ID ME49$HUMAN STANDARD; PRT; 237 AA. AC P08962; DT 01-NOV-1988 (REL. 09, CREATED) DT 01-NOV-1988 (REL. 09, LAST SEQUENCE UPDATE) DT 01-MAR-1989 (REL. 10, LAST ANNOTATION UPDATE) DE MELANOMA-ASSOCIATED ANTIGEN ME491. OS HUMAN (HOMO SAPIENS). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] (SEQUENCE FROM N.A.) RA HOTTA H., ROSS A.H., HUEBNER K., ISOBE M., WENDEBORN S., CHAO M.V., RA RICCIARDI R.P., TSUJIMOTO Y., CROCE C.M., KOPROWSKI H.; RL CANCER RES. 48:2955-2962(1988). RN [2] (SEQUENCE OF 1-20) RA ROSS A.H., DIETZSCHOLD B., JACKSON D.M., EARLEY J.J., GHRIST B.F.D., RA ATKINSON B., KOPROWSKI H.; RL ARCH. BIOCHEM. BIOPHYS. 242:540-548(1985). CC -!- FUNCTION: THIS ANTIGEN IS ASSOCIATED WITH EARLY STAGES OF MELANOMA CC TUMOR PROGRESSION. CC -!- SUBCELLULAR LOCATION: PLASMA MEMBRANE. CC -!- SIMILARITY: NO SIGNIFICANT SIMILARITY WITH KNOWN PROTEINS. CC -!- HYDROPHOBICITY PLOT ANALYSIS SUGGESTS 3 CONSECUTIVE TRANSMEMBRANE CC REGIONS NEAR THE N-TERMINUS AND A 4TH ONE NEAR THE C-TERMINUS. CC THE 3 POT. N-GLYCOSYLATION SITES ARE LOCATED BETWEEN THE TRANS- CC MEMBRANE DOMAINS III AND IV AND ARE THOUGHT TO BE LOCATED ON THE CC EXTRACELLULAR SURFACE, WHILE THE N-TERMINUS LIES INSIDE THE CC CYTOPLASM. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X07982; HSME491. KW GLYCOPROTEIN; ANTIGEN; TRANSMEMBRANE. FT INIT_MET 0 0 FT CARBOHYD 129 129 POTENTIAL. FT CARBOHYD 149 149 POTENTIAL. FT CARBOHYD 171 171 POTENTIAL. SQ SEQUENCE 237 AA; 25505 MW; 283175 CN; AVEGGMKCVK FLLYVLLLAF CACAVGLIAV GVGAQLVLSQ TIIQGATPGS LLPVVIIAVG VFLFLVAFVG CCGACKENYC LMITFAIFLS LIMLVEVAAA IAGYVFRDKV MSEFNNNFRQ QMENYPKNNH TASILDRMQA DFKCCGAANY TDWEKIPSMS KNRVPDSCCI NVTVGCGINF NEKAIHKEGC VEKIGGWLRK NVLVVAAAAL GIAFVEVLGI VFACCLVKSI RSGYEVM //