ID UDP1$RAT STANDARD; PRT; 530 AA. AC P08541; DT 01-AUG-1988 (REL. 08, CREATED) DT 01-AUG-1988 (REL. 08, LAST SEQUENCE UPDATE) DT 01-AUG-1988 (REL. 08, LAST ANNOTATION UPDATE) DE UDP-GLUCURONOSYLTRANSFERASE PRECURSOR, MICROSOMAL (EC 2.4.1.17) DE (UDPGT) (3-HYDROXYANDROGEN SPECIFIC). OS RAT (RATTUS NORVEGICUS). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] (SEQUENCE FROM N.A.) RA MCKENZIE P.I.; RL J. BIOL. CHEM. 261:14112-14117(1986). RN [2] (LIVER, SEQUENCE OF 27-530 FROM N.A.) RA JACKSON M.R., BURCHELL B.; RL NUCLEIC ACIDS RES. 14:779-795(1986). CC -!- FUNCTION: UDPGT IS OF MAJOR IMPORTANCE IN THE CONJUGATION AND CC SUBSEQUENT ELIMINATION OF POTENTIALLY TOXIC XENOBIOTICS AND CC ENDOGENOUS COMPOUNDS. CC -!- CATALYTIC ACTIVITY: UDP-GLUCURONATE + ACCEPTOR = UDP + ACCEPTOR CC BETA-D-GLUCORONOSIDE. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J02589; RNUDPGST. DR EMBL; X03478; RNUDPGTR. KW TRANSFERASE; GLYCOSYLTRANSFERASE; MICROSOME; MULTIGENE FAMILY; SIGNAL. FT SIGNAL 1 23 FT CHAIN 24 530 UDP-GLUCURONOSYLTRANSFERASE. FT CONFLICT 159 159 D -> E (IN REF. 2). FT CONFLICT 286 286 A -> S (IN REF. 2). FT CONFLICT 351 351 N -> I (IN REF. 2). SQ SEQUENCE 530 AA; 60985 MW; 1535845 CN; MPRKWISALF LLQISYCFKS GHCGKVLVWP MDFSHWMNIK IILDELVQRG HEVTVLKPSA YFFLDPKKSS DLKFEIFSTS ISKDELQNHF IKLLDVWTYE LPRDTCLSYS PILQNLVYEF SYFYLSICKD AVSNKQLMTK LQESKFDVLF ADPVASCGDL IAELLHIPFL YSLSFSPGHK LEKSIGKFIL PPSYVPVILS GLAGKMTFID RVKNMICMLY FDFWFERLRH KEWDTFYSEI LGRPTTVDET MSKVEIWLIR SYWDLKFPHP TLPNVDYIGG LHCKPAKPLP KDMEEFVQSS GEHGVVVFSL GSMVSNMTEE KANAIAWALA QIPQKVLWKF DGKTPATLGP NTRVYKWLPQ NDLLGHPKTK AFVTHGGANG LYEAIYHGIP MIGIPLFGDQ PDNIAHMVAK GAAVSLNIRT MSKLDFLSAL EEVIDNPFYK KNVMLLSTIH HDQPMKPLDR AVFWIEFIMR HKGAKHLRPL GHNLPWYQYH SLDVIGFLLT CFAVIAALTV KCLLFMYRFF VKKEKKMKNE //