ID CISZ_YEAST STANDARD; PRT; 460 AA. AC P08679; DT 01-JAN-1988 (REL. 06, CREATED) DT 01-JAN-1988 (REL. 06, LAST SEQUENCE UPDATE) DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE) DE CITRATE SYNTHASE, CYTOPLASMIC (EC 4.1.3.7). GN CIT2 OR YCR043 OR YCR5C. OS SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). OC EUKARYOTA; FUNGI; ASCOMYCOTINA; HEMIASCOMYCETES. RN [1] RP SEQUENCE FROM N.A. RA BITEAU N., FREMAUX C., HEBRARD S., MENARA A., AIGLE M., CROUZET M.; RL YEAST 8:61-70(1992). RN [2] RP SEQUENCE FROM N.A. RM 87089811 RA ROSENKRANTZ M., ALAM T., KIM K.-S., CLARK B.J., SRERE P.A., RA GUARENTE L.P.; RL MOL. CELL. BIOL. 6:4509-4515(1986). RN [3] RP SEQUENCE OF 1-24 FROM N.A. RM 91094853 RA LIAO X., SMALL W.C., SRERE P.A., BUTOW R.A.; RL MOL. CELL. BIOL. 11:38-46(1991). CC -!- CITRATE SYNTHASE IS FOUND IN NEARLY ALL CELLS CAPABLE OF OXIDATIVE CC METABOLISM. CC -!- CATALYTIC ACTIVITY: CITRATE + COA = ACETYL-COA + H(2)O + CC OXALOACETATE. CC -!- PATHWAY: TRICARBOXYLIC ACID CYCLE. CC -!- SUBCELLULAR LOCATION: CYTOPLASMIC. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z11113; SC1. DR EMBL; M14686; SCCIT2. DR EMBL; M54982; SCCIT2A. DR EMBL; X59720; X59720. DR PIR; A25393; A25393. DR PIR; S19474; S19474. KW LYASE; TRICARBOXYLIC ACID CYCLE; MULTIGENE FAMILY. FT PROPEP 1 21 POTENTIAL. FT CHAIN 22 460 CITRATE SYNTHASE. FT ACT_SITE 293 293 BY SIMILARITY. FT ACT_SITE 339 339 BY SIMILARITY. FT ACT_SITE 394 394 BY SIMILARITY. SQ SEQUENCE 460 AA; 51413 MW; 1137104 CN; MTVPYLNSNR NVASYLQSNS SQEKTLKERF SEIYPIHAQD VRQFVKEHGK TKISDVLLEQ VYGGMRGIPG SVWEGSVLDP EDGIRFRGRT IADIQKDLPK AKGSSQPLPE ALFWLLLTGE VPTQAQVENL SADLMSRSEL PSHVVQLLDN LPKDLHPMAQ FSIAVTALES ESKFAKAYAQ GISKQDYWSY TFEDSLDLLG KLPVIAAKIY RNVFKDGKMG EVDPNADYAK NLVNLIGSKD EDFVDLMRLY LTIHSDHEGG NVSAHTSHLV GSALSSPYLS LASGLNGLAG PLHGRANQEV LEWLFALKEE VNDDYSKDTI EKYLWDTLNS GRVIPGYGHA VLRKTDPRYM AQRKFAMDHF PDYELFKLVS SIYEVAPGVL TEHGKTKNPW PNVDAHSGVL LQYYGLKESS FYTVLFGVSR AFGILAQLIT DRAIGASIER PKSYSTEKYK ELVKNIESKL //