ID DPOL_VACCV STANDARD; PRT; 1006 AA. AC P06856; DT 01-JAN-1988 (Rel. 06, Created) DT 01-NOV-1991 (Rel. 20, Last sequence update) DT 15-DEC-1998 (Rel. 37, Last annotation update) DE DNA POLYMERASE (EC 2.7.7.7). GN E9L. OS Vaccinia virus (strain WR). OC Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae; OC Orthopoxvirus. RN [1] RP SEQUENCE FROM N.A. RA Gershon P.D., Jones E.V., Moss B., Ahn B.-Y.; RL Submitted (JUL-1990) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 40-962 FROM N.A. RX MEDLINE; 86233293. RA Earl P.L., Jones E.V., Moss B.; RT "Homology between DNA polymerases of poxviruses, herpesviruses, and RT adenoviruses: nucleotide sequence of the vaccinia virus DNA RT polymerase gene."; RL Proc. Natl. Acad. Sci. U.S.A. 83:3659-3663(1986). CC -!- CATALYTIC ACTIVITY: N DEOXYNUCLEOSIDE TRIPHOSPHATE = CC N PYROPHOSPHATE + DNA(N). CC -!- SIMILARITY: BELONGS TO DNA POLYMERASE TYPE-B FAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M36339; AAB59829.1; -. DR EMBL; M13213; AAA98419.1; ALT_INIT. DR PIR; A25270; DJVZZW. DR PIR; A24878; A24878. DR INTERPRO; IPR002064; -. DR PFAM; PF00136; DNA_pol_B; 1. DR PRINTS; PR00106; DNAPOLB. DR PROSITE; PS00116; DNA_POLYMERASE_B; 1. KW Transferase; DNA-directed DNA polymerase; DNA replication; KW DNA-binding. FT VARIANT 338 338 S -> F (IN PAA-R MUTANT; FT PHOSPHONOACETATE-RESISTANT). FT VARIANT 372 372 G -> D (IN PAA-R MUTANT; FT PHOSPHONOACETATE-RESISTANT). SQ SEQUENCE 1006 AA; 116928 MW; BB663635CC82446F CRC64; MDVRCINWFE SHGENRFLYL KSRCRNGETV FIRFPHYFYY VVTDEIYQSL SPPPFNARPL GKMRTIDIDE TISYNLDIKD RKCSVADMWL IEEPKKRSIQ NATMDEFLNI SWFYISNGIS PDGCYSLDEQ YLTKINNGCY HCDDPRNCFA KKIPRFDIPR SYLFLDIECH FDKKFPSVFI NPISHTSYCY IDLSGKRLLF TLINEEMLTE QEIQEAVDRG CLRIQSLMEM DYERELVLCS EIVLLRIAKQ LLELTFDYVV TFNGHNFDLR YITNRLELLT GEKIIFRSPD KKEAVYLCIY ERNQSSHKGV GGMANTTFHV NNNNGTIFFD LYSFIQKSEK LDSYKLDSIS KNAFSCMGKV LNRGVREMTF IGDDTTDAKG KAAAFAKVLT TGNYVTVDED IICKVIRKDI WENGFKVVLL CPTLPNDTYK LSFGKDDVDL AQMYKDYNLN IALDMARYCI HDACLCQYLW EYYGVETKTD AGASTYVLPQ SMVFEYRAST VIKGPLLKLL LETKTILVRS ETKQKFPYEG GKVFAPKQKM FSNNVLIFDY NSLYPNVCIF GNLSPETLVG VVVSTNRLEE EINNQLLLQK YPPPRYITVH CEPRLPNLIS EIAIFDRSIE GTIPRLLRTF LAERARYKKM LKQATSSTEK AIYDSMQYTY KIVANSVYGL MGFRNSALYS YASAKSCTSI GRRMILYLES VLNGAELSNG MLRFANPLSN PFYMDDRDIN PIVKTSLPID YRFRFRSVYG DTDSVFTEID SQDVDKSIEI AKELERLINN RVLFNNFKIE FEAVYKNLIM QSKKKYTTMK YSASSNSKSV PERINKGTSE TRRDVSKFHK NMIKTYKTRL SEMLSEGRMN SNQVCIDILR SLETDLRSEF DSRSSPLELF MLSRMHHSNY KSADNPNMYL VTEYNKNNPE TIELGERYYF AYICPANVPW TKKLVNIKTY ETIIDRSFKL GSDQRIFYEV YFKRLTSEIV NLLDNKVLCI SFFERMFGSK PTFYEA //