ID DPOL_HCMVA STANDARD; PRT; 1242 AA. AC P08546; DT 01-AUG-1988 (REL. 08, CREATED) DT 01-NOV-1995 (REL. 32, LAST SEQUENCE UPDATE) DT 01-NOV-1995 (REL. 32, LAST ANNOTATION UPDATE) DE DNA POLYMERASE (EC 2.7.7.7). GN UL54 OR HFLF2. OS HUMAN CYTOMEGALOVIRUS (STRAIN AD169). OC VIRIDAE; DS-DNA ENVELOPED VIRUSES; HERPESVIRIDAE; BETAHERPESVIRINAE. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 87061230. RA KOUZARIDES T., BANKIER A.T., SATCHWELL S.C., WESTON K., TOMLINSON P., RA BARRELL B.G.; RL J. VIROL. 61:125-133(1987). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 87151139. RA KOUZARIDES T., BANKIER A.T., SATCHWELL S.C., WESTON K., RA TOMLINSON P., BARRELL B.G.; RL VIROLOGY 157:397-413(1987). RN [3] RP COMPLETE GENOME. RX MEDLINE; 90269039. RA CHEE M.S., BANKIER A.T., BECK S., BOHNI R., BROWN C.M., CERNY R., RA HORSNELL T., HUTCHISON C.A. III, KOUZARIDES T., MARTIGNETTI J.A., RA PREDDIE E., SATCHWELL S.C., TOMLINSON P., WESTON K.M., BARRELL B.G.; RL CURR. TOP. MICROBIOL. IMMUNOL. 154:125-169(1990). CC -!- CATALYTIC ACTIVITY: N DEOXYNUCLEOSIDE TRIPHOSPHATE = CC N PYROPHOSPHATE + DNA(N). CC -!- SIMILARITY: BELONGS TO FAMILY B OF DNA POLYMERASES. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X17403; X17403. DR EMBL; M17209; M17209. DR EMBL; M14709; M14709. DR PIR; S09817; DJBEC1. DR PROSITE; PS00116; DNA_POLYMERASE_B. KW DNA-DIRECTED DNA POLYMERASE; DNA REPLICATION; DNA-BINDING. FT CONFLICT 942 943 FV -> VF (IN REF. 3). SQ SEQUENCE 1242 AA; 137101 MW; 8077168 CN; MFFNPYLSGG VTGGAVAGGR RQRSQPGSAQ GSGKRPPQKQ FLQIVPRGVM FDGQTGLIKH KTGRLPLMFY REIKHLLSHD MVWPCPWRET LVGRVVGPIR FHTYDQTDAV LFFDSPENVS PRYRQHLVPS GNVLRFFGAT EHGYSICVNV FGQRSYFYCE YSDTDRLREV IASVGELVPE PRTPYAVSVT PATKTSIYGY GTRPVPDLQC VSISNWTMAR KIGEYLLEQG FPVYEVRVDP LTRLVIDRRI TTFGWCSVNR YDWRQQGRAS TCDIEVDCDV SDLVAVPDDS SWPRYRCLSF DIECMSGEGG FPCAEKSDDI VIQISCVCYE TGGNTAVDQG IPNGNDGRGC TSEGVIFGHS GLHLFTIGTC GQVGPDVDVY EFPSEYELLL GFMLFFQRYA PAFVTGYNIN SFDLKYILTR LEYLYKVDSQ RFCKLPTAQG GRFFLHSPAV GFKRQYAAAF PSASHNNPAS TAATKVYIAG SVVIDMYPVC MAKTNSPNYK LNTMAELYLR QRKDDLSYKD IPRCFVANAE GRAQVGRYCL QDAVLVRDLF NTINFHYEAG AIARLAKIPL RRVIFDGQQI RIYTSLLDEC ACRDFILPNH YSKGTTVPET NSVAVSPNAA IISTAAVPGD AGSVAAMFQM SPPLQSAPSS QDGVSPGSGS NSSSSVGVFS VGSGSSGGVG VSNDNHGAGG TAAVSYQGAT VFEPEVGYYN DPVAVFDFAS LYPSIIMAHN LCYSTLLVPG GEYPVDPADV YSVTLENGVT HRFVRASVRV SVLSELLNKW VSQRRAVREC MRECQDPVRR MLLDKEQMAL KVTCNAFYGF TGVVNGMMPC LPIAASITRI GRDMLERTAR FIKDNFSEPC FLHNFFNQED YVVGTREGDS EESSALPEGL ETSSGGSNER RVEARVIYGD TDSVFVRFRG LTPQALVARG PSLAHYVTAC LFVEPVKLEF EKVFVSLMMI CKKRYIGKVE GASGLSMKGV DLVRKTACEF VKGVTRDVLS LLFEDREVSE AAVRLSRLSL DEVKKYGVPR GFWRILRRLV QARDDLYLHR VRVEDLVLSS VLSKDISLYR QSNLPHIAVI KRLAARSEEL PSVGDRVFYV LTAPGVRTAP QGSSDNGDSV TAGVVSRSDA IDGTDDDADG GGVEESNRRG GEPAKKRARK PPSAVCNYEV AEDPSYVREH GVPIHADKYF EQVLKAVTNV LSPVFPGGET ARKDKFLHMV LPRRLHLEPA FLPYSVKAHE CC //