ID UR2A$CYPCA STANDARD; PRT; 125 AA. AC P04560; DT 13-AUG-1987 (REL. 05, CREATED) DT 01-JAN-1988 (REL. 06, LAST SEQUENCE UPDATE) DT 01-MAY-1991 (REL. 18, LAST ANNOTATION UPDATE) DE UROTENSIN II, ALPHA PRECURSOR. OS CYPRINUS CARPIO (COMMON CARP). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; PISCES; GNATHOSTOMATA; OC OSTEICHTHYES. RN [1] RP SEQUENCE FROM N.A. RC MEDLINE=86307061; RA OHSAKO S., ISHIDA I., ICHIKAWA T., DEGUCHI T.; RL J. NEUROSCI. 6:2730-2735(1986). RN [2] RP UROTENSIN II, SEQUENCE OF 114-125. RA MUNEKATA E., OHTAKI T., ICHIKAWA T., MCMASTER D., LEDERIS K.; RL (IN) PROCEEDINGS OF THE 7TH AMERICAN PEPTIDE SYMPOSIUM, RICH D.H., RL GROSS E., EDS, PP.69-72, PIERCE CHEMICAL, ROCKFORD IL., (1981). CC -!- FUNCTION: UROTENSIN IS FOUND IN THE TELEOST CAUDAL NEUROSECRETORY CC SYSTEM. IT HAS A SUGGESTED ROLE IN OSMOREGULATION AND AS A CC CORTICOTROPIN-RELEASING FACTOR. THE NONHORMONAL PORTION OF THIS CC PRECURSOR MAY BE A UROTENSIN BINDING PROTEIN, UROPHYSIN. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M14084; CCUIIA. KW HORMONE; CLEAVAGE ON PAIR OF BASIC RESIDUES; SIGNAL. FT SIGNAL 1 21 FT CHAIN 22 106 UROPHYSIN (PUTATIVE). FT PEPTIDE 114 125 UROTENSIN II-ALPHA. FT DISULFID 119 124 SQ SEQUENCE 125 AA; 13840 MW; 79911 CN; MMCNLLLSFS VLLLSCTHLV AHPVTDTADM TYSGPDSVEE AGGVSPDDFA VSDLNDLLQR AAVVEYSPLL SRENIKVPGQ IPKEALRELL LEKPYRLIPP SGLWGSRRQF RKRGGGADCF WKYCV //