ID DPOL_VACCV STANDARD; PRT; 1006 AA. AC P06856; DT 01-JAN-1988 (Rel. 06, Created) DT 01-NOV-1991 (Rel. 20, Last sequence update) DT 15-DEC-1998 (Rel. 37, Last annotation update) DE DNA POLYMERASE (EC 2.7.7.7). GN E9L. OS Vaccinia virus (strain WR). OC Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae; OC Orthopoxvirus. OX NCBI_TaxID=10254; RN [1] RP SEQUENCE FROM N.A. RA Gershon P.D., Jones E.V., Moss B., Ahn B.-Y.; RL Submitted (JUL-1990) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 40-962 FROM N.A. RX MEDLINE=86233293; PubMed=3012524; RA Earl P.L., Jones E.V., Moss B.; RT "Homology between DNA polymerases of poxviruses, herpesviruses, and RT adenoviruses: nucleotide sequence of the vaccinia virus DNA RT polymerase gene."; RL Proc. Natl. Acad. Sci. U.S.A. 83:3659-3663(1986). CC -!- CATALYTIC ACTIVITY: N DEOXYNUCLEOSIDE TRIPHOSPHATE = CC N PYROPHOSPHATE + DNA(N). CC -!- SIMILARITY: BELONGS TO DNA POLYMERASE TYPE-B FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M36339; AAB59829.1; -. DR EMBL; M13213; AAA98419.1; ALT_INIT. DR PIR; A25270; DJVZZW. DR PIR; A24878; A24878. DR INTERPRO; IPR002064; -. DR PFAM; PF00136; DNA_pol_B; 1. DR PRINTS; PR00106; DNAPOLB. DR PROSITE; PS00116; DNA_POLYMERASE_B; 1. KW Transferase; DNA-directed DNA polymerase; DNA replication; KW DNA-binding. FT VARIANT 338 338 S -> F (IN PAA-R MUTANT; FT PHOSPHONOACETATE-RESISTANT). FT VARIANT 372 372 G -> D (IN PAA-R MUTANT; FT PHOSPHONOACETATE-RESISTANT). SQ SEQUENCE 1006 AA; 116928 MW; BB663635CC82446F CRC64; MDVRCINWFE SHGENRFLYL KSRCRNGETV FIRFPHYFYY VVTDEIYQSL SPPPFNARPL GKMRTIDIDE TISYNLDIKD RKCSVADMWL IEEPKKRSIQ NATMDEFLNI SWFYISNGIS PDGCYSLDEQ YLTKINNGCY HCDDPRNCFA KKIPRFDIPR SYLFLDIECH FDKKFPSVFI NPISHTSYCY IDLSGKRLLF TLINEEMLTE QEIQEAVDRG CLRIQSLMEM DYERELVLCS EIVLLRIAKQ LLELTFDYVV TFNGHNFDLR YITNRLELLT GEKIIFRSPD KKEAVYLCIY ERNQSSHKGV GGMANTTFHV NNNNGTIFFD LYSFIQKSEK LDSYKLDSIS KNAFSCMGKV LNRGVREMTF IGDDTTDAKG KAAAFAKVLT TGNYVTVDED IICKVIRKDI WENGFKVVLL CPTLPNDTYK LSFGKDDVDL AQMYKDYNLN IALDMARYCI HDACLCQYLW EYYGVETKTD AGASTYVLPQ SMVFEYRAST VIKGPLLKLL LETKTILVRS ETKQKFPYEG GKVFAPKQKM FSNNVLIFDY NSLYPNVCIF GNLSPETLVG VVVSTNRLEE EINNQLLLQK YPPPRYITVH CEPRLPNLIS EIAIFDRSIE GTIPRLLRTF LAERARYKKM LKQATSSTEK AIYDSMQYTY KIVANSVYGL MGFRNSALYS YASAKSCTSI GRRMILYLES VLNGAELSNG MLRFANPLSN PFYMDDRDIN PIVKTSLPID YRFRFRSVYG DTDSVFTEID SQDVDKSIEI AKELERLINN RVLFNNFKIE FEAVYKNLIM QSKKKYTTMK YSASSNSKSV PERINKGTSE TRRDVSKFHK NMIKTYKTRL SEMLSEGRMN SNQVCIDILR SLETDLRSEF DSRSSPLELF MLSRMHHSNY KSADNPNMYL VTEYNKNNPE TIELGERYYF AYICPANVPW TKKLVNIKTY ETIIDRSFKL GSDQRIFYEV YFKRLTSEIV NLLDNKVLCI SFFERMFGSK PTFYEA //