ID CD63_HUMAN STANDARD; PRT; 237 AA. AC P08962; DT 01-NOV-1988 (REL. 09, CREATED) DT 01-NOV-1988 (REL. 09, LAST SEQUENCE UPDATE) DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE) DE CD63 ANTIGEN (MELANOMA-ASSOCIATED ANTIGEN ME491) (LYSOSOME-ASSOCIATED DE MEMBRANE GLYCOPROTEIN 3) (LAMP-3). GN MLA1. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RM 88210273 RA HOTTA H., ROSS A.H., HUEBNER K., ISOBE M., WENDEBORN S., CHAO M.V., RA RICCIARDI R.P., TSUJIMOTO Y., CROCE C.M., KOPROWSKI H.; RL CANCER RES. 48:2955-2962(1988). RN [2] RP SEQUENCE FROM N.A. RM 91131632 RA METZELAAR M.J., WIGNGAARD P.L., PETERS P.J., SIXMA J.J., RA NIEUWENHUIS H.K., CLEVERS H.C.; RL J. BIOL. CHEM. 266:3239-3245(1991). RN [3] RP SEQUENCE OF 1-20. RM 86049405 RA ROSS A.H., DIETZSCHOLD B., JACKSON D.M., EARLEY J.J., GHRIST B.F.D., RA ATKINSON B., KOPROWSKI H.; RL ARCH. BIOCHEM. BIOPHYS. 242:540-548(1985). CC -!- FUNCTION: THIS ANTIGEN IS ASSOCIATED WITH EARLY STAGES OF MELANOMA CC TUMOR PROGRESSION. CC -!- SUBCELLULAR LOCATION: TYPE II MEMBRANE PROTEIN. TYPE II PROTEINS CC CONTAIN A N-TERMINAL MEMBRANE-ANCHORING DOMAIN WHICH IS NOT CC CLEAVED DURING BIOSYNTHESIS AND WHICH FUNCTION BOTH AS A CC TRANSLOCATION SIGNAL AND AS A MEMBRANE ANCHOR. CC -!- SUBCELLULAR LOCATION: LYSOSOMAL MEMBRANE. CC -!- TISSUE SPECIFICITY: DYSPLASTIC NEVI, RADIAL GROWTH PHASE PRIMARY CC MELANOMAS, HEMATOPOIETIC CELLS, TISSUE MACROPHAGES. CC -!- SIMILARITY: BELONGS TO A FAMILY THAT GROUPS TOGETHER: CD9, CD37, CC CD53, CD63, TAPA-1, CO-029, AND S.MANSONI SM23. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X07982; HSME491. DR EMBL; M58485; HSCD63. DR PIR; S01418; S01418. DR PIR; A39514; A39514. DR MIM; 155740; NINTH EDITION. DR PROSITE; PS00421; TYPE2_MEMBRAN_ANTIGEN. KW GLYCOPROTEIN; ANTIGEN; TRANSMEMBRANE; SIGNAL-ANCHOR; LYSOSOME. FT INIT_MET 0 0 FT DOMAIN 1 10 CYTOPLASMIC (PROBABLE). FT TRANSMEM 11 34 SIGNAL-ANCHOR (TYPE-II MEMBRANE PROTEIN). FT DOMAIN 35 50 EXTRACELLULAR (PROBABLE). FT TRANSMEM 51 69 POTENTIAL. FT DOMAIN 70 80 CYTOPLASMIC (PROBABLE). FT TRANSMEM 81 106 POTENTIAL. FT DOMAIN 107 202 EXTRACELLULAR (PROBABLE). FT TRANSMEM 203 223 POTENTIAL. FT DOMAIN 224 237 CYTOPLASMIC (PROBABLE). FT CARBOHYD 129 129 POTENTIAL. FT CARBOHYD 149 149 POTENTIAL. FT CARBOHYD 171 171 POTENTIAL. SQ SEQUENCE 237 AA; 25505 MW; 283175 CN; AVEGGMKCVK FLLYVLLLAF CACAVGLIAV GVGAQLVLSQ TIIQGATPGS LLPVVIIAVG VFLFLVAFVG CCGACKENYC LMITFAIFLS LIMLVEVAAA IAGYVFRDKV MSEFNNNFRQ QMENYPKNNH TASILDRMQA DFKCCGAANY TDWEKIPSMS KNRVPDSCCI NVTVGCGINF NEKAIHKEGC VEKIGGWLRK NVLVVAAAAL GIAFVEVLGI VFACCLVKSI RSGYEVM //