ID DPOL$VACCV STANDARD; PRT; 1006 AA. AC P06856; DT 01-JAN-1988 (REL. 06, CREATED) DT 01-NOV-1991 (REL. 20, LAST SEQUENCE UPDATE) DT 01-NOV-1991 (REL. 20, LAST ANNOTATION UPDATE) DE DNA POLYMERASE (EC 2.7.7.7) (GENE NAME: E9L). OS VACCINIA VIRUS (STRAIN WR). OC VIRIDAE; DS-DNA ENVELOPED VIRUSES; POXVIRIDAE. RN [1] RP SEQUENCE FROM N.A. RA GERSHON P.D., JONES E.V., MOSS B., AHN B.Y.; RL SUBMITTED (JUL-1990) TO EMBL/GENBANK/DDBJ DATA BANKS. RN [2] RP SEQUENCE OF 40-962 FROM N.A. RC MEDLINE=86233293; RA EARL P.L., JONES E.V., MOSS B.; RL PROC. NATL. ACAD. SCI. U.S.A. 83:3659-3663(1986). CC -!- CATALYTIC ACTIVITY: N DEOXYNUCLEOSIDE TRIPHOSPHATE = CC N PYROPHOSPHATE + DNA(N). CC -!- SIMILARITY: BELONGS TO FAMILY B OF DNA POLYMERASES. CC -!- PAA-R (PHOSPHONOACETATE-RESISTANCE MUTANT) IS A DRUG RESISTANCE CC MUTANT. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M36339; VACPOLRD. DR EMBL; M13213; PXVACPOL. DR PIR; A25270; DJVZZW. DR PIR; A24878; A24878. DR PROSITE; PS00116; DNA_POLYMERASE_B. KW DNA-DIRECTED DNA POLYMERASE; DNA REPLICATION; DNA-BINDING. FT VARIANT 338 338 S -> F (IN PAA-R MUTANT). FT VARIANT 372 372 G -> D (IN PAA-R MUTANT). SQ SEQUENCE 1006 AA; 116928 MW; 5428934 CN; MDVRCINWFE SHGENRFLYL KSRCRNGETV FIRFPHYFYY VVTDEIYQSL SPPPFNARPL GKMRTIDIDE TISYNLDIKD RKCSVADMWL IEEPKKRSIQ NATMDEFLNI SWFYISNGIS PDGCYSLDEQ YLTKINNGCY HCDDPRNCFA KKIPRFDIPR SYLFLDIECH FDKKFPSVFI NPISHTSYCY IDLSGKRLLF TLINEEMLTE QEIQEAVDRG CLRIQSLMEM DYERELVLCS EIVLLRIAKQ LLELTFDYVV TFNGHNFDLR YITNRLELLT GEKIIFRSPD KKEAVYLCIY ERNQSSHKGV GGMANTTFHV NNNNGTIFFD LYSFIQKSEK LDSYKLDSIS KNAFSCMGKV LNRGVREMTF IGDDTTDAKG KAAAFAKVLT TGNYVTVDED IICKVIRKDI WENGFKVVLL CPTLPNDTYK LSFGKDDVDL AQMYKDYNLN IALDMARYCI HDACLCQYLW EYYGVETKTD AGASTYVLPQ SMVFEYRAST VIKGPLLKLL LETKTILVRS ETKQKFPYEG GKVFAPKQKM FSNNVLIFDY NSLYPNVCIF GNLSPETLVG VVVSTNRLEE EINNQLLLQK YPPPRYITVH CEPRLPNLIS EIAIFDRSIE GTIPRLLRTF LAERARYKKM LKQATSSTEK AIYDSMQYTY KIVANSVYGL MGFRNSALYS YASAKSCTSI GRRMILYLES VLNGAELSNG MLRFANPLSN PFYMDDRDIN PIVKTSLPID YRFRFRSVYG DTDSVFTEID SQDVDKSIEI AKELERLINN RVLFNNFKIE FEAVYKNLIM QSKKKYTTMK YSASSNSKSV PERINKGTSE TRRDVSKFHK NMIKTYKTRL SEMLSEGRMN SNQVCIDILR SLETDLRSEF DSRSSPLELF MLSRMHHSNY KSADNPNMYL VTEYNKNNPE TIELGERYYF AYICPANVPW TKKLVNIKTY ETIIDRSFKL GSDQRIFYEV YFKRLTSEIV NLLDNKVLCI SFFERMFGSK PTFYEA //