ID UTS2A_CYPCA Reviewed; 125 AA. AC P04560; DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1988, sequence version 1. DT 21-AUG-2007, entry version 43. DE UII alpha precursor [Contains: Urophysin alpha; Urotensin II-alpha DE (UII-alpha) (U-II-alpha)]. OS Cyprinus carpio (Common carp). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Cyprinus. OX NCBI_TaxID=7962; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=86307061; PubMed=2427672; RA Ohsako S., Ishida I., Ichikawa T., Deguchi T.; RT "Cloning and sequence analysis of cDNAs encoding precursors of RT urotensin II-alpha and -gamma."; RL J. Neurosci. 6:2730-2735(1986). RN [2] RP PROTEIN SEQUENCE OF 114-125. RA Munekata E., Ohtaki T., Ichikawa T., McMaster D., Lederis K.; RL (In) Rich D.H., Gross E. (eds.); RL Proceedings of the 7th American peptide symposium, pp.69-72, Pierce RL Chemical Co., Rockford Il. (1981). CC -!- FUNCTION: Urotensin is found in the teleost caudal neurosecretory CC system. It has a suggested role in osmoregulation and as a CC corticotropin-releasing factor. The non-hormonal portion of this CC precursor may be a urotensin binding protein, urophysin. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- SIMILARITY: Belongs to the urotensin-2 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M14084; AAA49215.1; -; mRNA. DR PIR; I50498; I50498. DR InterPro; IPR001483; Urotensin_II. DR Pfam; PF02083; Urotensin_II; 1. DR PROSITE; PS00984; UROTENSIN_II; 1. PE 1: Evidence at protein level; KW Cleavage on pair of basic residues; Direct protein sequencing; KW Hormone; Secreted; Signal. FT SIGNAL 1 21 FT CHAIN 22 106 Urophysin alpha (Potential). FT /FTId=PRO_0000036335. FT PROPEP 109 111 Potential. FT /FTId=PRO_0000036336. FT PEPTIDE 114 125 Urotensin II-alpha. FT /FTId=PRO_0000036337. FT DISULFID 119 124 SQ SEQUENCE 125 AA; 13840 MW; 1FB6F86CA6B3A5AF CRC64; MMCNLLLSFS VLLLSCTHLV AHPVTDTADM TYSGPDSVEE AGGVSPDDFA VSDLNDLLQR AAVVEYSPLL SRENIKVPGQ IPKEALRELL LEKPYRLIPP SGLWGSRRQF RKRGGGADCF WKYCV //