ID TBA2_MOUSE STANDARD; PRT; 451 AA. AC P05213; DT 13-AUG-1987 (REL. 05, CREATED) DT 13-AUG-1987 (REL. 05, LAST SEQUENCE UPDATE) DT 01-NOV-1997 (REL. 35, LAST ANNOTATION UPDATE) DE TUBULIN ALPHA-2 CHAIN. GN TUBA2. OS MUS MUSCULUS (MOUSE). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA; OC RODENTIA; SCIUROGNATHI; MURIDAE; MURINAE; MUS. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 87064538. RA VILLASANTE A., WANG D., DOBNER P., DOLPH P., LEWIS S.A., COWAN N.J.; RT "Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis- RT specific expression of two sister genes."; RL MOL. CELL. BIOL. 6:2409-2419(1986). RN [2] RP SEQUENCE OF 100-451 FROM N.A. RX MEDLINE; 85289512. RA LEWIS S.A., LEE M.G.S., COWAN N.J.; RT "Five mouse tubulin isotypes and their regulated expression during RT development."; RL J. CELL BIOL. 101:852-861(1985). CC -!- FUNCTION: TUBULIN IS THE MAJOR CONSTITUENT OF MICROTUBULES. IT CC BINDS TWO MOLES OF GTP, ONE AT AN EXCHANGEABLE SITE ON THE BETA CC CHAIN AND ONE AT A NONEXCHANGEABLE SITE ON THE ALPHA-CHAIN. CC -!- SUBUNIT: DIMER OF ALPHA AND BETA CHAINS. CC -!- TISSUE SPECIFICITY: UBIQUITOUSLY EXPRESSED WITH HIGHEST LEVELS IN CC SPLEEN, THYMUS AND IMMATURE BRAIN. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M13446; G202210; -. DR EMBL; M28727; G202225; -. DR MGD; MGI:107804; TUBA2. DR PROSITE; PS00227; TUBULIN; 1. DR PFAM; PF00091; tubulin; 1. KW MICROTUBULES; GTP-BINDING; MULTIGENE FAMILY. FT NP_BIND 142 148 GTP (POTENTIAL). FT SITE 451 451 INVOLVED IN POLYMERIZATION. FT CONFLICT 135 136 FL -> LF (IN REF. 2). SQ SEQUENCE 451 AA; 50165 MW; E90BDB76 CRC32; MRECISIHVG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFN TFFSETGAGK HVPRAVFVDL EPTVIDEVRT GTYRQLFHPE QLITGKEDAA NNYARGHYTI GKEIIDLVLD RIRKLADQCT GLQGFLVFHS FGGGTGSGFT SLLMERLSVD YGKKSKLEFS IYPAPQVSTA VVEPYNSILT THTTLEHSDC AFMVDNEAIY DICRRNLDIE RPTYTNLNRL ISQIVSSITA SLRFDGALNV DLTEFQTNLV PYPRIHFPLA TYAPVISAEK AYHEQLSVAE ITNACFEPAN QMVKCDPRHG KYMACCLLYR GDVVPKDVNA AIATIKTKRT IQFVDWCPTG FKVGINYQPP TVVPGGDLAK VQRAVCMLSN TTAIAEAWAR LDHKFDLMYA KRAFVHWYVG EGMEEGEFSE AREDMAALEK DYEEVGVDSV EGEGEEEGEE Y //