ID TKN_KASSE Reviewed; 12 AA. AC P08611; DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1988, sequence version 1. DT 02-NOV-2016, entry version 68. DE RecName: Full=Kassinin; OS Kassina senegalensis (Senegal running frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Neobatrachia; Microhyloidea; Hyperoliidae; OC Kassina. OX NCBI_TaxID=8415; RN [1] RP PROTEIN SEQUENCE. RC TISSUE=Skin secretion; RX PubMed=891753; DOI=10.1007/BF01951242; RA Anastasi A., Montecucchi P.C., Erspamer V., Visser J.; RT "Amino acid composition and sequence of kassinin, a tachykinin RT dodecapeptide from the skin of the African frog Kassina RT senegalensis."; RL Experientia 33:857-858(1977). CC -!- FUNCTION: Tachykinins are active peptides which excite neurons, CC evoke behavioral responses, are potent vasodilators and CC secretagogues, and contract (directly or indirectly) many smooth CC muscles. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Expressed by the skin glands. CC -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PIR; S07206; S07206. DR PDB; 1MYU; NMR; -; A=1-12. DR PDBsum; 1MYU; -. DR SMR; P08611; -. DR EvolutionaryTrace; P08611; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW. DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW. DR GO; GO:0007217; P:tachykinin receptor signaling pathway; IEA:InterPro. DR InterPro; IPR013055; Tachy_Neuro_lke_CS. DR InterPro; IPR008215; Tachykinin_dom. DR Pfam; PF02202; Tachykinin; 1. DR PROSITE; PS00267; TACHYKININ; 1. PE 1: Evidence at protein level; KW 3D-structure; Amidation; Amphibian defense peptide; KW Direct protein sequencing; Neuropeptide; Secreted. FT PEPTIDE 1 12 Kassinin. FT /FTId=PRO_0000044397. FT MOD_RES 12 12 Methionine amide. FT {ECO:0000269|PubMed:891753}. FT HELIX 4 11 {ECO:0000244|PDB:1MYU}. SQ SEQUENCE 12 AA; 1336 MW; 91757AB89DD6DAB5 CRC64; DVPKSDQFVG LM //