ID DPOL$VACCV STANDARD; PRT; 937 AA. AC P06856; DT 01-JAN-1988 (REL. 06, CREATED) DT 01-JAN-1988 (REL. 06, LAST SEQUENCE UPDATE) DT 01-FEB-1991 (REL. 17, LAST ANNOTATION UPDATE) DE DNA-DIRECTED DNA POLYMERASE (EC 2.7.7.7) (GENE NAME: E9L). OS VACCINIA VIRUS (STRAIN WR). OC VIRIDAE; DS-DNA ENVELOPED VIRUSES; POXVIRIDAE. RN [1] (SEQUENCE FROM N.A.) RA EARL P.L., JONES E.V., MOSS B.; RL PROC. NATL. ACAD. SCI. U.S.A. 83:3659-3663(1986). CC -!- CATALYTIC ACTIVITY: N DEOXYNUCLEOSIDE TRIPHOSPHATE = CC N PYROPHOSPHATE + DNA(N). CC -!- SIMILARITY: BELONGS TO FAMILY B OF DNA POLYMERASES. CC -!- PAA-R (PHOSPHONOACETATE-RESISTANCE MUTANT) IS A DRUG RESISTANCE CC MUTANT. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M13213; PXVACPOL. DR PIR; A25270; DJVZZW. DR PIR; A24878; A24878. DR PROSITE; PS00116; DNA_POLYMERASE_B. KW DNA-DIRECTED DNA POLYMERASE; DNA REPLICATION; DNA-BINDING. FT VARIANT 313 313 S -> F (IN PAA-R MUTANT). FT VARIANT 347 347 G -> D (IN PAA-R MUTANT). SQ SEQUENCE 937 AA; 108446 MW; 4695797 CN; MVRPYLYDFL ITFIYVVTDE IYQSLSPPPF NARPLGKMRT IDIDETISYN LDIKDRKCSV ADMWLIEEPK KRSIQNATMD EFLNISWFYI SNGISPDGCY SLDEQYLTKI NNGCYHCDDP RNCFAKKIPR FDIPRSYLFL DIECHFDKKF PSVFINPISH TSYCYIDLSG KRLLFTLINE EMLTEQEIQE AVDRGCLRIQ SLMEMDYERE LVLCSEIVLL RIAKQLLELT FDYVVTFNGH NFDLRYITNR LELLTGEKII FRSPDKKEAV YLCIYERNQS SHKGVGGMAN TTFHVNNNNG TIFFDLYSFI QKSEKLDSYK LDSISKNAFS CMGKVLNRGV REMTFIGDDT TDAKGKAAAF AKVLTTGNYV TVDEDIICKV IRKDIWENGF KVVLLCPTLP NDTYKLSFGK DDVDLAQMYK DYNLNIALDM ARYCIHDACL CQYLWEYYGV ETKTDAGAST YVLPQSMVFE YRASTVIKGP LLKLLLETKT ILVRSETKQK FPYEGGKVFA PKQKMFSNNV LIFDYNSLYP NVCIFGNLSP ETLVGVVVST NRLEEEINNQ LLLQKYPPPR YITVHCEPRL PNLISEIAIF DRSIEGTIPR LLRTFLAERA RYKKMLKQAT SSTEKAIYDS MQYTYKIVAN SVYGLMGFRN SALYSYASAK SCTSIGRRMI LYLESVLNGA ELSNGMLRFA NPLSNPFYMD DRDINPIVKT SLPIDYRFRF RSVYGDTDSV FTEIDSQDVD KSIEIAKELE RLINNRVLFN NFKIEFEAVY KNLIMQSKKK YTTMKYSASS NSKSVPERIN KGTSETRRDV SKFHKNMIKT YKTRLSEMLS EGRMNSNQVC IDILRSLETD LRSEFDSRSS PLELFMLSRM HHSNYKSADN PNMYLVTEYN KNNPETIELG ERYYFAYICP ANVPWTKKLV NIKTYETIID RSFKLGS //