ID UTS2A_CYPCA Reviewed; 125 AA. AC P04560; DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1988, sequence version 1. DT 29-MAY-2024, entry version 73. DE RecName: Full=Prepro-urotensin II-alpha; DE Contains: DE RecName: Full=Urophysin alpha; DE Contains: DE RecName: Full=Urotensin II-alpha; DE Short=U-II-alpha; DE Short=UII-alpha; DE Flags: Precursor; OS Cyprinus carpio (Common carp). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Cyprininae; Cyprinus. OX NCBI_TaxID=7962; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=2427672; DOI=10.1523/jneurosci.06-09-02730.1986; RA Ohsako S., Ishida I., Ichikawa T., Deguchi T.; RT "Cloning and sequence analysis of cDNAs encoding precursors of urotensin RT II-alpha and -gamma."; RL J. Neurosci. 6:2730-2735(1986). RN [2] RP PROTEIN SEQUENCE OF 114-125. RA Munekata E., Ohtaki T., Ichikawa T., McMaster D., Lederis K.; RL (In) Rich D.H., Gross E. (eds.); RL Proceedings of the 7th American peptide symposium, pp.69-72, Pierce RL Chemical Co., Rockford Il. (1981). CC -!- FUNCTION: Urotensin is found in the teleost caudal neurosecretory CC system. It has a suggested role in osmoregulation and as a CC corticotropin-releasing factor. The non-hormonal portion of this CC precursor may be a urotensin binding protein, urophysin. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- SIMILARITY: Belongs to the urotensin-2 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M14084; AAA49215.1; -; mRNA. DR PIR; I50498; I50498. DR AlphaFoldDB; P04560; -. DR Proteomes; UP000694384; Unplaced. DR Proteomes; UP000694427; Unplaced. DR Proteomes; UP000694700; Unplaced. DR Proteomes; UP000694701; Unplaced. DR Proteomes; UP001155660; Genome assembly. DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter. DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW. DR GO; GO:0097746; P:blood vessel diameter maintenance; IEA:InterPro. DR GO; GO:0008217; P:regulation of blood pressure; IEA:InterPro. DR InterPro; IPR001483; Urotensin_II. DR PANTHER; PTHR14447; UROTENSIN 2; 1. DR PANTHER; PTHR14447:SF0; UROTENSIN-2; 1. DR Pfam; PF02083; Urotensin_II; 1. DR PROSITE; PS00984; UROTENSIN_II; 1. PE 1: Evidence at protein level; KW Cleavage on pair of basic residues; Direct protein sequencing; KW Disulfide bond; Hormone; Reference proteome; Secreted; Signal. FT SIGNAL 1..21 FT CHAIN 22..106 FT /note="Urophysin alpha" FT /evidence="ECO:0000255" FT /id="PRO_0000036335" FT PROPEP 109..111 FT /evidence="ECO:0000255" FT /id="PRO_0000036336" FT PEPTIDE 114..125 FT /note="Urotensin II-alpha" FT /id="PRO_0000036337" FT DISULFID 119..124 SQ SEQUENCE 125 AA; 13840 MW; 1FB6F86CA6B3A5AF CRC64; MMCNLLLSFS VLLLSCTHLV AHPVTDTADM TYSGPDSVEE AGGVSPDDFA VSDLNDLLQR AAVVEYSPLL SRENIKVPGQ IPKEALRELL LEKPYRLIPP SGLWGSRRQF RKRGGGADCF WKYCV //