ID ME49$HUMAN STANDARD; PRT; 237 AA. AC P08962; DT 01-NOV-1988 (REL. 09, CREATED) DT 01-NOV-1988 (REL. 09, LAST SEQUENCE UPDATE) DT 01-NOV-1990 (REL. 16, LAST ANNOTATION UPDATE) DE MELANOMA-ASSOCIATED ANTIGEN ME491 (GENE NAME: MLA1). OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RC MEDLINE=88210273; RA HOTTA H., ROSS A.H., HUEBNER K., ISOBE M., WENDEBORN S., CHAO M.V., RA RICCIARDI R.P., TSUJIMOTO Y., CROCE C.M., KOPROWSKI H.; RL CANCER RES. 48:2955-2962(1988). RN [2] RP SEQUENCE OF 1-20. RC MEDLINE=86049405; RA ROSS A.H., DIETZSCHOLD B., JACKSON D.M., EARLEY J.J., GHRIST B.F.D., RA ATKINSON B., KOPROWSKI H.; RL ARCH. BIOCHEM. BIOPHYS. 242:540-548(1985). CC -!- FUNCTION: THIS ANTIGEN IS ASSOCIATED WITH EARLY STAGES OF MELANOMA CC TUMOR PROGRESSION. CC -!- SUBCELLULAR LOCATION: TYPE II MEMBRANE PROTEIN. TYPE II PROTEINS CC CONTAIN A N-TERMINAL MEMBRANE-ANCHORING DOMAIN WHICH IS NOT CC CLEAVED DURING BIOSYNTHESIS AND WHICH FUNCTION BOTH AS A CC TRANSLOCATION SIGNAL AND AS A MEMBRANE ANCHOR. CC -!- SIMILARITY: BELONGS TO A FAMILY THAT GROUPS TOGETHER: CD37, CD53, CC ME491, TAPA-1, CO-029, AND S.MANSONI SM23. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X07982; HSME491. DR PIR; S01418; S01418. DR MIM; 155740; NINTH EDITION. DR PROSITE; PS00421; TYPE2_MEMBRAN_ANTIGEN. KW GLYCOPROTEIN; ANTIGEN; TRANSMEMBRANE; SIGNAL-ANCHOR. FT INIT_MET 0 0 FT DOMAIN 1 10 CYTOPLASMIC (PROBABLE). FT TRANSMEM 11 34 SIGNAL-ANCHOR (TYPE-II MEMBRANE PROTEIN). FT DOMAIN 35 50 EXTRACELLULAR (PROBABLE). FT TRANSMEM 51 69 PUTATIVE. FT DOMAIN 70 80 CYTOPLASMIC (PROBABLE). FT TRANSMEM 81 106 PUTATIVE. FT DOMAIN 107 202 EXTRACELLULAR (PROBABLE). FT TRANSMEM 203 223 PUTATIVE. FT DOMAIN 224 237 CYTOPLASMIC (PROBABLE). FT CARBOHYD 129 129 POTENTIAL. FT CARBOHYD 149 149 POTENTIAL. FT CARBOHYD 171 171 POTENTIAL. SQ SEQUENCE 237 AA; 25505 MW; 283175 CN; AVEGGMKCVK FLLYVLLLAF CACAVGLIAV GVGAQLVLSQ TIIQGATPGS LLPVVIIAVG VFLFLVAFVG CCGACKENYC LMITFAIFLS LIMLVEVAAA IAGYVFRDKV MSEFNNNFRQ QMENYPKNNH TASILDRMQA DFKCCGAANY TDWEKIPSMS KNRVPDSCCI NVTVGCGINF NEKAIHKEGC VEKIGGWLRK NVLVVAAAAL GIAFVEVLGI VFACCLVKSI RSGYEVM //