ID PRP1_HUMAN Reviewed; 392 AA. AC P04280; Q08805; Q15186; Q15187; Q15214; Q15215; Q16038; DT 20-MAR-1987, integrated into UniProtKB/Swiss-Prot. DT 13-SEP-2004, sequence version 2. DT 04-DEC-2007, entry version 66. DE Basic salivary proline-rich protein 1 precursor (Salivary proline-rich DE protein) [Contains: Basic peptide IB-6; Peptide P-H]. GN Name=PRB1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE M). RX MEDLINE=85289325; PubMed=2993301; RA Maeda N., Kim H.-S., Azen E.A., Smithies O.; RT "Differential RNA splicing and post-translational cleavages in the RT human salivary proline-rich protein gene system."; RL J. Biol. Chem. 260:11123-11130(1985). RN [2] RP NUCLEOTIDE SEQUENCE (ALLELE M). RX MEDLINE=93136586; PubMed=8422499; RA Kim H.-S., Lyons K.M., Saitoh E., Azen E.A., Smithies O., Maeda N.; RT "The structure and evolution of the human salivary proline-rich RT protein gene family."; RL Mamm. Genome 4:3-14(1993). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-251 AND 300-392 (ALLELE M). RX MEDLINE=84298176; PubMed=6089212; RA Azen E.A., Lyons K.M., McGonigal T., Barrett N.L., Clements L.S., RA Maeda N., Vanin E.F., Carlson D.M., Smithies O.; RT "Clones from the human gene complex coding for salivary proline-rich RT proteins."; RL Proc. Natl. Acad. Sci. U.S.A. 81:5561-5565(1984). RN [4] RP NUCLEOTIDE SEQUENCE OF 35-392 (ALLELES M AND S), AND POLYMORPHISM. RX MEDLINE=89121440; PubMed=2851479; RA Lyons K.M., Stein J.H., Smithies O.; RT "Length polymorphisms in human proline-rich protein genes generated by RT intragenic unequal crossing over."; RL Genetics 120:267-278(1988). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-392 (ALLELES L AND M). RX MEDLINE=93304421; PubMed=8317492; RA Azen E.A., Latreille P., Niece R.L.; RT "PRBI gene variants coding for length and null polymorphisms among RT human salivary Ps, PmF, PmS, and Pe proline-rich proteins (PRPs)."; RL Am. J. Hum. Genet. 53:264-278(1993). RN [6] RP PROTEIN SEQUENCE OF 275-392. RX MEDLINE=86243355; PubMed=3521730; DOI=10.1021/bi00357a013; RA Kauffman D., Hofmann T., Bennick A., Keller P.; RT "Basic proline-rich proteins from human parotid saliva: complete RT covalent structures of proteins IB-1 and IB-6."; RL Biochemistry 25:2387-2392(1986). RN [7] RP PROTEIN SEQUENCE OF 337-392. RX MEDLINE=84161824; PubMed=6671974; RA Saitoh E., Isemura S., Sanada K.; RT "Further fractionation of basic proline-rich peptides from human RT parotid saliva and complete amino acid sequence of basic proline-rich RT peptide P-H."; RL J. Biochem. 94:1991-1997(1983). CC -!- POLYMORPHISM: The number of repeats is polymorphic and varies CC among different alleles. The sequence shown is that of allele L CC (long). There are allele M (medium) and allele S (short) which CC contain 12 and 9 approximate tandem repeats repectively. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; K03204; AAA60185.1; -; mRNA. DR EMBL; K03205; AAA60186.1; -; mRNA. DR EMBL; K03206; AAA60187.1; -; mRNA. DR EMBL; S52986; AAA13341.2; -; Genomic_DNA. DR EMBL; M97220; AAB05816.1; -; Genomic_DNA. DR EMBL; K02575; AAA36502.1; -; Genomic_DNA. DR EMBL; K02576; AAA36503.1; -; Genomic_DNA. DR EMBL; X07516; CAA30394.2; -; Genomic_DNA. DR EMBL; X07517; CAA30395.2; -; Genomic_DNA. DR EMBL; S62928; AAB27288.2; -; Genomic_DNA. DR EMBL; S62941; AAB27289.1; -; Genomic_DNA. DR PIR; B40750; PIHUB6. DR PIR; C38355; C38355. DR PIR; D40750; D40750. DR UniGene; Hs.631726; -. DR Ensembl; ENSG00000121335; Homo sapiens. DR HGNC; HGNC:9337; PRB1. DR MIM; 180989; gene. DR PharmGKB; PA33699; -. DR ArrayExpress; P04280; -. DR CleanEx; HS_PRB1; -. DR GO; GO:0005576; C:extracellular region; NAS:UniProtKB. DR InterPro; IPR000637; AT_hook_DNA_bd. DR PRINTS; PR00929; ATHOOK. PE 1: Evidence at protein level; KW Direct protein sequencing; Polymorphism; Repeat; Signal. FT SIGNAL 1 16 FT CHAIN 17 392 Basic salivary proline-rich protein 1. FT /FTId=PRO_0000022129. FT CHAIN 275 392 Basic peptide IB-6. FT /FTId=PRO_0000022130. FT CHAIN 337 392 Peptide P-H. FT /FTId=PRO_0000022131. FT REPEAT 53 72 1. FT REPEAT 73 92 2. FT REPEAT 93 112 3. FT REPEAT 114 133 4. FT REPEAT 134 153 5. FT REPEAT 154 173 6. FT REPEAT 175 194 7. FT REPEAT 195 214 8. FT REPEAT 215 234 9. FT REPEAT 236 255 10. FT REPEAT 256 275 11. FT REPEAT 276 295 12. FT REPEAT 297 316 13. FT REPEAT 317 336 14. FT REPEAT 338 357 15. FT REGION 53 357 15 X 20 AA approximate tandem repeats of FT P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- FT [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- FT [PSR]. FT VARIANT 93 153 Missing (in allele M). FT /FTId=VAR_019693. FT VARIANT 106 319 Missing (in clone CP-5). FT /FTId=VAR_005562. FT VARIANT 106 299 Missing (in clone CP-4). FT /FTId=VAR_005561. FT VARIANT 134 255 Missing (in allele S). FT /FTId=VAR_019694. FT CONFLICT 18 33 NLNEDVSQEESPSLIA -> SCVGFYSVFLFSLCPL (in FT Ref. 3; AAA36502). FT CONFLICT 40 40 S -> P (in Ref. 3; AAA36502). FT CONFLICT 85 86 DK -> GKR (in Ref. 3; AAA36502). FT CONFLICT 128 128 K -> R (in Ref. 4; CAA30395). FT CONFLICT 216 217 PG -> R (in Ref. 3; AAA36502). FT CONFLICT 271 271 R -> Q (in Ref. 5; AAB27288). FT CONFLICT 274 274 Q -> R (in Ref. 4; CAA30395). FT CONFLICT 278 278 G -> R (in Ref. 4; CAA30395). FT CONFLICT 307 307 Q -> T (in Ref. 3; AAA36503). FT CONFLICT 326 326 A -> P (in Ref. 5; AAB27289). FT CONFLICT 330 330 S -> C (in Ref. 3; AAA36503). FT CONFLICT 337 337 A -> S (in Ref. 2, 4; CAA30395 and 7). FT CONFLICT 385 386 GR -> DK (in Ref. 3; AAA36503). SQ SEQUENCE 392 AA; 38546 MW; B3F4C5A01F335CB0 CRC64; MLLILLSVAL LALSSAQNLN EDVSQEESPS LIAGNPQGPS PQGGNKPQGP PPPPGKPQGP PPQGGNKPQG PPPPGKPQGP PPQGDKSRSP RSPPGKPQGP PPQGGNQPQG PPPPPGKPQG PPPQGGNKPQ GPPPPGKPQG PPPQGDKSQS PRSPPGKPQG PPPQGGNQPQ GPPPPPGKPQ GPPPQGGNKP QGPPPPGKPQ GPPPQGDKSQ SPRSPPGKPQ GPPPQGGNQP QGPPPPPGKP QGPPQQGGNR PQGPPPPGKP QGPPPQGDKS RSPQSPPGKP QGPPPQGGNQ PQGPPPPPGK PQGPPPQGGN KPQGPPPPGK PQGPPAQGGS KSQSARAPPG KPQGPPQQEG NNPQGPPPPA GGNPQQPQAP PAGQPQGPPR PPQGGRPSRP PQ //