ID CD63_HUMAN STANDARD; PRT; 237 AA. AC P08962; DT 01-NOV-1988 (REL. 09, CREATED) DT 01-NOV-1988 (REL. 09, LAST SEQUENCE UPDATE) DT 01-FEB-1996 (REL. 33, LAST ANNOTATION UPDATE) DE CD63 ANTIGEN (MELANOMA-ASSOCIATED ANTIGEN ME491) (LYSOSOME-ASSOCIATED DE MEMBRANE GLYCOPROTEIN 3) (LAMP-3) (OCULAR MELANOMA-ASSOCIATED DE ANTIGEN) (OMA81H). GN CD63 OR MLA1. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 88210273. RA HOTTA H., ROSS A.H., HUEBNER K., ISOBE M., WENDEBORN S., CHAO M.V., RA RICCIARDI R.P., TSUJIMOTO Y., CROCE C.M., KOPROWSKI H.; RL CANCER RES. 48:2955-2962(1988). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 91131632. RA METZELAAR M.J., WIGNGAARD P.L., PETERS P.J., SIXMA J.J., RA NIEUWENHUIS H.K., CLEVERS H.C.; RL J. BIOL. CHEM. 266:3239-3245(1991). RN [3] RP SEQUENCE FROM N.A. RC TISSUE=OVARY; RX MEDLINE; 91025550. RA RAPP G., FREUDENSTEIN J., KLAUDINY J., MUCHA J., WEMPE F., ZIMMER M., RA SCHEIT K.H.; RL DNA CELL BIOL. 9:479-485(1990). RN [4] RP SEQUENCE FROM N.A. RX MEDLINE; 92287132. RA HOTTA H., MIYAMOTO H., HARA I., TAKAHASHI N., HOMMA M.; RL BIOCHEM. BIOPHYS. RES. COMMUN. 185:436-442(1992). RN [5] RP SEQUENCE FROM N.A. RX MEDLINE; 92181348. RA WANG M.X., EARLEY J.J. JR., SHIELDS J.A., DONOSO L.A.; RL ARCH. OPHTHALMOL. 110:399-404(1992). RN [6] RP SEQUENCE OF 1-20. RX MEDLINE; 86049405. RA ROSS A.H., DIETZSCHOLD B., JACKSON D.M., EARLEY J.J., GHRIST B.F.D., RA ATKINSON B., KOPROWSKI H.; RL ARCH. BIOCHEM. BIOPHYS. 242:540-548(1985). CC -!- FUNCTION: THIS ANTIGEN IS ASSOCIATED WITH EARLY STAGES OF MELANOMA CC TUMOR PROGRESSION. MAY PLAY A ROLE IN GROWTH REGULATION. CC -!- SUBCELLULAR LOCATION: TYPE II MEMBRANE PROTEIN. LYSOSOMAL. CC -!- TISSUE SPECIFICITY: DYSPLASTIC NEVI, RADIAL GROWTH PHASE PRIMARY CC MELANOMAS, HEMATOPOIETIC CELLS, TISSUE MACROPHAGES. CC -!- SIMILARITY: BELONGS TO THE FAMILY OF SMALL TYPE-II MEMBRANE CC ANTIGENS (TM4 SUPERFAMILY). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X07982; G34527; -. DR EMBL; M58485; -; NOT_ANNOTATED_CDS. DR EMBL; M59907; G189384; -. DR EMBL; X62654; G430756; -. DR EMBL; S93788; G246539; -. DR PIR; S01418; S01418. DR PIR; A39514; A39514. DR PIR; B35826; B35826. DR MIM; 155740; -. DR PROSITE; PS00421; TM4. KW GLYCOPROTEIN; ANTIGEN; TRANSMEMBRANE; SIGNAL-ANCHOR; LYSOSOME. FT INIT_MET 0 0 FT DOMAIN 1 10 CYTOPLASMIC (PROBABLE). FT TRANSMEM 11 34 SIGNAL-ANCHOR (TYPE-II MEMBRANE PROTEIN). FT DOMAIN 35 50 EXTRACELLULAR (PROBABLE). FT TRANSMEM 51 69 POTENTIAL. FT DOMAIN 70 80 CYTOPLASMIC (PROBABLE). FT TRANSMEM 81 106 POTENTIAL. FT DOMAIN 107 202 EXTRACELLULAR (PROBABLE). FT TRANSMEM 203 223 POTENTIAL. FT DOMAIN 224 237 CYTOPLASMIC (PROBABLE). FT CARBOHYD 129 129 POTENTIAL. FT CARBOHYD 149 149 POTENTIAL. FT CARBOHYD 171 171 POTENTIAL. SQ SEQUENCE 237 AA; 25505 MW; 0005E0B5 CRC32; AVEGGMKCVK FLLYVLLLAF CACAVGLIAV GVGAQLVLSQ TIIQGATPGS LLPVVIIAVG VFLFLVAFVG CCGACKENYC LMITFAIFLS LIMLVEVAAA IAGYVFRDKV MSEFNNNFRQ QMENYPKNNH TASILDRMQA DFKCCGAANY TDWEKIPSMS KNRVPDSCCI NVTVGCGINF NEKAIHKEGC VEKIGGWLRK NVLVVAAAAL GIAFVEVLGI VFACCLVKSI RSGYEVM //