ID 5HT1A_HUMAN STANDARD; PRT; 422 AA. AC P08908; Q6LAE7; DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1993, sequence version 3. DT 03-OCT-2006, entry version 71. DE 5-hydroxytryptamine 1A receptor (5-HT-1A) (Serotonin receptor 1A) (5- DE HT1A) (G-21). GN Name=HTR1A; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=87315369; PubMed=3041227; DOI=10.1038/329075a0; RA Kobilka B.K., Frielle T., Collins S., Yang-Feng T.L., Kobilka T.S., RA Francke U., Lefkowitz R.J., Caron M.G.; RT "An intronless gene encoding a potential member of the family of RT receptors coupled to guanine nucleotide regulatory proteins."; RL Nature 329:75-79(1987). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Saltzman A.G., Morse B., Felder S.; RL Submitted (FEB-1991) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Kitano T., Kobayakawa H., Saitou N.; RT "Silver project."; RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP NUCLEOTIDE SEQUENCE OF 1-9. RX MEDLINE=92115564; PubMed=1766875; RA Parks C.L., Chang L.S., Shenk T.; RT "A polymerase chain reaction mediated by a single primer: cloning of RT genomic sequences adjacent to a serotonin receptor protein coding RT region."; RL Nucleic Acids Res. 19:7155-7160(1991). RN [7] RP NUCLEOTIDE SEQUENCE OF 200-365. RX MEDLINE=93329096; PubMed=8393041; RA Aune T.M., McGrath K.M., Sarr T., Bombara M.P., Kelley K.A.; RT "Expression of 5HT1a receptors on activated human T cells. Regulation RT of cyclic AMP levels and T cell proliferation by 5- RT hydroxytryptamine."; RL J. Immunol. 151:1175-1183(1993). RN [8] RP FUNCTION. RX MEDLINE=88334700; PubMed=3138543; DOI=10.1038/335358a0; RA Fargin A., Raymond J.R., Lohse M.L., Kobilka B.K., Caron M.G., RA Lefkowitz R.J.; RT "The genomic clone G-21 which resembles a beta-adrenergic receptor RT sequence encodes the 5-HT1A receptor."; RL Nature 335:358-360(1988). RN [9] RP VARIANTS SER-22 AND VAL-28. RX MEDLINE=95275307; PubMed=7755630; RA Nakhai B., Nielsen D.A., Linnoila M., Goldman D.; RT "Two naturally occurring amino acid substitutions in the human 5-HT1A RT receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28."; RL Biochem. Biophys. Res. Commun. 210:530-536(1995). RN [10] RP VARIANTS LEU-16 AND ASP-273. RX MEDLINE=98425601; PubMed=9754630; RX DOI=10.1002/(SICI)1096-8628(19980907)81:5<434::AID-AJMG13>3.0.CO;2-D; RA Kawanishi Y., Harada S., Tachikawa H., Okubo T., Shiraishi H.; RT "Novel mutations in the promoter and coding region of the human 5-HT1A RT receptor gene and association analysis in schizophrenia."; RL Am. J. Med. Genet. 81:434-439(1998). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions CC as a neurotransmitter, a hormone, and a mitogen. The activity of CC this receptor is mediated by G proteins that inhibit adenylate CC cyclase activity. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M28269; AAA36440.1; -; Genomic_DNA. DR EMBL; X13556; CAA31908.1; -; Genomic_DNA. DR EMBL; X57829; CAA40962.1; -; Genomic_DNA. DR EMBL; M83181; AAA66493.1; -; Genomic_DNA. DR EMBL; AB041403; BAA94488.1; -; Genomic_DNA. DR EMBL; BC069159; AAH69159.1; -; mRNA. DR EMBL; AF498978; AAM21125.1; -; mRNA. DR EMBL; Z11168; CAA77560.1; -; Genomic_DNA. DR PIR; I38209; I38209. DR UniGene; Hs.247940; -. DR HSSP; P08913; 1HLL. DR Ensembl; ENSG00000178394; Homo sapiens. DR KEGG; hsa:3350; -. DR HGNC; HGNC:5286; HTR1A. DR MIM; 109760; gene. DR ArrayExpress; P08908; -. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0004993; F:serotonin receptor activity; TAS. DR GO; GO:0007610; P:behavior; TAS. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS. DR GO; GO:0008284; P:positive regulation of cell proliferation; TAS. DR InterPro; IPR000610; 5HT1A_rcpt. DR InterPro; IPR002231; 5HT_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00512; 5HT1ARECEPTR. DR PRINTS; PR01101; 5HTRECEPTOR. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 422 5-hydroxytryptamine 1A receptor. FT /FTId=PRO_0000068903. FT TOPO_DOM 1 36 Extracellular (Potential). FT TRANSMEM 37 62 1 (Potential). FT TOPO_DOM 63 73 Cytoplasmic (Potential). FT TRANSMEM 74 98 2 (Potential). FT TOPO_DOM 99 109 Extracellular (Potential). FT TRANSMEM 110 132 3 (Potential). FT TOPO_DOM 133 152 Cytoplasmic (Potential). FT TRANSMEM 153 178 4 (Potential). FT TOPO_DOM 179 191 Extracellular (Potential). FT TRANSMEM 192 217 5 (Potential). FT TOPO_DOM 218 345 Cytoplasmic (Potential). FT TRANSMEM 346 367 6 (Potential). FT TOPO_DOM 368 378 Extracellular (Potential). FT TRANSMEM 379 403 7 (Potential). FT TOPO_DOM 404 422 Cytoplasmic (Potential). FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential). FT CARBOHYD 11 11 N-linked (GlcNAc...) (Potential). FT CARBOHYD 24 24 N-linked (GlcNAc...) (Potential). FT DISULFID 109 187 By similarity. FT VARIANT 16 16 P -> L (in dbSNP:1800041). FT /FTId=VAR_003446. FT VARIANT 22 22 G -> S (in dbSNP:1799920). FT /FTId=VAR_011826. FT VARIANT 28 28 I -> V (in dbSNP:1799921). FT /FTId=VAR_011827. FT VARIANT 184 184 P -> L (in dbSNP:1800043). FT /FTId=VAR_011828. FT VARIANT 220 220 R -> L (in dbSNP:1800044). FT /FTId=VAR_011829. FT VARIANT 273 273 G -> D (in dbSNP:1800042). FT /FTId=VAR_011830. FT CONFLICT 152 154 RAA -> PR (in Ref. 1). FT CONFLICT 172 172 M -> I (in Ref. 1). FT CONFLICT 200 202 TFG -> RPR (in Ref. 7). FT CONFLICT 228 228 K -> R (in Ref. 7). FT CONFLICT 244 244 A -> AA (in Ref. 7). FT CONFLICT 355 355 I -> T (in Ref. 7). FT CONFLICT 363 365 IVA -> MRP (in Ref. 7). FT CONFLICT 418 418 K -> N (in Ref. 1). SQ SEQUENCE 422 AA; 46107 MW; 762664FCF62CFD8F CRC64; MDVLSPGQGN NTTSPPAPFE TGGNTTGISD VTVSYQVITS LLLGTLIFCA VLGNACVVAA IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN KWTLGQVTCD LFIALDVLCC TSSILHLCAI ALDRYWAITD PIDYVNKRTP RRAAALISLT WLIGFLISIP PMLGWRTPED RSDPDACTIS KDHGYTIYST FGAFYIPLLL MLVLYGRIFR AARFRIRKTV KKVEKTGADT RHGASPAPQP KKSVNGESGS RNWRLGVESK AGGALCANGA VRQGDDGAAL EVIEVHRVGN SKEHLPLPSE AGPTPCAPAS FERKNERNAE AKRKMALARE RKTVKTLGII MGTFILCWLP FFIVALVLPF CESSCHMPTL LGAIINWLGY SNSLLNPVIY AYFNKDFQNA FKKIIKCKFC RQ //