ID MPIP_SCHPO Reviewed; 596 AA. AC P06652; DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1995, sequence version 2. DT 15-MAY-2007, entry version 68. DE M-phase inducer phosphatase (EC 3.1.3.48) (Mitosis initiation protein) DE (P80). GN Name=cdc25; ORFNames=SPAC24H6.05; OS Schizosaccharomyces pombe (Fission yeast). OC Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; OC Schizosaccharomyces. OX NCBI_TaxID=4896; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=86161690; PubMed=3955656; DOI=10.1016/0092-8674(86)90546-5; RA Russell P., Nurse P.; RT "cdc25+ functions as an inducer in the mitotic control of fission RT yeast."; RL Cell 45:145-153(1986). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 38366 / 972; RX MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724; RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., RA Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., RA Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., RA Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., RA James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., RA Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., RA Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., RA Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., RA Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., RA Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., RA Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., RA Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., RA Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., RA Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., RA Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., RA Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., RA Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., RA Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., RA Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., RA Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., RA Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., RA Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.; RT "The genome sequence of Schizosaccharomyces pombe."; RL Nature 415:871-880(2002). CC -!- FUNCTION: This protein functions as a dosage-dependent inducer in CC mitotic control. It is a tyrosine protein phosphatase required for CC progression of the cell cycle. It may directly dephosphorylate CC p34(cdc2) and activate the p34(cdc2) kinase activity. CC -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein CC tyrosine + phosphate. CC -!- SIMILARITY: Belongs to the MPI phosphatase family. CC -!- SIMILARITY: Contains 1 rhodanese domain. CC -!- CAUTION: Ref.1 (AAA35294) sequence differs from that shown due to CC a frameshift in position 571. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M13158; AAA35294.1; ALT_FRAME; Genomic_DNA. DR EMBL; Z54142; CAA90849.1; -; Genomic_DNA. DR PIR; S62407; S62407. DR HSSP; P30305; 1QB0. DR IntAct; P06652; -. DR KEGG; spo:SPAC24H6.05; -. DR GeneDB_Spombe; SPAC24H6.05; -. DR BioCyc; SPOM-XXX-01:SPOM-XXX-01-000677-MONOMER; -. DR ArrayExpress; P06652; -. DR GermOnline; SPAC24H6.05; Schizosaccharomyces pombe. DR GO; GO:0005829; C:cytosol; IDA:GeneDB_SPombe. DR GO; GO:0005634; C:nucleus; IDA:GeneDB_SPombe. DR GO; GO:0004721; F:phosphoprotein phosphatase activity; IDA:GeneDB_SPombe. DR GO; GO:0005515; F:protein binding; IPI:GeneDB_SPombe. DR GO; GO:0000076; P:DNA replication checkpoint; IMP:GeneDB_SPombe. DR GO; GO:0000079; P:regulation of cyclin-dependent protein kina...; TAS:GeneDB_SPombe. DR GO; GO:0007346; P:regulation of progression through mitotic c...; IMP:GeneDB_SPombe. DR InterPro; IPR000751; MPI_Phosphatase. DR InterPro; IPR001763; Rhodanese-like. DR Gene3D; G3DSA:3.40.250.10; G3DSA:3.40.250.10; 1. DR PANTHER; PTHR10828; MPI_Phosphatase; 1. DR Pfam; PF00581; Rhodanese; 1. DR PRINTS; PR00716; MPIPHPHTASE. DR SMART; SM00450; RHOD; 1. DR PROSITE; PS50206; RHODANESE_3; 1. KW Cell cycle; Cell division; Complete proteome; Hydrolase; Mitosis; KW Protein phosphatase. FT CHAIN 1 596 M-phase inducer phosphatase. FT /FTId=PRO_0000198661. FT DOMAIN 429 533 Rhodanese. FT ACT_SITE 480 480 By similarity. SQ SEQUENCE 596 AA; 66566 MW; CF8D430FC7BD38C1 CRC64; MDSPLSSLSF TNTLSGKRNV LRPAARELKL MSDRNANQEL DFFFPKSKHI ASTLVDPFGK TCSTASPASS LAADMSMNMH IDESPALPTP RRTLFRSLSC TVETPLANKT IVSPLPESPS NDALTESYFF RQPASKYSIT QDSPRVSSTI AYSFKPKASI ALNTTKSEAT RSSLSSSSFD SYLRPNVSRS RSSGNAPPFL RSRSSSSYSI NKKKGTSGGQ ATRHLTYALS RTCSQSSNTT SLLESCLTDD TDDFELMSDH EDTFTMGKVA DLPESSVELV EDAASIQRPN SDFGACNDNS LDDLFQASPI KPIDMLPKIN KDIAFPSLKV RSPSPMAFAM QEDAEYDEQD TPVLRRTQSM FLNSTRLGLF KSQDLVCVTP KQSTKESERF ISSHVEDLSL PCFAVKEDSL KRITQETLLG LLDGKFKDIF DKCIIIDCRF EYEYLGGHIS TAVNLNTKQA IVDAFLSKPL THRVALVFHC EHSAHRAPHL ALHFRNTDRR MNSHRYPFLY YPEVYILHGG YKSFYENHKN RCDPINYVPM NDASHVMTCT KAMNNFKRNA TFMRTKSYTF GQSVLASPDV NDSPTAMHSL STLRRF //