ID UDB2_RAT STANDARD; PRT; 530 AA. AC P08541; DT 01-AUG-1988 (REL. 08, CREATED) DT 01-AUG-1988 (REL. 08, LAST SEQUENCE UPDATE) DT 01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE) DE UDP-GLUCURONOSYLTRANSFERASE 2B2 PRECURSOR, MICROSOMAL (EC 2.4.1.17) DE (UDPGT) (3-HYDROXYANDROGEN SPECIFIC) (UDPGTR-4) (RLUG23). GN UGT2B2. OS RATTUS NORVEGICUS (RAT). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=LIVER; RM 87033594 RA MCKENZIE P.I.; RL J. BIOL. CHEM. 261:14112-14117(1986). RN [2] RP SEQUENCE FROM N.A. RM 91369480 RA HAQUE S.J., PETERSON D.D., NEBERT D.W., MACKENZIE P.I.; RL DNA CELL BIOL. 10:515-524(1991). RN [3] RP SEQUENCE OF 27-530 FROM N.A. RC TISSUE=LIVER; RM 86120371 RA JACKSON M.R., BURCHELL B.; RL NUCLEIC ACIDS RES. 14:779-795(1986). CC -!- FUNCTION: UDPGT IS OF MAJOR IMPORTANCE IN THE CONJUGATION AND CC SUBSEQUENT ELIMINATION OF POTENTIALLY TOXIC XENOBIOTICS AND CC ENDOGENOUS COMPOUNDS. 2B2 ACTS ON VARIOUS ENDOGENOUS STEROIDS, CC ESPECIALLY ETIOCHOLANOLONE AND ANDROSTERONE. CC -!- CATALYTIC ACTIVITY: UDP-GLUCURONATE + ACCEPTOR = UDP + ACCEPTOR CC BETA-D-GLUCORONOSIDE. CC -!- SUBCELLULAR LOCATION: MICROSOMAL. CC -!- INDUCTION: CONSTITUTIVELY EXPRESSED. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J02589; RNUDPGST. DR EMBL; M74439; RNUDPGV. DR EMBL; X03478; RNUDPGTR. DR PIR; A26064; A26064. DR PIR; A23520; A23520. DR PROSITE; PS00375; UDPGT. KW TRANSFERASE; GLYCOSYLTRANSFERASE; GLYCOPROTEIN; TRANSMEMBRANE; SIGNAL; KW MULTIGENE FAMILY; MICROSOME. FT SIGNAL 1 23 BY SIMILARITY. FT CHAIN 24 530 UDP-GLUCURONOSYLTRANSFERASE 2B2. FT TRANSMEM 494 510 POTENTIAL. FT CARBOHYD 316 316 POTENTIAL. FT CONFLICT 159 159 D -> E (IN REF. 3). FT CONFLICT 286 286 A -> S (IN REF. 3). FT CONFLICT 351 351 N -> I (IN REF. 3). FT CONFLICT 431 431 E -> V (IN REF. 2). SQ SEQUENCE 530 AA; 60985 MW; 1535845 CN; MPRKWISALF LLQISYCFKS GHCGKVLVWP MDFSHWMNIK IILDELVQRG HEVTVLKPSA YFFLDPKKSS DLKFEIFSTS ISKDELQNHF IKLLDVWTYE LPRDTCLSYS PILQNLVYEF SYFYLSICKD AVSNKQLMTK LQESKFDVLF ADPVASCGDL IAELLHIPFL YSLSFSPGHK LEKSIGKFIL PPSYVPVILS GLAGKMTFID RVKNMICMLY FDFWFERLRH KEWDTFYSEI LGRPTTVDET MSKVEIWLIR SYWDLKFPHP TLPNVDYIGG LHCKPAKPLP KDMEEFVQSS GEHGVVVFSL GSMVSNMTEE KANAIAWALA QIPQKVLWKF DGKTPATLGP NTRVYKWLPQ NDLLGHPKTK AFVTHGGANG LYEAIYHGIP MIGIPLFGDQ PDNIAHMVAK GAAVSLNIRT MSKLDFLSAL EEVIDNPFYK KNVMLLSTIH HDQPMKPLDR AVFWIEFIMR HKGAKHLRPL GHNLPWYQYH SLDVIGFLLT CFAVIAALTV KCLLFMYRFF VKKEKKMKNE //