ID POL_HV1Z6 Reviewed; 148 AA. AC P04586; DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot. DT 13-AUG-1987, sequence version 1. DT 08-MAR-2011, entry version 99. DE RecName: Full=Gag-Pol polyprotein; DE AltName: Full=Pr160Gag-Pol; DE Contains: DE RecName: Full=Integrase; DE Short=IN; DE Flags: Fragment; GN Name=gag-pol; OS Human immunodeficiency virus type 1 group M subtype D (isolate Z6) OS (HIV-1). OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11708; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RX MEDLINE=87248097; PubMed=3036660; DOI=10.1016/0378-1119(87)90396-9; RA Srinivasan A., Anand R., York D., Ranganathan P., Feorino P., RA Schochetman G., Curran J., Kalyanaraman V.S., Luciw P.A., RA Sanchez-Pescador R.; RT "Molecular characterization of human immunodeficiency virus from RT Zaire: nucleotide sequence analysis identifies conserved and variable RT domains in the envelope gene."; RL Gene 52:71-82(1987). RN [2] RP STRUCTURE BY NMR OF 80-130. RX PubMed=7632683; DOI=10.1021/bi00031a002; RA Lodi P.J., Ernst J.A., Kuszewski J., Hickman A.B., Engelman A., RA Craigie R., Clore G.M., Gronenborn A.M.; RT "Solution structure of the DNA binding domain of HIV-1 integrase."; RL Biochemistry 34:9826-9833(1995). CC -!- FUNCTION: Integrase performs the integration of the newly CC synthesized dsDNA copy of the viral genome into the host CC chromosome. The integrated DNA is called provirus. CC -!- PTM: Specific enzymatic cleavages by the viral protease yield CC mature proteins (By similarity). CC -!- SIMILARITY: Contains 1 integrase catalytic domain. CC -!- SIMILARITY: Contains 1 integrase-type DNA-binding domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; K03458; AAA45376.1; -; Genomic_RNA. DR PIR; A26192; A26192. DR PDB; 1IHV; NMR; -; A/B=80-130. DR PDB; 1IHW; NMR; -; A/B=80-130. DR PDBsum; 1IHV; -. DR PDBsum; 1IHW; -. DR ProteinModelPortal; P04586; -. DR SMR; P04586; 5-130. DR MEROPS; A02.001; -. DR Reactome; REACT_6185; HIV Infection. DR GO; GO:0005829; C:cytosol; EXP:Reactome. DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW. DR GO; GO:0008907; F:integrase activity; IEA:InterPro. DR GO; GO:0030260; P:entry into host cell; TAS:Reactome. DR GO; GO:0019047; P:provirus integration; EXP:Reactome. DR GO; GO:0006278; P:RNA-dependent DNA replication; TAS:Reactome. DR GO; GO:0019061; P:uncoating of virus; TAS:Reactome. DR InterPro; IPR001037; Integrase_C_retrovir. DR InterPro; IPR001584; Integrase_cat-core. DR InterPro; IPR012337; RNaseH-like. DR Gene3D; G3DSA:2.30.30.10; Integrase_C; 1. DR Pfam; PF00552; Integrase; 1. DR SUPFAM; SSF50122; Integrase_C; 1. DR SUPFAM; SSF53098; RNaseH_fold; 1. DR PROSITE; PS00141; ASP_PROTEASE; PARTIAL. DR PROSITE; PS50994; INTEGRASE; 1. DR PROSITE; PS51027; INTEGRASE_DBD; 1. PE 1: Evidence at protein level; KW 3D-structure; AIDS; DNA integration; DNA recombination; Endonuclease; KW Hydrolase; Nuclease. FT CHAIN <1 148 Gag-Pol polyprotein. FT /FTId=PRO_0000261289. FT CHAIN <1 148 Integrase (By similarity). FT /FTId=PRO_0000042448. FT DOMAIN <1 64 Integrase catalytic. FT DNA_BIND 83 130 Integrase-type. FT NON_TER 1 1 FT STRAND 82 88 FT STRAND 93 115 FT STRAND 117 121 FT HELIX 122 124 FT STRAND 125 129 SQ SEQUENCE 148 AA; 16840 MW; A0DD31618CF0FC0E CRC64; IPYNPQSQGV VESMNKELKK IIGQVRDQAE HLKTAVQMAV FIHNFKRKGG IGGYSAGERI IDIIATDIQT KELQKQITKI QNFRVYYRDS RDPIWKGPAK LLWKGEGAVV IQDNSDIKVV PRRKVKIIRD YGKQMAGDDC VASRQDED //