BioGRID; 109461; 28.
DR   IntAct; P09017; 20.
DR   MINT; P09017; -.
DR   STRING; 9606.ENSP00000399808; -.
DR   iPTMnet; P09017; -.
DR   PhosphoSitePlus; P09017; -.
DR   BioMuta; HOXC4; -.
DR   DMDM; 281185468; -.
DR   MassIVE; P09017; -.
DR   MaxQB; P09017; -.
DR   PaxDb; P09017; -.
DR   PeptideAtlas; P09017; -.
DR   PRIDE; P09017; -.
DR   ProteomicsDB; 52186; -.
DR   Antibodypedia; 27312; 279 antibodies.
DR   DNASU; 3221; -.
DR   Ensembl; ENST00000303406; ENSP00000305973; ENSG00000198353.
DR   Ensembl; ENST00000430889; ENSP00000399808; ENSG00000198353.
DR   GeneID; 3221; -.
DR   KEGG; hsa:3221; -.
DR   UCSC; uc001seu.5; human.
DR   CTD; 3221; -.
DR   DisGeNET; 3221; -.
DR   EuPathDB; HostDB:ENSG00000198353.7; -.
DR   GeneCards; HOXC4; -.
DR   HGNC; HGNC:5126; HOXC4.
DR   HPA; ENSG00000198353; Tissue enhanced (brain, ovary).
DR   MIM; 142974; gene.
DR   neXtProt; NX_P09017; -.
DR   OpenTargets; ENSG00000198353; -.
DR   PharmGKB; PA29401; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000160794; -.
DR   HOGENOM; CLU_061398_0_0_1; -.
DR   InParanoid; P09017; -.
DR   OMA; AYNGTEP; -.
DR   OrthoDB; 1154159at2759; -.
DR   PhylomeDB; P09017; -.
DR   TreeFam; TF352857; -.
DR   PathwayCommons; P09017; -.
DR   Reactome; R-HSA-5617472; Activation of anterior HOX genes in hindbrain development during early embryogenesis.
DR   SIGNOR; P09017; -.
DR   BioGRID-ORCS; 3221; 14 hits in 862 CRISPR screens.
DR   ChiTaRS; HOXC4; human.
DR   GeneWiki; HOXC4; -.
DR   GenomeRNAi; 3221; -.
DR   Pharos; P09017; Tbio.
DR   PRO; PR:P09017; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; P09017; protein.
DR   Bgee; ENSG00000198353; Expressed in right uterine tube and 214 other tissues.
DR   ExpressionAtlas; P09017; baseline and differential.
DR   Genevisible; P09017; HS.
DR   GO; GO:0000790; C:nuclear chromatin; ISA:NTNU_SB.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0033613; F:activating transcription factor binding; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0071837; F:HMG box domain binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR   GO; GO:0001501; P:skeletal system development; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Polymorphism;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..264
FT                   /note="Homeobox protein Hox-C4"
FT                   /id="PRO_0000200164"
FT   DNA_BIND        156..215
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   MOTIF           135..140
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        54..60
FT                   /note="Poly-Pro"
FT   COMPBIAS        183..186
FT                   /note="Poly-Arg"
FT   VARIANT         158
FT                   /note="R -> L (in dbSNP:rs11835301)"
FT                   /id="VAR_055961"
FT   VARIANT         178
FT                   /note="N -> S (in dbSNP:rs35406888)"
FT                   /id="VAR_055962"
FT   CONFLICT        161
FT                   /note="T -> A (in Ref. 1; CAA30376 and 2; AAG42145)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   264 AA;  29811 MW;  5CCD13995574226E CRC64;
     MIMSSYLMDS NYIDPKFPPC EEYSQNSYIP EHSPEYYGRT RESGFQHHHQ ELYPPPPPRP
     SYPERQYSCT SLQGPGNSRG HGPAQAGHHH PEKSQSLCEP APLSGASASP SPAPPACSQP
     APDHPSSAAS KQPIVYPWMK KIHVSTVNPN YNGGEPKRSR TAYTRQQVLE LEKEFHYNRY
     LTRRRRIEIA HSLCLSERQI KIWFQNRRMK WKKDHRLPNT KVRSAPPAGA APSTLSAATP
     GTSEDHSQSA TPPEQQRAED ITRL
//