ID DPOL_HCMVA STANDARD; PRT; 1242 AA. AC P08546; DT 01-AUG-1988 (Rel. 08, Created) DT 01-NOV-1995 (Rel. 32, Last sequence update) DT 15-DEC-1998 (Rel. 37, Last annotation update) DE DNA POLYMERASE (EC 2.7.7.7). GN UL54 OR HFLF2. OS Human cytomegalovirus (strain AD169). OC Viruses; dsDNA viruses, no RNA stage; Herpesviridae; OC Betaherpesvirinae; Cytomegalovirus. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 87061230. RA KOUZARIDES T., BANKIER A.T., SATCHWELL S.C., WESTON K., TOMLINSON P., RA BARRELL B.G.; RT "Sequence and transcription analysis of the human cytomegalovirus DNA RT polymerase gene."; RL J. Virol. 61:125-133(1987). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 87151139. RA KOUZARIDES T., BANKIER A.T., SATCHWELL S.C., WESTON K., RA TOMLINSON P., BARRELL B.G.; RT "Large-scale rearrangement of homologous regions in the genomes of RT HCMV and EBV."; RL Virology 157:397-413(1987). RN [3] RP COMPLETE GENOME. RX MEDLINE; 90269039. RA CHEE M.S., BANKIER A.T., BECK S., BOHNI R., BROWN C.M., CERNY R., RA HORSNELL T., HUTCHISON C.A. III, KOUZARIDES T., MARTIGNETTI J.A., RA PREDDIE E., SATCHWELL S.C., TOMLINSON P., WESTON K.M., BARRELL B.G.; RT "Analysis of the protein-coding content of the sequence of human RT cytomegalovirus strain AD169."; RL Curr. Top. Microbiol. Immunol. 154:125-169(1990). CC -!- CATALYTIC ACTIVITY: N DEOXYNUCLEOSIDE TRIPHOSPHATE = CC N PYROPHOSPHATE + DNA(N). CC -!- SUBCELLULAR LOCATION: NUCLEAR. CC -!- SIMILARITY: BELONGS TO DNA POLYMERASE TYPE-B FAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X17403; CAA35413.1; -. DR EMBL; M17209; AAA46008.1; -. DR EMBL; M14709; AAA45988.1; -. DR PIR; S09817; DJBEC1. DR PFAM; PF00136; DNA_pol_B; 1. DR PROSITE; PS00116; DNA_POLYMERASE_B; 1. KW Transferase; DNA-directed DNA polymerase; DNA replication; KW DNA-binding; Nuclear protein. FT CONFLICT 942 943 FV -> VF (IN REF. 3). SQ SEQUENCE 1242 AA; 137101 MW; D831BD75 CRC32; MFFNPYLSGG VTGGAVAGGR RQRSQPGSAQ GSGKRPPQKQ FLQIVPRGVM FDGQTGLIKH KTGRLPLMFY REIKHLLSHD MVWPCPWRET LVGRVVGPIR FHTYDQTDAV LFFDSPENVS PRYRQHLVPS GNVLRFFGAT EHGYSICVNV FGQRSYFYCE YSDTDRLREV IASVGELVPE PRTPYAVSVT PATKTSIYGY GTRPVPDLQC VSISNWTMAR KIGEYLLEQG FPVYEVRVDP LTRLVIDRRI TTFGWCSVNR YDWRQQGRAS TCDIEVDCDV SDLVAVPDDS SWPRYRCLSF DIECMSGEGG FPCAEKSDDI VIQISCVCYE TGGNTAVDQG IPNGNDGRGC TSEGVIFGHS GLHLFTIGTC GQVGPDVDVY EFPSEYELLL GFMLFFQRYA PAFVTGYNIN SFDLKYILTR LEYLYKVDSQ RFCKLPTAQG GRFFLHSPAV GFKRQYAAAF PSASHNNPAS TAATKVYIAG SVVIDMYPVC MAKTNSPNYK LNTMAELYLR QRKDDLSYKD IPRCFVANAE GRAQVGRYCL QDAVLVRDLF NTINFHYEAG AIARLAKIPL RRVIFDGQQI RIYTSLLDEC ACRDFILPNH YSKGTTVPET NSVAVSPNAA IISTAAVPGD AGSVAAMFQM SPPLQSAPSS QDGVSPGSGS NSSSSVGVFS VGSGSSGGVG VSNDNHGAGG TAAVSYQGAT VFEPEVGYYN DPVAVFDFAS LYPSIIMAHN LCYSTLLVPG GEYPVDPADV YSVTLENGVT HRFVRASVRV SVLSELLNKW VSQRRAVREC MRECQDPVRR MLLDKEQMAL KVTCNAFYGF TGVVNGMMPC LPIAASITRI GRDMLERTAR FIKDNFSEPC FLHNFFNQED YVVGTREGDS EESSALPEGL ETSSGGSNER RVEARVIYGD TDSVFVRFRG LTPQALVARG PSLAHYVTAC LFVEPVKLEF EKVFVSLMMI CKKRYIGKVE GASGLSMKGV DLVRKTACEF VKGVTRDVLS LLFEDREVSE AAVRLSRLSL DEVKKYGVPR GFWRILRRLV QARDDLYLHR VRVEDLVLSS VLSKDISLYR QSNLPHIAVI KRLAARSEEL PSVGDRVFYV LTAPGVRTAP QGSSDNGDSV TAGVVSRSDA IDGTDDDADG GGVEESNRRG GEPAKKRARK PPSAVCNYEV AEDPSYVREH GVPIHADKYF EQVLKAVTNV LSPVFPGGET ARKDKFLHMV LPRRLHLEPA FLPYSVKAHE CC //