ID   TKN_KASSE               Reviewed;          12 AA.
AC   P08611;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   11-MAY-2016, entry version 66.
DE   RecName: Full=Kassinin;
OS   Kassina senegalensis (Senegal running frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Neobatrachia; Microhyloidea; Hyperoliidae;
OC   Kassina.
OX   NCBI_TaxID=8415;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Skin secretion;
RX   PubMed=891753; DOI=10.1007/BF01951242;
RA   Anastasi A., Montecucchi P.C., Erspamer V., Visser J.;
RT   "Amino acid composition and sequence of kassinin, a tachykinin
RT   dodecapeptide from the skin of the African frog Kassina
RT   senegalensis.";
RL   Experientia 33:857-858(1977).
CC   -!- FUNCTION: Tachykinins are active peptides which excite neurons,
CC       evoke behavioral responses, are potent vasodilators and
CC       secretagogues, and contract (directly or indirectly) many smooth
CC       muscles.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the tachykinin family. {ECO:0000305}.
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DR   PIR; S07206; S07206.
DR   PDB; 1MYU; NMR; -; A=1-12.
DR   PDBsum; 1MYU; -.
DR   EvolutionaryTrace; P08611; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0007268; P:synaptic transmission; IEA:InterPro.
DR   GO; GO:0007217; P:tachykinin receptor signaling pathway; IEA:InterPro.
DR   InterPro; IPR013055; Tachy_Neuro_lke_CS.
DR   InterPro; IPR008215; Tachykinin_dom.
DR   Pfam; PF02202; Tachykinin; 1.
DR   PROSITE; PS00267; TACHYKININ; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Amidation; Amphibian defense peptide;
KW   Direct protein sequencing; Neuropeptide; Secreted.
FT   PEPTIDE       1     12       Kassinin.
FT                                /FTId=PRO_0000044397.
FT   MOD_RES      12     12       Methionine amide.
FT                                {ECO:0000269|PubMed:891753}.
FT   HELIX         4     11       {ECO:0000244|PDB:1MYU}.
SQ   SEQUENCE   12 AA;  1336 MW;  91757AB89DD6DAB5 CRC64;
     DVPKSDQFVG LM
//