ID DPOL_HCMVA Reviewed; 1242 AA. AC P08546; Q7M6M9; DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1995, sequence version 2. DT 25-NOV-2008, entry version 67. DE RecName: Full=DNA polymerase; DE EC=2.7.7.7; GN Name=UL54; Synonyms=HFLF2; OS Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5). OC Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; OC Betaherpesvirinae; Cytomegalovirus. OX NCBI_TaxID=10360; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=87061230; PubMed=3023690; RA Kouzarides T., Bankier A.T., Satchwell S.C., Weston K.M., RA Tomlinson P., Barrell B.G.; RT "Sequence and transcription analysis of the human cytomegalovirus DNA RT polymerase gene."; RL J. Virol. 61:125-133(1987). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=87151139; PubMed=3029980; DOI=10.1016/0042-6822(87)90282-0; RA Kouzarides T., Bankier A.T., Satchwell S.C., Weston K.M., RA Tomlinson P., Barrell B.G.; RT "Large-scale rearrangement of homologous regions in the genomes of RT HCMV and EBV."; RL Virology 157:397-413(1987). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=90269039; PubMed=2161319; RA Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., RA Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., RA Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.; RT "Analysis of the protein-coding content of the sequence of human RT cytomegalovirus strain AD169."; RL Curr. Top. Microbiol. Immunol. 154:125-169(1990). RN [4] RP GENOME REANNOTATION. RX MEDLINE=22421467; PubMed=12533697; DOI=10.1099/vir.0.18606-0; RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., RA Alcendor D.J., McGeoch D.J., Hayward G.S.; RT "The human cytomegalovirus genome revisited: comparison with the RT chimpanzee cytomegalovirus genome."; RL J. Gen. Virol. 84:17-28(2003). RN [5] RP ERRATUM. RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., RA Alcendor D.J., McGeoch D.J., Hayward G.S.; RL J. Gen. Virol. 84:1053-1053(2003). RN [6] RP IDENTIFICATION. RX PubMed=15452216; DOI=10.1128/JVI.78.20.10960-10966.2004; RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., RA Shenk T., Smith R.D., Nelson J.A.; RT "Identification of proteins in human cytomegalovirus (HCMV) particles: RT the HCMV proteome."; RL J. Virol. 78:10960-10966(2004). RN [7] RP ERRATUM. RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., RA Shenk T., Smith R.D., Nelson J.A.; RL J. Virol. 78:13395-13395(2004). CC -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = CC diphosphate + DNA(n+1). CC -!- SUBCELLULAR LOCATION: Virion. Nucleus. CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X17403; CAA35413.1; -; Genomic_DNA. DR EMBL; M17209; AAA46008.1; -; Genomic_DNA. DR EMBL; M14709; AAA45988.1; -; Genomic_DNA. DR EMBL; BK000394; DAA00159.1; -; Genomic_DNA. DR PIR; S09817; DJBEC1. DR RefSeq; NP_039988.1; -. DR PDB; 1YYP; X-ray; 2.50 A; B=1221-1242. DR PDBsum; 1YYP; -. DR GeneID; 1487749; -. DR DrugBank; DB00369; Cidofovir. DR DrugBank; DB00529; Foscarnet. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW. DR GO; GO:0019012; C:virion; IEA:UniProtKB-KW. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro. DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro. DR GO; GO:0006260; P:DNA replication; IEA:InterPro. DR InterPro; IPR006172; DNA-dir_DNA_pol_B. DR InterPro; IPR006134; DNA-dir_DNA_pol_B_cons-reg. DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc. DR PANTHER; PTHR10322; DNA_pol_B; 1. DR Pfam; PF00136; DNA_pol_B; 1. DR Pfam; PF03104; DNA_pol_B_exo; 1. DR PRINTS; PR00106; DNAPOLB. DR SMART; SM00486; POLBc; 1. DR PROSITE; PS00116; DNA_POLYMERASE_B; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; DNA replication; DNA-binding; KW DNA-directed DNA polymerase; Nucleotidyltransferase; Nucleus; KW Transferase; Virion. FT CHAIN 1 1242 DNA polymerase. FT /FTId=PRO_0000046507. FT CONFLICT 942 943 FV -> VF (in Ref. 3). FT HELIX 1229 1234 FT STRAND 1235 1237 FT HELIX 1238 1240 SQ SEQUENCE 1242 AA; 137102 MW; FA59BFF842BED80B CRC64; MFFNPYLSGG VTGGAVAGGR RQRSQPGSAQ GSGKRPPQKQ FLQIVPRGVM FDGQTGLIKH KTGRLPLMFY REIKHLLSHD MVWPCPWRET LVGRVVGPIR FHTYDQTDAV LFFDSPENVS PRYRQHLVPS GNVLRFFGAT EHGYSICVNV FGQRSYFYCE YSDTDRLREV IASVGELVPE PRTPYAVSVT PATKTSIYGY GTRPVPDLQC VSISNWTMAR KIGEYLLEQG FPVYEVRVDP LTRLVIDRRI TTFGWCSVNR YDWRQQGRAS TCDIEVDCDV SDLVAVPDDS SWPRYRCLSF DIECMSGEGG FPCAEKSDDI VIQISCVCYE TGGNTAVDQG IPNGNDGRGC TSEGVIFGHS GLHLFTIGTC GQVGPDVDVY EFPSEYELLL GFMLFFQRYA PAFVTGYNIN SFDLKYILTR LEYLYKVDSQ RFCKLPTAQG GRFFLHSPAV GFKRQYAAAF PSASHNNPAS TAATKVYIAG SVVIDMYPVC MAKTNSPNYK LNTMAELYLR QRKDDLSYKD IPRCFVANAE GRAQVGRYCL QDAVLVRDLF NTINFHYEAG AIARLAKIPL RRVIFDGQQI RIYTSLLDEC ACRDFILPNH YSKGTTVPET NSVAVSPNAA IISTAAVPGD AGSVAAMFQM SPPLQSAPSS QDGVSPGSGS NSSSSVGVFS VGSGSSGGVG VSNDNHGAGG TAAVSYQGAT VFEPEVGYYN DPVAVFDFAS LYPSIIMAHN LCYSTLLVPG GEYPVDPADV YSVTLENGVT HRFVRASVRV SVLSELLNKW VSQRRAVREC MRECQDPVRR MLLDKEQMAL KVTCNAFYGF TGVVNGMMPC LPIAASITRI GRDMLERTAR FIKDNFSEPC FLHNFFNQED YVVGTREGDS EESSALPEGL ETSSGGSNER RVEARVIYGD TDSVFVRFRG LTPQALVARG PSLAHYVTAC LFVEPVKLEF EKVFVSLMMI CKKRYIGKVE GASGLSMKGV DLVRKTACEF VKGVTRDVLS LLFEDREVSE AAVRLSRLSL DEVKKYGVPR GFWRILRRLV QARDDLYLHR VRVEDLVLSS VLSKDISLYR QSNLPHIAVI KRLAARSEEL PSVGDRVFYV LTAPGVRTAP QGSSDNGDSV TAGVVSRSDA IDGTDDDADG GGVEESNRRG GEPAKKRARK PPSAVCNYEV AEDPSYVREH GVPIHADKYF EQVLKAVTNV LSPVFPGGET ARKDKFLHMV LPRRLHLEPA FLPYSVKAHE CC //