ID PUR2_YEAST STANDARD; PRT; 802 AA. AC P07244; DT 01-APR-1988 (REL. 07, CREATED) DT 01-APR-1988 (REL. 07, LAST SEQUENCE UPDATE) DT 01-APR-1990 (REL. 14, LAST ANNOTATION UPDATE) DE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (EC 6.3.4.13) (GARS) (GLYCINAMIDE DE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE) / DE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE (EC 6.3.3.1) (AIRS) DE (PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR SYNTHASE). GN ADE5/ADE7. OS SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). OC EUKARYOTA; FUNGI; ASCOMYCOTINA; HEMIASCOMYCETES. RN [1] RP SEQUENCE FROM N.A. RM 87061006 RA HENIKOFF S.; RL J. MOL. BIOL. 190:519-528(1986). CC -!- CATALYTIC ACTIVITY: ATP + 5-PHOSPHORIBOSYLAMINE + GLYCINE = ADP + CC ORTHOPHOSPHATE + 5'PHOSPHORIBOSYLGLYCINAMIDE. CC -!- CATALYTIC ACTIVITY: ATP + 5'-PHOSPHORIBOSYL-FORMYLGLYCINAMIDINE = CC ADP + ORTHOPHOSPHATE + 5'-PHOSPHORIBOSYL-5-AMINOIMIDAZOLE. CC -!- SIMILARITY: TO OTHER GARS AND AIRS FROM BACTERIA AND EUKARYOTES. CC -!- PATHWAY: SECOND AND FIFTH STEPS IN DE NOVO PURINE BIOSYNTHESIS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X04337; SCADE57. DR PIR; A26343; A26343. DR PROSITE; PS00184; GARS. KW MULTIFUNCTIONAL ENZYME; PURINE BIOSYNTHESIS; LIGASE. FT DOMAIN 1 450 GARS. FT DOMAIN 451 802 AIRS. SQ SEQUENCE 802 AA; 86068 MW; 3311500 CN; MLNILVLGNG AREHVLVTKL AQSPTVGKIY VAPGNGGTAT MDPSRVINWD ITPDVANFAR LQSMAVEHKI NLVVPGPELP LVNGITSVFH SVGIPVFGPS VKAAQLEASK AFSKRFMSKH NIPTASYDVF TNPEEAISFL QAHTDKAFVI KADGIAAGKG VIIPSSIDES VQAIKDIMVT KQFGEEAGKQ VVIEQFLEGD EISLLTIVDG YSHFNLPVAQ DHKRIFDGDK GLNTGGMGAY APAPVATPSL LKTIDSQIVK PTIDGMRRDG MPFVGVLFTG MILVKDSKTN QLVPEVLEYN VRFGDPETQA VLSLLDDQTD LAQVFLAAAE HRLDSVNIGI DDTRSAVTVV VAAGGYPESY AKGDKITLDT DKLPPHTQIF QAGTKYDSAT DSLLTNGGRV LSVTSTAQDL RTAVDTVYEA VKCVHFQNSY YRKDIAYRAF QNSESSKVAI TYADSGVSVD NGNNLVQTIK EMVRSTRRPG ADSDIGGFGG LFDLAQAGFR QNEDTLLVGA TDGVGTKLII AQETGIHNTV GIDLVAMNVN DLVVQGAEPL FFLDYFATGA LDIQVASDFV SGVANGCIQS GCALVGGETS EMPGMYPPGH YDTNGTAVGA VLRQDILPKI NEMAAGDVLL GLASSGVHSN GFSLVRKIIQ HVALPWDAPC PWDESKTLGE GILEPTKIYV KQLLPSIRQR LLLGLAHITG GGLVENIPRA IPDHLQARVD MSTWEVPRVF KWFGQAGNVP HDDILRTFNM GVGMVLIVKR ENVKAVCDSL TEEGEIIWEL GSLQERPKDA PGCVIENGTK LY //