ID RAS3_DROME STANDARD; PRT; 184 AA. AC P08645; DT 13-AUG-1987 (REL. 05, CREATED) DT 01-AUG-1992 (REL. 23, LAST SEQUENCE UPDATE) DT 01-JUL-1993 (REL. 26, LAST ANNOTATION UPDATE) DE RAS-LIKE PROTEIN 3 (ROUGHENED PROTEIN). GN R OR RAS3 OR RAS62B OR RAP. OS DROSOPHILA MELANOGASTER (FRUIT FLY). OC EUKARYOTA; METAZOA; ARTHROPODA; INSECTA; DIPTERA. RN [1] RP SEQUENCE FROM N.A. RM 92034992 RA HARIHARAN I.K., CARTHEW R.W., RUBIN G.M.; RL CELL 67:717-722(1991). RN [2] RP SEQUENCE FROM N.A. RM 85257468 RA SCHEJTER E.D., SHILO B.Z.; RL EMBO J. 4:407-412(1985). CC -!- FUNCTION: RAS PROTEINS BIND GDP/GTP AND POSSESS INTRINSIC GTPASE CC ACTIVITY. CC -!- DISEASE: THE ROUGHENED MUTATION DISRUPTS THE EARLY STAGES OF CC PHOTORECEPTOR CELL DETERMINATION. CC -!- SIMILARITY: TO RAS PROTEINS. BELONGS TO THE RAP SUB-FAMILY. CC -!- CAUTION: DUE TO FRAMESHIFT ERRORS REF. 2 WAS INCORRECT IN CC POSITIONS 76-96 AND 160-180. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M80535; DMRAP1A. DR EMBL; X02200; DMRAS3. DR PIR; S07187; TVFFR3. DR PIR; A41217; A41217. DR FLYBASE; 04636; R. KW GTP-BINDING; PRENYLATION; LIPOPROTEIN; VISION. FT CHAIN 1 181 RAS-LIKE PROTEIN 3. FT PROPEP 182 184 REMOVED IN MATURE FORM (BY SIMILARITY). FT NP_BIND 10 17 GTP (BY SIMILARITY). FT NP_BIND 57 61 GTP (BY SIMILARITY). FT NP_BIND 116 119 GTP (BY SIMILARITY). FT DOMAIN 32 40 EFFECTOR REGION (PROBABLE). FT LIPID 181 181 GERANYL-GERANYL (BY SIMILARITY). FT VARIANT 157 157 F -> L (IN ROUGHENED MUTANTS). FT CONFLICT 45 49 EVDGQ -> KVNER (IN REF. 2). FT CONFLICT 56 57 LD -> VN (IN REF. 2). FT CONFLICT 69 69 D -> N (IN REF. 2). SQ SEQUENCE 184 AA; 20863 MW; 175722 CN; MREYKIVVLG SGGVGKSALT VQFVQCIFVE KYDPTIEDSY RKQVEVDGQQ CMLEILDTAG TEQFTAMRDL YMKNGQGFVL VYSITAQSTF NDLQDLREQI LRVKDTDDVP MVLVGNKCDL EEERVVGKEL GKNLATQFNC AFMETSAKAK VNVNDIFYDL VRQINKKSPE KKQKKPKKSL CVLL //