ID NU4LM_RAT Reviewed; 98 AA. AC P05507; DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 29-OCT-2014, entry version 96. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L; DE EC=1.6.5.3; DE AltName: Full=NADH dehydrogenase subunit 4L; GN Name=Mtnd4l; Synonyms=mt-Nd4l, Nd4l; OS Rattus norvegicus (Rat). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=Wistar; RX PubMed=2504926; DOI=10.1007/BF02602930; RA Gadaleta G., Pepe G., de Candia G., Quagliariello C., Sbisa E., RA Saccone C.; RT "The complete nucleotide sequence of the Rattus norvegicus RT mitochondrial genome: cryptic signals revealed by comparative analysis RT between vertebrates."; RL J. Mol. Evol. 28:497-516(1989). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=Sprague-Dawley; RA Grosskopf R., Feldmann H.; RT "Analysis of a DNA segment from rat liver mitochondria containing the RT genes for the cytochrome oxidase subunits I, II, II, ATPase subunit 6, RT and several tRNA genes."; RL Curr. Genet. 4:151-158(1981). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone (By similarity). {ECO:0000250}. CC -!- CATALYTIC ACTIVITY: NADH + ubiquinone + 5 H(+)(In) = NAD(+) + CC ubiquinol + 4 H(+)(Out). CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi- CC pass membrane protein {ECO:0000250}. CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X14848; CAA32962.1; -; Genomic_DNA. DR EMBL; J01435; AAD15022.1; -; Genomic_DNA. DR PIR; S04755; S04755. DR RefSeq; AP_004900.1; AC_000022.2. DR RefSeq; YP_665637.1; NC_001665.2. DR GeneID; 26200; -. DR KEGG; rno:26200; -. DR CTD; 4539; -. DR RGD; 620494; mt-Nd4l. DR eggNOG; NOG260597; -. DR HOGENOM; HOG000113880; -. DR HOVERGEN; HBG071122; -. DR InParanoid; P05507; -. DR KO; K03882; -. DR PhylomeDB; P05507; -. DR NextBio; 607989; -. DR PRO; PR:P05507; -. DR Genevestigator; P05507; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro. DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K. DR PANTHER; PTHR11434; PTHR11434; 1. DR Pfam; PF00420; Oxidored_q2; 1. PE 3: Inferred from homology; KW Complete proteome; Electron transport; Membrane; Mitochondrion; NAD; KW Oxidoreductase; Reference proteome; Respiratory chain; Transmembrane; KW Transmembrane helix; Transport; Ubiquinone. FT CHAIN 1 98 NADH-ubiquinone oxidoreductase chain 4L. FT /FTId=PRO_0000118483. FT TRANSMEM 2 22 Helical. {ECO:0000255}. FT TRANSMEM 26 46 Helical. {ECO:0000255}. FT TRANSMEM 59 79 Helical. {ECO:0000255}. FT CONFLICT 71 71 A -> V (in Ref. 2; AAD15022). FT {ECO:0000305}. FT CONFLICT 85 85 H -> Y (in Ref. 1; CAA32962). FT {ECO:0000305}. SQ SEQUENCE 98 AA; 10633 MW; A22AA1102433CA7E CRC64; MTSAFLNLTM AFTLSLLGTF MFRSHLMSTL LCLEGMMLSL FVMTSTSTLN SNSMISMTIP ITILVFAACE AAVGLALLVK ISNTHGTDYV QNLNLLQC //