ID POL_HV1Z6 STANDARD; PRT; 148 AA. AC P04586; DT 13-AUG-1987 (Rel. 05, Created) DT 13-AUG-1987 (Rel. 05, Last sequence update) DT 24-JAN-2006 (Rel. 49, Last annotation update) DE Gag-Pol polyprotein (Pr160Gag-Pol) [Contains: Integrase (IN)] DE (Fragment). GN Name=GAG; GN and GN Name=POL; OS Human immunodeficiency virus type 1 (isolate Zaire 6) (HIV-1). OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11708; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RX MEDLINE=87248097; PubMed=3036660; DOI=10.1016/0378-1119(87)90396-9; RA Srinivasan A., Anand R., York D., Ranganathan P., Feorino P., RA Schochetman G., Curran J., Kalyanaraman V.S., Luciw P.A., RA Sanchez-Pescador R.; RT "Molecular characterization of human immunodeficiency virus from RT Zaire: nucleotide sequence analysis identifies conserved and variable RT domains in the envelope gene."; RL Gene 52:71-82(1987). CC -!- FUNCTION: During replicative cycle of retroviruses, the reverse- CC transcribed viral DNA is integrated into the host chromosome by CC the viral integrase enzyme. RNase H activity is associated with CC the reverse transcriptase. CC -!- PTM: Specific enzymatic cleavages by the viral protease yield CC mature proteins. The polyprotein is cleaved during and after CC budding, this process is termed maturation (By similarity). CC -!- SIMILARITY: Belongs to the retroviruses Gag-Pol polyprotein CC family. CC -!- SIMILARITY: Contains 1 integrase catalytic domain. CC -!- SIMILARITY: Contains 1 integrase-type DNA-binding domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; K03458; AAA45376.1; -; Genomic_RNA. DR PIR; A26192; A26192. DR PDB; 1IHV; NMR; A/B=80-130. DR PDB; 1IHW; NMR; A/B=80-130. DR SMR; P04586; 5-130. DR HIV; K03458; POL$Z6. DR LinkHub; P04586; -. DR InterPro; IPR001037; Integrase_C. DR InterPro; IPR001969; Pept_Asp_AS. DR InterPro; IPR012337; RNaseH_fold. DR InterPro; IPR001584; Rve. DR Pfam; PF00552; Integrase; 1. DR PROSITE; PS00141; ASP_PROTEASE; PARTIAL. DR PROSITE; PS50994; INTEGRASE; 1. DR PROSITE; PS51027; INTEGRASE_DBD; 1. KW 3D-structure; AIDS; DNA integration; DNA recombination; Endonuclease; KW Hydrolase; Nuclease; Polyprotein. FT CHAIN <1 148 Integrase (By similarity). FT /FTId=PRO_0000042448. FT DOMAIN <1 64 Integrase catalytic. FT DNA_BIND 83 130 Integrase-type. FT NON_TER 1 1 FT STRAND 83 88 FT STRAND 95 104 FT STRAND 108 112 FT STRAND 117 121 FT HELIX 122 124 FT STRAND 125 129 SQ SEQUENCE 148 AA; 16840 MW; A0DD31618CF0FC0E CRC64; IPYNPQSQGV VESMNKELKK IIGQVRDQAE HLKTAVQMAV FIHNFKRKGG IGGYSAGERI IDIIATDIQT KELQKQITKI QNFRVYYRDS RDPIWKGPAK LLWKGEGAVV IQDNSDIKVV PRRKVKIIRD YGKQMAGDDC VASRQDED //