ID   POL_HV1Z6               Reviewed;         148 AA.
AC   P04586;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   08-FEB-2011, entry version 98.
DE   RecName: Full=Gag-Pol polyprotein;
DE   AltName: Full=Pr160Gag-Pol;
DE   Contains:
DE     RecName: Full=Integrase;
DE              Short=IN;
DE   Flags: Fragment;
GN   Name=gag-pol;
OS   Human immunodeficiency virus type 1 group M subtype D (isolate Z6)
OS   (HIV-1).
OC   Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae;
OC   Lentivirus; Primate lentivirus group.
OX   NCBI_TaxID=11708;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   MEDLINE=87248097; PubMed=3036660; DOI=10.1016/0378-1119(87)90396-9;
RA   Srinivasan A., Anand R., York D., Ranganathan P., Feorino P.,
RA   Schochetman G., Curran J., Kalyanaraman V.S., Luciw P.A.,
RA   Sanchez-Pescador R.;
RT   "Molecular characterization of human immunodeficiency virus from
RT   Zaire: nucleotide sequence analysis identifies conserved and variable
RT   domains in the envelope gene.";
RL   Gene 52:71-82(1987).
RN   [2]
RP   STRUCTURE BY NMR OF 80-130.
RX   PubMed=7632683; DOI=10.1021/bi00031a002;
RA   Lodi P.J., Ernst J.A., Kuszewski J., Hickman A.B., Engelman A.,
RA   Craigie R., Clore G.M., Gronenborn A.M.;
RT   "Solution structure of the DNA binding domain of HIV-1 integrase.";
RL   Biochemistry 34:9826-9833(1995).
CC   -!- FUNCTION: Integrase performs the integration of the newly
CC       synthesized dsDNA copy of the viral genome into the host
CC       chromosome. The integrated DNA is called provirus.
CC   -!- PTM: Specific enzymatic cleavages by the viral protease yield
CC       mature proteins (By similarity).
CC   -!- SIMILARITY: Contains 1 integrase catalytic domain.
CC   -!- SIMILARITY: Contains 1 integrase-type DNA-binding domain.
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DR   EMBL; K03458; AAA45376.1; -; Genomic_RNA.
DR   PIR; A26192; A26192.
DR   PDB; 1IHV; NMR; -; A/B=80-130.
DR   PDB; 1IHW; NMR; -; A/B=80-130.
DR   PDBsum; 1IHV; -.
DR   PDBsum; 1IHW; -.
DR   ProteinModelPortal; P04586; -.
DR   SMR; P04586; 5-130.
DR   MEROPS; A02.001; -.
DR   Reactome; REACT_6185; HIV Infection.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0008907; F:integrase activity; IEA:InterPro.
DR   GO; GO:0030260; P:entry into host cell; TAS:Reactome.
DR   GO; GO:0019047; P:provirus integration; TAS:Reactome.
DR   GO; GO:0006278; P:RNA-dependent DNA replication; TAS:Reactome.
DR   GO; GO:0019061; P:uncoating of virus; TAS:Reactome.
DR   InterPro; IPR001037; Integrase_C_retrovir.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR012337; RNaseH-like.
DR   Gene3D; G3DSA:2.30.30.10; Integrase_C; 1.
DR   Pfam; PF00552; Integrase; 1.
DR   SUPFAM; SSF50122; Integrase_C; 1.
DR   SUPFAM; SSF53098; RNaseH_fold; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; PARTIAL.
DR   PROSITE; PS50994; INTEGRASE; 1.
DR   PROSITE; PS51027; INTEGRASE_DBD; 1.
PE   1: Evidence at protein level;
KW   3D-structure; AIDS; DNA integration; DNA recombination; Endonuclease;
KW   Hydrolase; Nuclease.
FT   CHAIN        <1    148       Gag-Pol polyprotein.
FT                                /FTId=PRO_0000261289.
FT   CHAIN        <1    148       Integrase (By similarity).
FT                                /FTId=PRO_0000042448.
FT   DOMAIN       <1     64       Integrase catalytic.
FT   DNA_BIND     83    130       Integrase-type.
FT   NON_TER       1      1
FT   STRAND       82     88
FT   STRAND       93    115
FT   STRAND      117    121
FT   HELIX       122    124
FT   STRAND      125    129
SQ   SEQUENCE   148 AA;  16840 MW;  A0DD31618CF0FC0E CRC64;
     IPYNPQSQGV VESMNKELKK IIGQVRDQAE HLKTAVQMAV FIHNFKRKGG IGGYSAGERI
     IDIIATDIQT KELQKQITKI QNFRVYYRDS RDPIWKGPAK LLWKGEGAVV IQDNSDIKVV
     PRRKVKIIRD YGKQMAGDDC VASRQDED
//