ID LDHC_HUMAN Reviewed; 332 AA. AC P07864; Q6GSG8; Q7Z7J4; DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 4. DT 20-JAN-2009, entry version 94. DE RecName: Full=L-lactate dehydrogenase C chain; DE Short=LDH-C; DE EC=1.1.1.27; DE AltName: Full=LDH testis subunit; DE AltName: Full=LDH-X; DE AltName: Full=Cancer/testis antigen 32; DE Short=CT32; GN Name=LDHC; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Testis; RX MEDLINE=87260977; PubMed=2440048; RA Millan J.L., Driscoll C.E., Goldberg E.; RT "Epitopes of human testis-specific lactate dehydrogenase deduced from RT a cDNA sequence."; RL Proc. Natl. Acad. Sci. U.S.A. 84:5311-5315(1987). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=89193640; PubMed=2930531; DOI=10.1016/0006-291X(89)90033-8; RA Takano T., Li S.S.-L.; RT "Human testicular lactate dehydrogenase-C gene is interrupted by six RT introns at positions homologous to those of LDH-A (muscle) and LDH-B RT (heart) genes."; RL Biochem. Biophys. Res. Commun. 159:579-583(1989). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Wu K., Li S.S.-L.; RT "Human testicular lactate dehydrogenase-C gene: cDNA sequence and RT putative alternative splicing at the 5' noncoding region."; RL J. Genet. Mol. Biol. 1:72-76(1990). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA], AND POSSIBLE FUNCTION. RC TISSUE=Testis; RX PubMed=14985855; DOI=10.1007/s00109-004-0526-3; RA Wang H., Zhou Z., Xu M., Li J., Xiao J., Xu Z.-Y., Sha J.; RT "A spermatogenesis-related gene expression profile in human RT spermatozoa and its potential clinical applications."; RL J. Mol. Med. 82:317-324(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain, and Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Possible role in sperm motility. CC -!- CATALYTIC ACTIVITY: (S)-lactate + NAD(+) = pyruvate + NADH. CC -!- PATHWAY: Fermentation; pyruvate fermentation to lactate; (S)- CC lactate from pyruvate: step 1/1. CC -!- SUBUNIT: Homotetramer. CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- SIMILARITY: Belongs to the LDH/MDH superfamily. LDH family. CC -!- WEB RESOURCE: Name=GeneReviews; CC URL="http://www.genetests.org/query?gene=LDHC"; CC -!- WEB RESOURCE: Name=Wikipedia; Note=Lactate dehydrogenase entry; CC URL="http://en.wikipedia.org/wiki/Lactate_dehydrogenase"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J02938; AAA59507.1; -; mRNA. DR EMBL; M24515; AAA59508.1; -; Genomic_DNA. DR EMBL; M24510; AAA59508.1; JOINED; Genomic_DNA. DR EMBL; M24511; AAA59508.1; JOINED; Genomic_DNA. DR EMBL; M24512; AAA59508.1; JOINED; Genomic_DNA. DR EMBL; M24513; AAA59508.1; JOINED; Genomic_DNA. DR EMBL; M24514; AAA59508.1; JOINED; Genomic_DNA. DR EMBL; U13680; AAA21348.1; -; mRNA. DR EMBL; AY286300; AAP37402.1; -; mRNA. DR EMBL; BC019249; AAH19249.3; -; mRNA. DR EMBL; BC064388; AAH64388.1; -; mRNA. DR EMBL; BC090043; AAH90043.1; -; mRNA. DR PIR; A30933; DEHULC. DR RefSeq; NP_002292.1; -. DR RefSeq; NP_059144.1; -. DR UniGene; Hs.654377; -. DR HSSP; P00338; 1I10. DR SMR; P07864; 2-332. DR PRIDE; P07864; -. DR Ensembl; ENSG00000166796; Homo sapiens. DR GeneID; 3948; -. DR KEGG; hsa:3948; -. DR GeneCards; GC11P018390; -. DR H-InvDB; HIX0009488; -. DR HGNC; HGNC:6544; LDHC. DR MIM; 150150; gene. DR Orphanet; 2364; Lactate dehydrogenase deficiency. DR PharmGKB; PA30328; -. DR HOGENOM; P07864; -. DR HOVERGEN; P07864; -. DR BRENDA; 1.1.1.27; 247. DR DrugBank; DB00157; NADH. DR LinkHub; P07864; -. DR NextBio; 15487; -. DR ArrayExpress; P07864; -. DR CleanEx; HS_LDHC; -. DR GermOnline; ENSG00000166796; Homo sapiens. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0005488; F:binding; IEA:InterPro. DR GO; GO:0004459; F:L-lactate dehydrogenase activity; TAS:ProtInc. DR GO; GO:0019642; P:anaerobic glycolysis; IEA:InterPro. DR GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW. DR InterPro; IPR001557; L-lactate/malate_DHase. DR InterPro; IPR011304; L-lactate_DHase. DR InterPro; IPR001236; Lactate/malate_DHase. DR InterPro; IPR015955; Lactate_DHase/Glyco_Ohase_4_C. DR Gene3D; G3DSA:3.90.110.10; lact_mal_DH; 1. DR Pfam; PF02866; Ldh_1_C; 1. DR Pfam; PF00056; Ldh_1_N; 1. DR PIRSF; PIRSF000102; Lac_mal_DH; 1. DR PRINTS; PR00086; LLDHDRGNASE. DR TIGRFAMs; TIGR01771; L-LDH-NAD; 1. DR PROSITE; PS00064; L_LDH; 1. PE 2: Evidence at transcript level; KW Cytoplasm; Glycolysis; NAD; Oxidoreductase; Polymorphism. FT INIT_MET 1 1 Removed. FT CHAIN 2 332 L-lactate dehydrogenase C chain. FT /FTId=PRO_0000168479. FT NP_BIND 29 57 NAD (By similarity). FT ACT_SITE 193 193 Proton acceptor (By similarity). FT BINDING 99 99 NAD (By similarity). FT BINDING 106 106 Substrate (By similarity). FT BINDING 138 138 NAD or substrate (By similarity). FT BINDING 169 169 Substrate (By similarity). FT BINDING 248 248 Substrate (By similarity). FT VARIANT 285 285 E -> Q (in dbSNP:rs2230150). FT /FTId=VAR_034068. FT CONFLICT 77 77 I -> V (in Ref. 1 and 2). FT CONFLICT 82 82 D -> G (in Ref. 4; AAP37402). FT CONFLICT 119 119 S -> I (in Ref. 1; AAA59507). SQ SEQUENCE 332 AA; 36311 MW; DF7047FF5BCB101B CRC64; MSTVKEQLIE KLIEDDENSQ CKITIVGTGA VGMACAISIL LKDLADELAL VDVALDKLKG EMMDLQHGSL FFSTSKITSG KDYSVSANSR IVIVTAGARQ QEGETRLALV QRNVAIMKSI IPAIVHYSPD CKILVVSNPV DILTYIVWKI SGLPVTRVIG SGCNLDSARF RYLIGEKLGV HPTSCHGWII GEHGDSSVPL WSGVNVAGVA LKTLDPKLGT DSDKEHWKNI HKQVIQSAYE IIKLKGYTSW AIGLSVMDLV GSILKNLRRV HPVSTMVKGL YGIKEELFLS IPCVLGRNGV SDVVKINLNS EEEALFKKSA ETLWNIQKDL IF //