ID MPIP_SCHPO STANDARD; PRT; 580 AA. AC P06652; DT 01-JAN-1988 (REL. 06, CREATED) DT 01-JAN-1988 (REL. 06, LAST SEQUENCE UPDATE) DT 01-APR-1993 (REL. 25, LAST ANNOTATION UPDATE) DE M-PHASE INDUCER PHOSPHATASE (EC 3.1.3.48) (MITOSIS INITIATION PROTEIN) DE (P80). GN CDC25+. OS SCHIZOSACCHAROMYCES POMBE (FISSION YEAST). OC EUKARYOTA; FUNGI; ASCOMYCOTINA; HEMIASCOMYCETES. RN [1] RP SEQUENCE FROM N.A. RM 86161690 RA RUSSELL P., NURSE P.; RL CELL 45:145-153(1986). CC -!- FUNCTION: THIS PROTEIN FUNCTIONS AS A DOSAGE-DEPENDENT INDUCER IN CC MITOTIC CONTROL. IT IS A TYROSINE PROTEIN PHOSPHATASE REQUIRED FOR CC PROGRESSION OF THE CELL CYCLE. IT MAY DIRECTLY DEPHOSPHORYLATE CC P34(CDC2) AND ACTIVATE THE P34(CDC2) KINASE ACTIVITY. CC -!- CATALYTIC ACTIVITY: PROTEIN TYROSINE PHOSPHATE + H(2)O = CC PROTEIN TYROSINE + ORTHOPHOSPHATE. CC -!- SIMILARITY: STRONG, TO OTHER SPECIES M-PHASE INDUCER PHOSPHATASE CC AND IN GENERAL TO PROTEIN-TYROSINE PHOSPHATASES. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M13158; SPCDC25. DR PIR; A25301; A25301. KW CELL DIVISION; MITOSIS; HYDROLASE. FT ACT_SITE 480 480 BY SIMILARITY. SQ SEQUENCE 580 AA; 65125 MW; 1771983 CN; MDSPLSSLSF TNTLSGKRNV LRPAARELKL MSDRNANQEL DFFFPKSKHI ASTLVDPFGK TCSTASPASS LAADMSMNMH IDESPALPTP RRTLFRSLSC TVETPLANKT IVSPLPESPS NDALTESYFF RQPASKYSIT QDSPRVSSTI AYSFKPKASI ALNTTKSEAT RSSLSSSSFD SYLRPNVSRS RSSGNAPPFL RSRSSSSYSI NKKKGTSGGQ ATRHLTYALS RTCSQSSNTT SLLESCLTDD TDDFELMSDH EDTFTMGKVA DLPESSVELV EDAASIQRPN SDFGACNDNS LDDLFQASPI KPIDMLPKIN KDIAFPSLKV RSPSPMAFAM QEDAEYDEQD TPVVRRTQSM FLNSTRLGLF KSQDLVCVTP KQSTKESERF ISSHVEDLSL PCFAVKEDSL KRITQETLLG LLDGKFKDIF DKCIIIDCRF EYEYLGGHIS TAVNLNTKQA IVDAFLSKPL THRVALVFHC EHSAHRAPHL ALHFRNTDRR MNSHRYPFLY YPEVYILHGG YKSFYENHKN RCDPINYVPM NDRSHVMTCT KAMNNFKRNA TFMRTKSYTF WPKCVSFPRR //